Journal of chemical information and modeling
Feb 15, 2019
Blockade of the human ether-à-go-go-related gene (hERG) channel by small molecules induces the prolongation of the QT interval which leads to fatal cardiotoxicity and accounts for the withdrawal or severe restrictions on the use of many approved drug...
Multiparametric magnetic resonance imaging (mpMRI) has become increasingly important for the clinical assessment of prostate cancer (PCa), but its interpretation is generally variable due to its relatively subjective nature. Radiomics and classificat...
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation
Feb 6, 2019
BACKGROUND: We previously reported a microarray-based diagnostic system for heart transplant endomyocardial biopsies (EMBs), using either 3-archetype (3AA) or 4-archetype (4AA) unsupervised algorithms to estimate rejection. In the present study we ex...
Artificial neural networks are machine-learning algorithms designed to analyse data without a pre-existing hypothesis as to any associations that may exist. This technique has not previously been applied to the risk stratification of patients referre...
BACKGROUND: Identification of individuals at increased risk for suicide is an important public health priority, but the extent to which considering clinical phenomenology improves prediction of longer term outcomes remains understudied. Hospital disc...
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association
Jan 29, 2019
BACKGROUND & AIMS: Many patients with cirrhosis who undergo esophagogastroduodenoscopy (EGD) screening for esophageal varices (EVs) are found to have no or only small EVs. Endoscopic screening for EVs is therefore a potentially deferrable procedure t...
International journal of environmental research and public health
Jan 25, 2019
The objective of this paper is to predict the future driving risk of crash-involved drivers in Kunshan, China. A systematic machine learning framework is proposed to deal with three critical technical issues: 1. defining driving risk; 2. developing r...
PURPOSE OF THE REVIEW: Rheumatoid arthritis (RA) is a chronic, autoimmune disease which may result in a higher risk of cardiovascular (CV) events and stroke. Tissue characterization and risk stratification of patients with rheumatoid arthritis are a ...
This study presents the work in predicting crash risk on expressways with consideration of both the impact of safety critical events and traffic conditions. The traffic resilience theory is introduced to learn safety problems from the standpoint of 1...
International journal of molecular sciences
Jan 17, 2019
The risk of adverse drug reactions increases in a polypharmacology setting. High-throughput drug screening with transcriptomics applied to human cells has shown that drugs have effects on several molecular pathways, and these affected pathways may be...
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