Journal of cachexia, sarcopenia and muscle
Jun 1, 2025
BACKGROUND: Muscle strength is one of the key components in the diagnosis of sarcopenia. The aim of this study was to train a machine learning model to predict reference values and percentiles for handgrip strength and chair-stand test (CST), in a la...
OBJECTIVE: Evaluating leukoaraiosis (LA) on CT is challenging due to its low contrast and similarity to parenchymal gliosis. We developed and validated a deep learning algorithm for LA segmentation using CT-MRIFLAIR paired data from a multicenter Kor...
Deep learning frameworks utilizing convolutional neural networks (CNNs) have frequently been used for brain age prediction and have achieved outstanding performance. Nevertheless, deep learning remains a black box as it is hard to interpret which bra...
Alzheimer's & dementia : the journal of the Alzheimer's Association
Jun 1, 2025
INTRODUCTION: The study aimed to develop and validate the Emergency Department Dementia Algorithm (EDDA) to detect dementia among older adults (65+) and support clinical decision-making in the emergency department (ED).
PURPOSE: Age-related macular degeneration (AMD) remains the leading cause of blindness in developed countries. There are many different intravitreal anti-vascular endothelial growth factor (VEGF) drugs available for the treatment of neovascular AMD (...
International journal of geriatric psychiatry
Jun 1, 2025
OBJECTIVES: Late-life depression often overlaps with neurodegenerative diseases leading to diagnostic and treatment challenges for neuropsychiatrists. This study aimed to differentiate elderly treatment-resistant depression (TRD) comorbid with parkin...
Proteomic studies have been instrumental in identifying brain, cerebrospinal fluid and plasma proteins associated with Alzheimer's disease (AD). Here, we comprehensively examined 6,905 aptamers corresponding to 6,106 unique proteins in plasma in more...
Deutsche medizinische Wochenschrift (1946)
Jun 1, 2025
According to forecasts, 27 % of the German population will be aged 65 or over by 2050. Age-associated multimorbidity, functional impairment and need for care have a considerable impact on the healthcare system. A comprehensive geriatric assessment (C...
BACKGROUND: Early identification of individuals who progress from normal cognition (NC) to mild cognitive impairment (MCI) may help prevent cognitive decline. We aimed to build predictive models using radiomic features of the bilateral hippocampus in...
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