AIMC Topic: Biomarkers
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Exploring potential diagnostic markers and therapeutic targets for type 2 diabetes mellitus with major depressive disorder through bioinformatics and in vivo experiments.
Scientific reports
May 15, 2025
Type 2 diabetes mellitus (T2DM) and Major depressive disorder (MDD) act as risk factors for each other, and the comorbidity of both significantly increases the all-cause mortality rate. Therefore, studying the diagnosis and treatment of diabetes with...
Circulating fibroblast growth factor 21 is associated with blood pressure in the Chinese population: a community-based study.
Annals of medicine
May 12, 2025
BACKGROUND: Our research team previously found that fibroblast growth factor (FGF) 21, a circulating hormone, was significantly associated with atherosclerosis in human and animal models. The relationship between FGF21 and blood pressure (BP) is rare...
Development of a chitosanase 3-like protein 1 assay kit and study of its application in patients with hepatocellular carcinoma.
BMC biotechnology
May 12, 2025
OBJECTIVE: The detection kit for plasma Chitinase-3-like Protein 1 was developed using the magnetic bead chemiluminescence method, in order to investigate the diagnostic value of DD, FDP, CHI3L1, AFP-L3 and PIVKA-II in hepatocellular carcinoma.
Investigation of serum neuroserpin levels in pregnant women diagnosed with pre-eclampsia: a prospective case-control study.
BMC pregnancy and childbirth
May 10, 2025
OBJECTIVE: Neuroserpin, a serine protease inhibitor, is recognized for its anti-inflammatory and neuroprotective properties. Given the central role of inflammation and neurological involvement in the pathophysiology of preeclampsia, this study aimed ...
Defining the biomarkers in anti-MRSA fractions of soil Streptomycetes by multivariate analysis.
Antonie van Leeuwenhoek
May 10, 2025
Methicillin-resistant Staphylococcus aureus (MRSA) is one of the most alarming antibiotic-resistant pathogens causing nosocomial and community-acquired infections. Actinomycetes, particularly Streptomycetes, have historically been a major source of n...
High procalcitonin level is related to blood stream infections, gram-negative pathogens, and ICU admission in infections of adult febrile cancer patients.
Journal of the Egyptian National Cancer Institute
May 10, 2025
BACKGROUND: Blood stream infection (BSI) represent a life-threatening condition. Thus, we aimed to investigate the role of procalcitonin (PCT) and C-reactive protein (CRP) tests in adult febrile patients with BSI and other clinical infections in hosp...
Reduced blood EPAC1 protein levels as a marker of severe coronary artery disease: the role of hypoxic foam cell-transformed smooth muscle cells.
Journal of translational medicine
May 9, 2025
BACKGROUND: Vascular smooth muscle cells loaded with cholesterol (foam-VSMCs) play a crucial role in the progression of human atherosclerosis. Exchange Protein Directly Activated by cAMP 1 (EPAC1) is a critical protein in the regulation of vascular t...
A correlational study of plasma galectin-3 as a potential predictive marker of postoperative delirium in patients with acute aortic dissection.
Scientific reports
May 8, 2025
This study aimed to demonstrate whether plasma galectin-3 could predict the development of postoperative delirium (POD) in patients with acute aortic dissection (AAD). Prospective, observational study. Cardiac surgery intensive care unit. Consecutive...
Combining lipidomics and machine learning to identify lipid biomarkers for nonsyndromic cleft lip with palate.
JCI insight
May 8, 2025
Nonsyndromic cleft lip with palate (nsCLP) is a common birth defect disease. Current diagnostic methods comprise fetal ultrasound images, which are mainly limited by fetal position and technician skills. We aimed to identify reliable maternal serum l...
Classification of Neuropsychiatric Disorders via Brain-Region-Selected Graph Convolutional Network.
IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society
May 5, 2025
For the classification of patients with neuropsychiatric disorders based on rs-fMRI data, this paper proposed a Brain-Region-Selected graph convolutional network (BRS-GCN). In order to effectively identify the most significant biomarkers associated w...
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