AIMC Topic: CD8-Positive T-Lymphocytes

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The prognostic value of immunoscore in the early-onset colorectal cancer.

BMC gastroenterology Jul 10, 2025
BACKGROUND: The purpose of this study was to explore the prognostic value of Immunoscore in patients with early-onset colorectal cancer.
Age of Onset Immunohistochemistry Proportional Hazards Models Kaplan-Meier Estimate Aged Adult Colorectal Neoplasms Male Middle Aged Adenocarcinoma CD8-Positive T-Lymphocytes Neoplasm Staging Neural Networks, Computer Prognosis Retrospective Studies Female Humans
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Metabolic alterations driven by LDHA in CD8 + T cells promote immune evasion and therapy resistance in NSCLC.

Scientific reports Jul 8, 2025
Non-small cell lung cancer (NSCLC) is a leading cause of cancer-related deaths worldwide. Despite advancements in treatment, prognosis for patients with advanced stages remains poor. Metabolic reprogramming in the tumor microenvironment, particularly...
Immune Evasion Tumor Escape Lactate Dehydrogenase 5 Tumor Microenvironment Lung Neoplasms Glycolysis Gene Expression Regulation, Neoplastic Carcinoma, Non-Small-Cell Lung CD8-Positive T-Lymphocytes Drug Resistance, Neoplasm L-Lactate Dehydrogenase Humans Prognosis
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Predicting SARS-CoV-2-specific CD4 and CD8 T-cell responses elicited by inactivated vaccines in healthy adults using machine learning models.

Clinical and experimental medicine Jul 8, 2025
The ongoing evolution of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants highlights the importance of monitoring immune responses to guide vaccination strategies. Although neutralizing antibodies (NAbs) have garnered increasing ...
Machine Learning COVID-19 Female SARS-CoV-2 Humans Immunity, Cellular COVID-19 Vaccines Antibodies, Viral CD8-Positive T-Lymphocytes Young Adult Adult Male Middle Aged CD4-Positive T-Lymphocytes Healthy Volunteers Vaccines, Inactivated
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The tumor microenvironment of non-small cell lung cancer impairs immune cell function in people with HIV.

The Journal of clinical investigation Jun 3, 2025
Lung cancer is the leading cause of cancer mortality among people with HIV (PWH), with increased incidence and poor outcomes. This study explored whether the tumor microenvironment (TME) of HIV-associated non-small cell lung cancer (NSCLC) limits tum...
Humans Female Tumor Microenvironment Male Lymphocytes, Tumor-Infiltrating CD8-Positive T-Lymphocytes Neoplasm Proteins CD4-Positive T-Lymphocytes Middle Aged HIV Infections Lung Neoplasms Carcinoma, Non-Small-Cell Lung
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Single-cell and bulk transcriptome analyses reveal elevated amino acid metabolism promoting tumor-directed immune evasion in colorectal cancer.

Frontiers in immunology May 22, 2025
INTRODUCTION: Colorectal cancer (CRC), the third most common cancer worldwide, often shows limited responsiveness to immunotherapy due to its predominantly immune-excluded phenotype. Despite increasing insights into the complex tumor microenvironment...
Programmed Cell Death 1 Receptor Tumor Escape Lymphocytes, Tumor-Infiltrating CD8-Positive T-Lymphocytes Colorectal Neoplasms Amino Acids Transcriptome Humans Tumor Microenvironment Cell Line, Tumor Prognosis Male Single-Cell Analysis Female Gene Expression Regulation, Neoplastic Gene Expression Profiling
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MIST: An interpretable and flexible deep learning framework for single-T cell transcriptome and receptor analysis.

Science advances Apr 4, 2025
Joint analysis of transcriptomic and T cell receptor (TCR) features at single-cell resolution provides a powerful approach for in-depth T cell immune function research. Here, we introduce a deep learning framework for single-T cell transcriptome and ...
Humans COVID-19 SARS-CoV-2 T-Lymphocytes Gene Expression Profiling Transcriptome Deep Learning Single-Cell Analysis Chemokine CXCL13 Lung Neoplasms Receptors, Antigen, T-Cell Immunotherapy CD8-Positive T-Lymphocytes
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Immune profile and routine laboratory indicator-based machine learning for prediction of lung cancer.

Computers in biology and medicine Mar 31, 2025
INTRODUCTION: Early diagnosis of lung cancer is still a challenge by using current diagnostic methods.
Male Middle Aged Lung Neoplasms CD8-Positive T-Lymphocytes Humans Female Machine Learning Aged Adult
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High density of TCF1+ stem-like tumor-infiltrating lymphocytes is associated with favorable disease-specific survival in NSCLC.

Frontiers in immunology Dec 19, 2024
INTRODUCTION: Tumor-infiltrating lymphocytes are both prognostic and predictive biomarkers for immunotherapy response. However, less is known about the survival benefits oftheir subpopulations.
Lung Neoplasms Aged CD8-Positive T-Lymphocytes Humans Carcinoma, Non-Small-Cell Lung Biomarkers, Tumor Prognosis Lymphocytes, Tumor-Infiltrating Male Female Hepatocyte Nuclear Factor 1-alpha Middle Aged
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Machine learning-enhanced immunopeptidomics applied to T-cell epitope discovery for COVID-19 vaccines.

Nature communications Nov 28, 2024
Next-generation T-cell-directed vaccines for COVID-19 focus on establishing lasting T-cell immunity against current and emerging SARS-CoV-2 variants. Precise identification of conserved T-cell epitopes is critical for designing effective vaccines. He...
Humans Machine Learning COVID-19 Proteomics SARS-CoV-2 CD8-Positive T-Lymphocytes Epitopes, T-Lymphocyte COVID-19 Vaccines Spike Glycoprotein, Coronavirus
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A commentary on 'Single-cell and bulk RNA-sequence identified fibroblasts signature and CD8 + T cell - fibroblast subtype predicting prognosis and immune therapeutic response of bladder cancer, based on machine-learning'.

International journal of surgery (London, England) Sep 1, 2024
CD8-Positive T-Lymphocytes Single-Cell Analysis Immunotherapy Urinary Bladder Neoplasms Fibroblasts Humans Machine Learning Prognosis
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