AIMC Topic: Diabetes Mellitus, Type 2

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Predictors of in-hospital mortality following major lower extremity amputations in type 2 diabetic patients using artificial neural networks.

BMC medical research methodology Nov 22, 2016
BACKGROUND: Outcome prediction is important in the clinical decision-making process. Artificial neural networks (ANN) have been used to predict the risk of post-operative events, including survival, and are increasingly being used in complex medical ...
Neural Networks, Computer Prognosis Retrospective Studies Female Aged Aged, 80 and over Humans Lower Extremity Male Patient Discharge Middle Aged Outcome Assessment, Health Care Prevalence Multivariate Analysis Comorbidity Spain Hospital Mortality Amputation, Surgical Diabetes Mellitus, Type 2
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Patient-level meta-analysis of efficacy and hypoglycaemia in people with type 2 diabetes initiating insulin glargine 100U/mL or neutral protamine Hagedorn insulin analysed according to concomitant oral antidiabetes therapy.

Diabetes research and clinical practice Nov 9, 2016
AIMS: Evaluate efficacy and hypoglycaemia according to concomitant oral antidiabetes drug (OAD) in people with type 2 diabetes initiating insulin glargine 100U/mL (Gla-100) or neutral protamine Hagedorn (NPH) insulin once daily.
Clinical Trials, Phase IV as Topic Insulin, Isophane Sulfonylurea Compounds Insulin Glargine Hypoglycemia Administration, Oral Drug Therapy, Combination Weight Gain Clinical Trials, Phase III as Topic Diabetes Mellitus, Type 2 Humans Hypoglycemic Agents Female Treatment Outcome Male Randomized Controlled Trials as Topic Incidence Glycated Hemoglobin
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Prediction of Incident Diabetes in the Jackson Heart Study Using High-Dimensional Machine Learning.

PloS one Oct 11, 2016
Statistical models to predict incident diabetes are often based on limited variables. Here we pursued two main goals: 1) investigate the relative performance of a machine learning method such as Random Forests (RF) for detecting incident diabetes in ...
Humans Machine Learning Biomarkers Female Aged Models, Theoretical Follow-Up Studies C-Reactive Protein Glycated Hemoglobin Leptin Waist Circumference Adult Male Middle Aged Blood Glucose Incidence Diabetes Mellitus, Type 2 Demography Cholesterol, HDL Anthropometry Adiponectin Triglycerides Black or African American
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A machine learning-based framework to identify type 2 diabetes through electronic health records.

International journal of medical informatics Oct 1, 2016
OBJECTIVE: To discover diverse genotype-phenotype associations affiliated with Type 2 Diabetes Mellitus (T2DM) via genome-wide association study (GWAS) and phenome-wide association study (PheWAS), more cases (T2DM subjects) and controls (subjects wit...
Diabetes Mellitus, Type 2 Logistic Models Support Vector Machine Bayes Theorem Humans Machine Learning Algorithms Electronic Health Records Pilot Projects Genome-Wide Association Study
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Temporal changes in plasma markers of oxidative stress following laparoscopic sleeve gastrectomy in subjects with impaired glucose regulation.

Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery Aug 31, 2016
BACKGROUND: Laparoscopic sleeve gastrectomy (LSG) is an effective treatment for obesity and associated metabolic complications. Obesity and type 2 diabetes are associated with increased oxidative stress. Previous studies have examined changes in plas...
Male Middle Aged Blood Glucose Oxidative Stress Diabetes Mellitus, Type 2 Antioxidants Prospective Studies Humans Biomarkers Glucose Intolerance Female Postoperative Care Thiobarbiturates Young Adult Laparoscopy Adult Gastrectomy Obesity, Morbid Glucose Tolerance Test Homeostasis
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Diet-induced weight loss and markers of endothelial dysfunction and inflammation in treated patients with type 2 diabetes.

Clinical nutrition ESPEN Jul 25, 2016
BACKGROUND & AIMS: Overweight and obesity increase cardiovascular mortality in patients with type 2 diabetes (T2D). In a recent trial, however, diet-induced weight loss did not reduce the cardiovascular risk of patients with T2D, possibly due to the ...
Insulin Young Adult Humans Obesity Diabetes Mellitus, Type 2 Adult Biomarkers Vascular Cell Adhesion Molecule-1 Inflammation Male Female Cholesterol, LDL Overweight Cardiovascular Diseases Risk Factors Endothelium, Vascular Body Mass Index Middle Aged Aged Diet, Reducing Adolescent
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Learning statistical models of phenotypes using noisy labeled training data.

Journal of the American Medical Informatics Association : JAMIA May 12, 2016
OBJECTIVE: Traditionally, patient groups with a phenotype are selected through rule-based definitions whose creation and validation are time-consuming. Machine learning approaches to electronic phenotyping are limited by the paucity of labeled traini...
Diabetes Mellitus, Type 2 Logistic Models Humans Models, Statistical Machine Learning Myocardial Infarction Algorithms Vocabulary, Controlled Phenotype Medical Informatics Computing Electronic Health Records
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Comparison of Clinical Trajectories before Initiation of Renal Replacement Therapy between Diabetic Nephropathy and Nephrosclerosis on the KDIGO Guidelines Heat Map.

Journal of diabetes research Dec 29, 2015
This study investigated differences between the clinical trajectories of diabetic nephropathy and nephrosclerosis using the Kidney Disease: Improving Global Outcomes (KDIGO) heat map and the clinical characteristics between the two diseases at RRT in...
Humans Retrospective Studies Renal Replacement Therapy Female Aged Adult Male Middle Aged Serum Albumin Kidney Function Tests Nephrosclerosis Albuminuria Disease Progression Biopsy Diabetes Mellitus, Type 2 Creatinine Diabetic Nephropathies Nephrology Kidney Practice Guidelines as Topic Glomerular Filtration Rate
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Resting Heart Rate Does Not Predict Cardiovascular and Renal Outcomes in Type 2 Diabetic Patients.

Journal of diabetes research Dec 28, 2015
Elevated resting heart rate (RHR) has been associated with increased risk of mortality and cardiovascular events. Limited data are available so far in type 2 diabetic (T2DM) subjects with no study focusing on progressive renal decline specifically. A...
Heart Rate Humans Czech Republic Prospective Studies Kaplan-Meier Estimate Diabetes Mellitus, Type 2 Female Diabetic Nephropathies Risk Factors Kidney Aged Glomerular Filtration Rate Male Predictive Value of Tests Cardiovascular Diseases Middle Aged Disease Progression Time Factors
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Can metformin change the prognosis of pancreatic cancer? Retrospective study for pancreatic cancer patients with pre-existing diabetes mellitus type 2.

Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver Dec 21, 2015
BACKGROUNDS: The effect of metformin on survival in patients with pancreatic cancer is controversial.
Kaplan-Meier Estimate Neoplasm Staging CA-19-9 Antigen Metformin Proportional Hazards Models Multivariate Analysis Republic of Korea Female Aged Aged, 80 and over Adult Survival Rate Male Middle Aged Diabetes Mellitus, Type 2 Hypoglycemic Agents Pancreatic Neoplasms Humans Prognosis Retrospective Studies
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