AIMC Topic: Cell Survival
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Effect of dacarbazine on CD44 in live melanoma cells as measured by atomic force microscopy-based nanoscopy.
International journal of nanomedicine
Dec 18, 2017
CD44 ligand-receptor interactions are known to be involved in regulating cell migration and tumor cell metastasis. High expression levels of CD44 correlate with a poor prognosis of melanoma patients. In order to understand not only the mechanistic ba...
Ginsenoside Rg1 protects human renal tubular epithelial cells from lipopolysaccharide-induced apoptosis and inflammation damage.
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas
Dec 11, 2017
Ginsenoside Rg1, one of the most notable active components of Panax ginseng, has been widely reported to exert anti-inflammatory actions. This study aimed to reveal whether ginsenoside Rg1 also exhibits beneficial roles against lipopolysaccharide (LP...
Cytokines
Reproducibility of Results
Enzyme-Linked Immunosorbent Assay
Apoptosis
Lipopolysaccharides
Humans
Proto-Oncogene Proteins c-akt
Analysis of Variance
Kidney Tubules
Cell Migration Assays
Protective Agents
Cell Line
Blotting, Western
Reactive Oxygen Species
Anti-Inflammatory Agents
Epithelial Cells
Ginsenosides
Phosphatidylinositol 3-Kinases
Cell Survival
Nephritis
Oleanolic acid protects against pathogenesis of atherosclerosis, possibly via FXR-mediated angiotensin (Ang)-(1-7) upregulation.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Dec 8, 2017
Atherosclerosis, the leading cause of cardiovascular diseases in the world, is a chronic inflammatory disorder characterized by the dysfunction of arteries. Oleanolic acid (OA) is a bioactive nature product which exists in various plants and herbs. P...
Preliminary investigation on cytotoxicity of fluorinated polymer nanoparticles.
Journal of environmental sciences (China)
Nov 7, 2017
As well-known persistent organic pollutants (POPs), organofluorine pollutants such as perfluorooctane sulfonate (PFOS) have been proven to be bioaccumulated and harmful to health. However, toxicological assessment of organofluorinated nanoparticles, ...
Lycopene-rich extract from red guava (Psidium guajava L.) displays cytotoxic effect against human breast adenocarcinoma cell line MCF-7 via an apoptotic-like pathway.
Food research international (Ottawa, Ont.)
Oct 27, 2017
This study investigated a lycopene-rich extract from red guava (LEG) for its chemical composition using spectrophotometry, mass spectrometry, attenuated total reflectance-fourier transform infrared spectroscopy (ATR-FTIR), and computational studies. ...
Using machine learning algorithms to identify genes essential for cell survival.
BMC bioinformatics
Oct 3, 2017
BACKGROUND: With the explosion of data comes a proportional opportunity to identify novel knowledge with the potential for application in targeted therapies. In spite of this huge amounts of data, the solutions to treating complex disease is elusive....
Kinase inhibitor screening using artificial neural networks and engineered cardiac biowires.
Scientific reports
Sep 18, 2017
Kinase inhibitors are often used as cancer targeting agents for their ability to prevent the activation of cell growth and proliferation signals. Cardiotoxic effects have been identified for some marketed kinase inhibitors that were not detected duri...
Exploration of Wedelia chinensis leaf-assisted silver nanoparticles for antioxidant, antibacterial and in vitro cytotoxic applications.
Journal of food and drug analysis
Aug 31, 2017
Green synthetic route of silver nanoparticles (AgNPs) has already been proved to be an advantageous over other physico-chemical approaches due to its simplicity, cost effectiveness, ecofriendly and nontoxicity. In this finding, aqueous Wedelia chinen...
Epithelial-mesenchymal transition effect of fine particulate matter from the Yangtze River Delta region in China on human bronchial epithelial cells.
Journal of environmental sciences (China)
May 9, 2017
Epidemiological studies have demonstrated that fine particulate matter (PM) exposure causes airway inflammation, which may lead to lung cancer. The activation of epithelial-mesenchymal transition (EMT) is assumed to be a crucial step in lung tumor me...
Protective effect of Nelumbo nucifera extracts on beta amyloid protein induced apoptosis in PC12 cells, in vitro model of Alzheimer's disease.
Journal of food and drug analysis
Mar 17, 2017
Alzheimer's disease (AD) is the most common cause of dementia in the elderly. β-Amyloid (Aβ) has been proposed to play a role in the pathogenesis of AD. Deposits of insoluble Aβ are found in the brains of patients with AD and are one of the pathologi...
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