AIMC Topic: Monocytes

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Blood-Based Immune Profiling Combined with Machine Learning Discriminates Psoriatic Arthritis from Psoriasis Patients.

International journal of molecular sciences Oct 12, 2021
Psoriasis (Pso) is a chronic inflammatory skin disease, and up to 30% of Pso patients develop psoriatic arthritis (PsA), which can lead to irreversible joint damage. Early detection of PsA in Pso patients is crucial for timely treatment but difficult...
Female Aged Adult Middle Aged ROC Curve Discriminant Analysis T-Lymphocytes, Regulatory Humans T-Lymphocyte Subsets Machine Learning B-Lymphocyte Subsets Monocytes Receptors, Chemokine Phenotype Psoriasis Diagnosis, Differential Arthritis, Psoriatic Area Under Curve
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Artificial Intelligence Predicts Severity of COVID-19 Based on Correlation of Exaggerated Monocyte Activation, Excessive Organ Damage and Hyperinflammatory Syndrome: A Prospective Clinical Study.

Frontiers in immunology Aug 27, 2021
BACKGROUND: Prediction of the severity of COVID-19 at its onset is important for providing adequate and timely management to reduce mortality.
Humans COVID-19 Macrophages Cytokines Prospective Studies Support Vector Machine HMGB1 Protein L-Lactate Dehydrogenase Alanine Transaminase Aspartate Aminotransferases Biomarkers Male Prognosis Middle Aged Female Severity of Illness Index SARS-CoV-2 Diagnosis, Computer-Assisted Monocytes
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Effects of galectin-1 on immunomodulatory properties of human monocyte-derived dendritic cells.

Growth factors (Chur, Switzerland) Jul 5, 2021
Our study aimed to evaluate the effects of Gal-1 in dose depending manner on maturation and immunomodulatory properties of monocyte-derived (Mo) DCs . The effects were analyzed by monitoring their phenotypic characteristics, cytokine profile, and the...
Monocytes Cell Differentiation Immunity Humans Galectin 1 Cells, Cultured Cytokines Dendritic Cells
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Using Unsupervised Machine Learning to Identify Age- and Sex-Independent Severity Subgroups Among Patients with COVID-19: Observational Longitudinal Study.

Journal of medical Internet research May 27, 2021
BACKGROUND: Early detection and intervention are the key factors for improving outcomes in patients with COVID-19.
Spain Unsupervised Machine Learning Triage Prognosis C-Reactive Protein Monocytes Emergency Service, Hospital Neutrophils Cell Count Humans Longitudinal Studies COVID-19 Cluster Analysis Lymphocytes Datasets as Topic L-Lactate Dehydrogenase Alanine Transaminase Aspartate Aminotransferases
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Machine Learning Approaches to Identify Factors Associated with Women's Vasomotor Symptoms Using General Hospital Data.

Journal of Korean medical science May 3, 2021
BACKGROUND: To analyze the factors associated with women's vasomotor symptoms (VMS) using machine learning.
Humans Machine Learning Thyrotropin Body Weight Menopause Sweating Women's Health Republic of Korea Female Middle Aged Decision Support Systems, Clinical Monocytes Vasomotor System Hot Flashes
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The Predictive Value of Monocytes in Immune Microenvironment and Prognosis of Glioma Patients Based on Machine Learning.

Frontiers in immunology Apr 16, 2021
Gliomas are primary malignant brain tumors. Monocytes have been proved to actively participate in tumor growth. Weighted gene co-expression network analysis was used to identify meaningful monocyte-related genes for clustering. Neural network and SVM...
Glioma Lymphocytes, Tumor-Infiltrating Databases, Genetic Molecular Sequence Annotation Leukocyte Count Genomics Computational Biology Immunotherapy Monocytes Treatment Outcome Biomarkers, Tumor Humans Gene Expression Profiling Machine Learning Transcriptome Prognosis ROC Curve Reproducibility of Results Tumor Microenvironment
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Single Cell RNA-Seq and Machine Learning Reveal Novel Subpopulations in Low-Grade Inflammatory Monocytes With Unique Regulatory Circuits.

Frontiers in immunology Feb 23, 2021
Subclinical doses of LPS (SD-LPS) are known to cause low-grade inflammatory activation of monocytes, which could lead to inflammatory diseases including atherosclerosis and metabolic syndrome. Sodium 4-phenylbutyrate is a potential therapeutic compou...
Mice, Inbred C57BL Quality Control Phenylbutyrates Gene Regulatory Networks Mice Monocytes Lipopolysaccharides Machine Learning Animals Male Single-Cell Analysis RNA-Seq
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Characterization of Antiphospholipid Syndrome Atherothrombotic Risk by Unsupervised Integrated Transcriptomic Analyses.

Arteriosclerosis, thrombosis, and vascular biology Dec 24, 2020
OBJECTIVE: Our aim was to characterize distinctive clinical antiphospholipid syndrome phenotypes and identify novel microRNA (miRNA)-mRNA-intracellular signaling regulatory networks in monocytes linked to cardiovascular disease. Approach and Results:...
Unsupervised Machine Learning Thrombosis Gene Expression Regulation Oligonucleotide Array Sequence Analysis Antiphospholipid Syndrome Risk Factors Adult Male Middle Aged Risk Assessment Gene Regulatory Networks Monocytes Humans Signal Transduction Cells, Cultured Cluster Analysis Female MicroRNAs Gene Expression Profiling Transcriptome Case-Control Studies Protein Interaction Maps
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A rapid white blood cell classification system based on multimode imaging technology.

Journal of biophotonics Sep 2, 2020
In order to simplify the complexity of white blood cell classification in existing point-of-care testing (POCT) testing equipment, a white blood cell classification detection system based on microfluidic and multimode imaging was constructed. Microfl...
Humans Neural Networks, Computer Technology Monocytes Leukocytes Lymphocytes
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Prediction Power on Cardiovascular Disease of Neuroimmune Guidance Cues Expression by Peripheral Blood Monocytes Determined by Machine-Learning Methods.

International journal of molecular sciences Sep 2, 2020
Atherosclerosis is the underlying pathology in a major part of cardiovascular disease, the leading cause of mortality in developed countries. The infiltration of monocytes into the vessel walls of large arteries is a key denominator of atherogenesis,...
Machine Learning Semaphorins Biomarkers Humans Male Cohort Studies Female Cardiovascular Diseases Adult Monocytes Middle Aged Ephrins Transcriptome Netrin-1 Case-Control Studies
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