AIMC Topic: Antineoplastic Combined Chemotherapy Protocols

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Machine learning-based classification of diffuse large B-cell lymphoma patients by eight gene expression profiles.

Cancer medicine Feb 11, 2016
Gene expression profiling (GEP) had divided the diffuse large B-cell lymphoma (DLBCL) into molecular subgroups: germinal center B-cell like (GCB), activated B-cell like (ABC), and unclassified (UC) subtype. However, this classification with prognosti...
Aged Sensitivity and Specificity Lymphoma, Large B-Cell, Diffuse Male Middle Aged Vincristine Gene Expression Profiling ROC Curve Genes, Neoplasm Antineoplastic Combined Chemotherapy Protocols Doxorubicin Antibodies, Monoclonal, Murine-Derived Treatment Outcome Survival Analysis Support Vector Machine Germinal Center Cyclophosphamide Humans Databases, Genetic Prednisone Prognosis Rituximab Female
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Pharmacokinetics and Safety of Elotuzumab Combined With Lenalidomide and Dexamethasone in Patients With Multiple Myeloma and Various Levels of Renal Impairment: Results of a Phase Ib Study.

Clinical lymphoma, myeloma & leukemia Dec 21, 2015
INTRODUCTION: The present study evaluated the pharmacokinetics and safety of elotuzumab, a humanized IgG1 monoclonal antibody against signaling lymphocyte activation molecule-F7, combined with lenalidomide and dexamethasone, in patients with multiple...
Kidney Function Tests Dexamethasone Humans Male Antibodies, Monoclonal, Humanized Female Multiple Myeloma Middle Aged Kidney Diseases Aged Lenalidomide Severity of Illness Index Thalidomide Aged, 80 and over Cytogenetic Analysis Antineoplastic Combined Chemotherapy Protocols Neoplasm Staging Adult Retreatment Treatment Outcome
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Postoperative photodynamic therapy as a new adjuvant treatment after robot-assisted salvage surgery of recurrent squamous cell carcinoma of the base of tongue.

World journal of surgical oncology Jul 16, 2015
BACKGROUND: For patients who remain with involved resection margins after transoral robot-assisted salvage surgery (TORS) for recurrent squamous cell carcinoma (SCC) at the base of tongue (BOT) following primary (chemo)radiotherapy, further adjuvant ...
Postoperative Period Chemotherapy, Adjuvant Neoplasm Staging Neoplasm Recurrence, Local Tongue Neoplasms Photochemotherapy Salvage Therapy Female Humans Carcinoma, Squamous Cell Prognosis Male Middle Aged Antineoplastic Combined Chemotherapy Protocols Robotics
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HemOnc.org: A Collaborative Online Knowledge Platform for Oncology Professionals.

Journal of oncology practice Mar 3, 2015
PURPOSE: Cancer care involves extensive knowledge about numerous chemotherapy drugs and chemotherapy regimens. This information is constantly evolving, and there has been no freely available, comprehensive, centralized repository of chemotherapy info...
Access to Information Knowledge Bases Medical Oncology Computer Graphics Interdisciplinary Communication Software Neoplasms User-Computer Interface Antineoplastic Combined Chemotherapy Protocols Treatment Outcome Cooperative Behavior Databases, Pharmaceutical Drug Information Services Humans
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Machine learning prediction of pathological complete response to neoadjuvant chemotherapy with peritumoral breast tumor ultrasound radiomics: compare with intratumoral radiomics and clinicopathologic predictors.

Breast cancer research and treatment Jul 1, 2025
PURPOSE: Noninvasive, accurate and novel approaches to predict patients who will achieve pathological complete response (pCR) after neoadjuvant chemotherapy (NAC) could assist treatment strategies. The aim of this study was to explore the application...
Chemotherapy, Adjuvant ROC Curve Antineoplastic Combined Chemotherapy Protocols Treatment Outcome Neoadjuvant Therapy Ultrasonography, Mammary Humans Machine Learning Prognosis Female Aged Adult Breast Neoplasms Radiomics Middle Aged
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Predicting the risk of ibrutinib in combination with R-ICE in patients with relapsed or refractory DLBCL using explainable machine learning algorithms.

