AIMC Topic: Antineoplastic Combined Chemotherapy Protocols

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PAK6-Associated Support Vector Machine Classifier: A New Way to Evaluate Response and Survival of Gastric Cancer Treated by 5-FU/Oxaliplatin Chemotherapy.

EBioMedicine Jul 5, 2017
Antineoplastic Combined Chemotherapy Protocols Oxaliplatin Support Vector Machine Fluorouracil Organoplatinum Compounds p21-Activated Kinases Humans Stomach Neoplasms Colorectal Neoplasms
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Prediction of synergistic anti-cancer drug combinations based on drug target network and drug induced gene expression profiles.

Artificial intelligence in medicine Jun 3, 2017
OBJECTIVE: Synergistic drug combinations are promising therapies for cancer treatment. However, effective prediction of synergistic drug combinations is quite challenging as mechanisms of drug synergism are still unclear. Various features such as dru...
Gene Regulatory Networks Computational Biology Gene Expression Regulation, Neoplastic Signal Transduction Antineoplastic Combined Chemotherapy Protocols Neoplasms Gene Expression Profiling Artificial Intelligence Transcriptome Databases, Genetic Computer Simulation Reproducibility of Results Pharmacogenetics Drug Synergism Humans Protein Interaction Maps
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Correlation of Serum Cystatin C with Glomerular Filtration Rate in Patients Receiving Platinum-Based Chemotherapy.

Analytical cellular pathology (Amsterdam) Dec 18, 2016
. Serum cystatin C seems to be an accurate marker of glomerular filtration rate (GFR) compared to serum creatinine. The aim of this work was to explore the possibility of using serum cystatin C instead of serum creatinine to early predict renal failu...
Prognosis Female Aged Adult Sensitivity and Specificity Humans Biomarkers Cystatin C Male Creatinine Carboplatin Middle Aged Cisplatin Renal Insufficiency Neoplasms Antineoplastic Combined Chemotherapy Protocols Glomerular Filtration Rate
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Computational prediction of multidisciplinary team decision-making for adjuvant breast cancer drug therapies: a machine learning approach.

BMC cancer Dec 1, 2016
BACKGROUND: Multidisciplinary team (MDT) meetings are used to optimise expert decision-making about treatment options, but such expertise is not digitally transferable between centres. To help standardise medical decision-making, we developed a machi...
Middle Aged Models, Theoretical Antineoplastic Combined Chemotherapy Protocols Combined Modality Therapy Female Supervised Machine Learning Aged Aged, 80 and over Humans Chemotherapy, Adjuvant Adult Machine Learning Patient Care Team Algorithms Computer Simulation Clinical Decision-Making Breast Neoplasms
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Efficacy according to blind independent central review: Post-hoc analyses from the phase III, randomized, multicenter, IPASS study of first-line gefitinib versus carboplatin/paclitaxel in Asian patients with EGFR mutation-positive advanced NSCLC.

Lung cancer (Amsterdam, Netherlands) Nov 30, 2016
OBJECTIVE: The Phase III, randomized, open-label IPASS study (NCT00322452) of first-line epidermal growth factor receptor tyrosine kinase inhibitor (EGFR TKI) gefitinib versus carboplatin/paclitaxel for Asian patients with advanced non-small-cell lun...
Carcinoma, Non-Small-Cell Lung Protein Kinase Inhibitors Carboplatin Humans Randomized Controlled Trials as Topic Paclitaxel Middle Aged Female Gefitinib Disease-Free Survival Antineoplastic Agents Neoplasm Staging Aged Quinazolines Smoking Lung Neoplasms Mutation Antineoplastic Combined Chemotherapy Protocols ErbB Receptors Aged, 80 and over Asian People Adenocarcinoma Male
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Machine learning-based classification of diffuse large B-cell lymphoma patients by eight gene expression profiles.

Cancer medicine Feb 11, 2016
Gene expression profiling (GEP) had divided the diffuse large B-cell lymphoma (DLBCL) into molecular subgroups: germinal center B-cell like (GCB), activated B-cell like (ABC), and unclassified (UC) subtype. However, this classification with prognosti...
Middle Aged Gene Expression Profiling ROC Curve Antineoplastic Combined Chemotherapy Protocols Treatment Outcome Female Aged Sensitivity and Specificity Lymphoma, Large B-Cell, Diffuse Male Prednisone Rituximab Vincristine Genes, Neoplasm Antibodies, Monoclonal, Murine-Derived Germinal Center Support Vector Machine Databases, Genetic Doxorubicin Survival Analysis Cyclophosphamide Humans Prognosis
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Pharmacokinetics and Safety of Elotuzumab Combined With Lenalidomide and Dexamethasone in Patients With Multiple Myeloma and Various Levels of Renal Impairment: Results of a Phase Ib Study.

Clinical lymphoma, myeloma & leukemia Dec 21, 2015
INTRODUCTION: The present study evaluated the pharmacokinetics and safety of elotuzumab, a humanized IgG1 monoclonal antibody against signaling lymphocyte activation molecule-F7, combined with lenalidomide and dexamethasone, in patients with multiple...
Antibodies, Monoclonal, Humanized Kidney Diseases Thalidomide Neoplasm Staging Dexamethasone Multiple Myeloma Lenalidomide Cytogenetic Analysis Retreatment Middle Aged Severity of Illness Index Humans Antineoplastic Combined Chemotherapy Protocols Treatment Outcome Kidney Function Tests Female Aged Aged, 80 and over Adult Male
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Postoperative photodynamic therapy as a new adjuvant treatment after robot-assisted salvage surgery of recurrent squamous cell carcinoma of the base of tongue.

World journal of surgical oncology Jul 16, 2015
BACKGROUND: For patients who remain with involved resection margins after transoral robot-assisted salvage surgery (TORS) for recurrent squamous cell carcinoma (SCC) at the base of tongue (BOT) following primary (chemo)radiotherapy, further adjuvant ...
Robotics Neoplasm Staging Neoplasm Recurrence, Local Tongue Neoplasms Photochemotherapy Salvage Therapy Postoperative Period Chemotherapy, Adjuvant Female Carcinoma, Squamous Cell Male Middle Aged Antineoplastic Combined Chemotherapy Protocols Humans Prognosis
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HemOnc.org: A Collaborative Online Knowledge Platform for Oncology Professionals.

Journal of oncology practice Mar 3, 2015
PURPOSE: Cancer care involves extensive knowledge about numerous chemotherapy drugs and chemotherapy regimens. This information is constantly evolving, and there has been no freely available, comprehensive, centralized repository of chemotherapy info...
Cooperative Behavior Databases, Pharmaceutical Drug Information Services Humans Medical Oncology Treatment Outcome Software Computer Graphics Access to Information Neoplasms Interdisciplinary Communication Knowledge Bases User-Computer Interface Antineoplastic Combined Chemotherapy Protocols
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A Machine Learning-Based Strategy Predicts Selective and Synergistic Drug Combinations for Relapsed Acute Myeloid Leukemia.

Cancer research Jul 15, 2025
UNLABELLED: Combination therapies are one potential approach to improve the outcomes of patients with relapsed/refractory (R/R) disease. However, comprehensive testing in scarce primary patient material is hampered by the many drug combination possib...
Humans Antineoplastic Combined Chemotherapy Protocols Machine Learning Neoplasm Recurrence, Local Precision Medicine Drug Synergism Female Drug Resistance, Neoplasm Leukemia, Myeloid, Acute Bridged Bicyclo Compounds, Heterocyclic Single-Cell Analysis
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