AIMC Topic: Tissue Distribution
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Development of a highly sensitive and specific ELISA method for the determination of l-corydalmine in SD rats with monoclonal antibody.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences
Sep 14, 2017
l-Corydalmine (l-CDL) is a potent analgesic constituent of the traditional Chinese medicine, Rhizoma Corydalis. However, the pharmacokinetic process and tissue distribution of l-CDL in vivo are still unknown. Therefore, it is necessary to establish a...
ADMETNet: The knowledge base of pharmacokinetics and toxicology network.
Journal of genetics and genomics = Yi chuan xue bao
May 3, 2017
The Variability of Translocator Protein Signal in Brain and Blood of Genotyped Healthy Humans Using In Vivo I-CLINDE SPECT Imaging: A Test-Retest Study.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
Nov 10, 2016
I-CLINDE is a radiotracer developed for SPECT and targets the 18-kDa translocator protein (TSPO). TSPO is upregulated in glial cells and used as a measure of neuroinflammation in a variety of central nervous system diseases. The aim of this study was...
Aged, 80 and over
Adult
Receptors, GABA
Brain
Humans
Molecular Imaging
Sensitivity and Specificity
Middle Aged
Female
Biomarkers
Bridged Bicyclo Compounds, Heterocyclic
Male
Genotype
Reproducibility of Results
Tissue Distribution
Radiopharmaceuticals
Aged
Tomography, Emission-Computed, Single-Photon
Reference Values
Differentiation between treatment-related changes and progressive disease in patients with high grade brain tumors using support vector machine classification based on DCE MRI.
Journal of neuro-oncology
Jan 11, 2016
Differentiation between treatment-related changes and progressive disease (PD) remains a major clinical challenge in the follow-up of patients with high grade brain tumors. The aim of this study was to differentiate between treatment-related changes ...
Aged
Young Adult
Adult
Survival Rate
Humans
Prognosis
Female
Magnetic Resonance Imaging
Glioblastoma
Neoplasm Grading
Combined Modality Therapy
Disease Progression
Tumor Burden
Brain Neoplasms
Support Vector Machine
Image Interpretation, Computer-Assisted
Male
Longitudinal Studies
Tissue Distribution
Middle Aged
Contrast Media
Endogenous and exogenous factors influencing the concentrations of adiponectin in body fluids and tissues in the bovine.
Domestic animal endocrinology
Dec 13, 2015
Adiponectin, one of the messenger molecules secreted from adipose tissue that are collectively termed adipokines, has been demonstrated to play a central role in lipid and glucose metabolism in humans and laboratory rodents; it improves insulin sensi...
NEURAL NETWORK MODELLING OF CARDIAC DOSE CONVERSION COEFFICIENT FOR ARBITRARY X-RAY SPECTRA.
Radiation protection dosimetry
Oct 28, 2015
In this article, an approach to compute the dose conversion coefficients (DCCs) is described for the computational voxel phantom 'High-Definition Reference Korean-Man' (HDRK-Man) using artificial neural networks (ANN). For this purpose, the voxel pha...
Pharmacokinetics of tildipirosin in pig tonsils.
Journal of veterinary pharmacology and therapeutics
Aug 12, 2015
The penetration of antimicrobials in pig tonsils is hardly known. The objective of the study was to quantify the tildipirosin (TD) penetration in tonsils. Animals were randomly divided into six groups (control, T1, T2 (1), T2(5), T2(10), and T2(15)) ...
A machine learning multimodal profiling of Per- and Polyfluoroalkyls (PFAS) distribution across animal species organs via clustering and dimensionality reduction techniques.
Food research international (Ottawa, Ont.)
Jun 1, 2025
Per- and polyfluoroalkyl substances (PFAS) contamination in aquatic and terrestrial organisms poses significant environmental and health risks. This study quantified 15 PFAS compounds across various tissues (liver, kidney, gill, muscle, skin, lung, b...
Pharmacodynamics and Pharmacokinetics of Levobupivacaine Used for Epidural Anesthesia in Patients with Liver Dysfunction.
Cell biochemistry and biophysics
Dec 1, 2015
The objective of this study was to study the pharmacodynamics and pharmacokinetics of levobupivacaine used for epidural anesthesia in patients with liver dysfunction. Twenty patients aged 20-60, American Society of Anesthesiologists (ASA) graded I-II...
[Distribution of Formic Acid after Methanol Intoxication in Rats].
Fa yi xue za zhi
Dec 1, 2015
OBJECTIVE: To investigate concentration and distribution in blood and tissues of formic acid after methanol intoxication in rats.
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