The aim of this study was to investigate the relationship between serum ultrasensitive C-reactive protein (hs-CRP) levels and stroke incidence and to assess its potential role in decision-making for thrombolytic therapy in stroke. Given that hs-CRP i...
Chronic obstructive pulmonary disease (COPD) and asthma are common and serious respiratory diseases worldwide. Their clinical overlap and lack of specificity in current biomarkers pose a great diagnostic challenge for early diagnosis. To address this...
The Journal of clinical endocrinology and metabolism
Oct 16, 2025
CONTEXT: Metabolic dysfunction-associated steatotic liver disease (MASLD) is an umbrella term for simple hepatic steatosis and the more severe metabolic dysfunction-associated steatohepatitis. The current reliance on liver biopsy for diagnosis and a ...
BACKGROUND: Major depressive disorder (MDD) is characterized by significant heterogeneity in treatment response, with inflammation hypothesized to play a role in its pathophysiology. Peripheral inflammatory biomarkers, such as the neutrophil-to-lymph...
Xiang-Guang et al. investigate the identification of novel biomarkers linked to M1 macrophage infiltration in inflammatory bowel diseases (IBD). Utilizing advanced bioinformatics and machine learning techniques, the researchers developed predictive m...
Vascular dementia (VaD), the second most common form of dementia, lacks reliable biomarkers for early diagnosis. Here, we integrated weighted gene co-expression network analysis (WGCNA) with machine learning to identify novel biomarkers and immune-me...
BACKGROUNDS: The etiology of depression involves chronic stress, a recognized determinant of onset and severity. This study adopts a translational approach, utilizing a mouse model and a clinical cohort to explore the relationship between chronic str...
Systemic lupus erythematosus (SLE), a multifaceted autoimmune disorder, has lupus nephritis (LN) as one of its grave complications and is strongly associated with dyslipidemia. This investigation sought to delineate renal-specific lipid metabolism-re...
The risk of acute respiratory distress syndrome (ARDS) combined with acute kidney injury (AKI) is high and the prognosis is poor. Therefore, there is an urgent need for efficient and accurate methods to improve clinical doctors' early diagnosis and p...
Diabetes/metabolism research and reviews
Sep 1, 2025
AIMS: We aimed to explore the gut microbial and serum metabolic disturbances associated with the course of type 1 diabetes mellitus (T1DM), and identify potential biomarkers for discriminating T1DM from normoglycemia individuals by machine learning.
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