Clinical and experimental medicine May 26, 2025
Relapsed or refractory diffuse large B-cell lymphoma (DLBCL) poses significant therapeutic challenges due to heterogeneous patient outcomes. This study aimed to evaluate the efficacy of the ibrutinib plus R-ICE regimen and to leverage explainable mac...
Aged, 80 and over Adult Lymphoma, Large B-Cell, Diffuse Male Middle Aged Antineoplastic Combined Chemotherapy Protocols Machine Learning Prognosis Retrospective Studies Female Aged Neoplasm Recurrence, Local Piperidines Cyclophosphamide Rituximab Adenine Humans
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Prediction of prognosis of immune checkpoint inhibitors combined with anti-angiogenic agents for unresectable hepatocellular carcinoma by machine learning-based radiomics.

BMC cancer May 19, 2025
OBJECTIVES: This study aims to develop and validate a novel radiomics model utilizing magnetic resonance imaging (MRI) to predict progression-free survival (PFS) in patients with unresectable hepatocellular carcinoma (uHCC) who are receiving a combin...
Humans Machine Learning Prognosis Retrospective Studies Female Aged Magnetic Resonance Imaging Progression-Free Survival Carcinoma, Hepatocellular Adult Immune Checkpoint Inhibitors Radiomics Nomograms Male Angiogenesis Inhibitors Middle Aged Antineoplastic Combined Chemotherapy Protocols Liver Neoplasms
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Artificial intelligence generated 3D body composition predicts dose modifications in patients undergoing neoadjuvant chemotherapy for rectal cancer.

Journal of cancer research and clinical oncology May 16, 2025
PURPOSE: Chemotherapy administration is a balancing act between giving enough to achieve the desired tumour response while limiting adverse effects. Chemotherapy dosing is based on body surface area (BSA). Emerging evidence suggests body composition ...
Aged Adult Male Middle Aged Imaging, Three-Dimensional Antineoplastic Combined Chemotherapy Protocols Neoadjuvant Therapy Body Composition Rectal Neoplasms Body Surface Area Humans Artificial Intelligence Retrospective Studies Female
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Protein Profiles Predict Treatment Responses to the PI3K Inhibitor Umbralisib in Patients with Chronic Lymphocytic Leukemia.

Clinical cancer research : an official journal of the American Association for Cancer Research May 15, 2025
PURPOSE: The management of chronic lymphocytic leukemia (CLL) has significantly improved with targeted therapies. However, many patients experience a suboptimal response. To optimally select the best therapy, predictive biomarkers are necessary. In t...
Humans Pyrazines Female Phosphatidylinositol 3-Kinases Aged Protein Kinase Inhibitors Agammaglobulinaemia Tyrosine Kinase Leukemia, Lymphocytic, Chronic, B-Cell Aged, 80 and over Benzamides Male Biomarkers, Tumor Phosphoinositide-3 Kinase Inhibitors Middle Aged Antineoplastic Combined Chemotherapy Protocols Treatment Outcome
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Artificial intelligence can help individualize Wilms tumor treatment by predicting tumor response to preoperative chemotherapy.

Investigative and clinical urology Jan 1, 2025
PURPOSE: To create a computer-aided prediction (CAP) system to predict Wilms tumor (WT) responsiveness to preoperative chemotherapy (PC) using pre-therapy contrast-enhanced computed tomography (CECT).
Dactinomycin Kidney Neoplasms Nephrectomy Preoperative Care Vincristine Wilms Tumor Precision Medicine Retrospective Studies Tomography, X-Ray Computed Female Male Infant Adolescent Humans Child, Preschool Artificial Intelligence Child Antineoplastic Combined Chemotherapy Protocols Treatment Outcome
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