AIMC Topic: Disease Models, Animal

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PsyGeNET: a knowledge platform on psychiatric disorders and their genes.

Bioinformatics (Oxford, England)
UNLABELLED: PsyGeNET (Psychiatric disorders and Genes association NETwork) is a knowledge platform for the exploratory analysis of psychiatric diseases and their associated genes. PsyGeNET is composed of a database and a web interface supporting data...

A novel device for studying weight supported, quadrupedal overground locomotion in spinal cord injured rats.

Journal of neuroscience methods
BACKGROUND: Providing weight support facilitates locomotion in spinal cord injured animals. To control weight support, robotic systems have been developed for treadmill stepping and more recently for overground walking.

Using trend templates in a neonatal seizure algorithm improves detection of short seizures in a foetal ovine model.

Physiological measurement
Seizures below one minute in duration are difficult to assess correctly using seizure detection algorithms. We aimed to improve neonatal detection algorithm performance for short seizures through the use of trend templates for seizure onset and end. ...

Robotic natural orifice transluminal endoscopic surgery (R-NOTES): literature review and prototype system.

Minimally invasive therapy & allied technologies : MITAT : official journal of the Society for Minimally Invasive Therapy
In minimally invasive surgery methods such as laparoscopic surgery, surgical instruments are introduced through small incisions to minimize patient trauma and recovery times. To reduce the number of incisions, new techniques such as natural orifice t...

Key RNA-binding proteins in renal fibrosis: a comprehensive bioinformatics and machine learning framework for diagnostic and therapeutic insights.

Renal failure
BACKGROUND: Renal fibrosis is a critical factor in chronic kidney disease progression, with limited diagnostic and therapeutic options. Emerging evidence suggests RNA-binding proteins (RBPs) are pivotal in regulating cellular mechanisms underlying fi...

Innovative application of confocal Raman spectroscopy and Machine learning in cardiovascular diseases identification.

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy
Myocardial hypertrophy and heart failure are leading causes of mortality in cardiovascular diseases, yet current diagnostic techniques lack the resolution to monitor molecular changes effectively. In this study, we employed confocal Raman spectroscop...

Metasurface-enhanced terahertz imaging for glioblastoma in orthotopic xenograft mouse model combined with neural network decision making.

Biosensors & bioelectronics
Terahertz (THz) optical sensing and imaging offer significant potential in a range of biological and medical applications owing to their low-energy, non-ionizing nature, and ultra-broadband spectral information, which includes numerous molecular fing...

MIA and CD163 as promising diagnostic biomarkers in vascular dementia: A multi-method study combining WGCNA, machine learning with validation in animal models and clinical samples.

International immunopharmacology
Vascular dementia (VaD), the second most common form of dementia, lacks reliable biomarkers for early diagnosis. Here, we integrated weighted gene co-expression network analysis (WGCNA) with machine learning to identify novel biomarkers and immune-me...

Assessment of Myocardial Injury Size Metrics Using Carotid Pressure Waveform: Proof-of-Concept in Coronary Occlusion/Reperfusion Rat Model.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Myocardial infarction (MI) is a leading cause of death worldwide and the most common precursor to heart failure, even after initial treatment. Precise evaluation of myocardial injury is crucial for assessing interventions and improving outcomes. Exte...

Macrophage histone lactylation in atherosclerosis progression: mechanisms, predictive models, and therapeutic potential of Ruan Jian Qing Mai formula.

Life sciences
AIMS: This study investigates the role of macrophage histone lactylation-a protein modification-in atherosclerosis progression, particularly in peripheral artery disease (PAD), and evaluates the therapeutic potential of the herbal formula Ruan Jian Q...