AIMC Topic: Ferroptosis

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Identification of ferroptosis-related genes associated with diffuse large B-cell lymphoma via bioinformatics and machine learning approaches.

International journal of biological macromolecules Oct 31, 2024
Ferroptosis has emerged as a critical mechanism in the development and progression of various tumors, particularly diffuse large B-cell lymphoma (DLBCL). However, the thorough characterization of ferroptosis-related genes in DLBCL remains inadequatel...
Biomarkers, Tumor Lymphoma, Large B-Cell, Diffuse Gene Expression Profiling Gene Regulatory Networks Humans Machine Learning Tumor Microenvironment Computational Biology Gene Expression Regulation, Neoplastic Databases, Genetic Ferroptosis
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Salidroside sensitizes Triple-negative breast cancer to ferroptosis by SCD1-mediated lipogenesis and NCOA4-mediated ferritinophagy.

Journal of advanced research Sep 29, 2024
INTRODUCTION: Triple-negative breast cancer (TNBC) is the primary cause of breast cancer-induced death in women. Literature has confirmed the benefits of Salidroside (Sal) in treating TNBC. However, the study about potential therapeutic targets and m...
Triple Negative Breast Neoplasms Signal Transduction Mice, Nude Ferroptosis Animals Xenograft Model Antitumor Assays Cell Line, Tumor Phenols Humans Stearoyl-CoA Desaturase Mice Autophagy Lipogenesis Female Glucosides Nuclear Receptor Coactivators Ferritins
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Screening COPD-Related Biomarkers and Traditional Chinese Medicine Prediction Based on Bioinformatics and Machine Learning.

International journal of chronic obstructive pulmonary disease Sep 24, 2024
PURPOSE: To employ bioinformatics and machine learning to predict the characteristics of immune cells and genes associated with the inflammatory response and ferroptosis in chronic obstructive pulmonary disease (COPD) patients and to aid in the devel...
Pulmonary Disease, Chronic Obstructive Lung Genetic Markers Molecular Docking Simulation Gene Expression Profiling Predictive Value of Tests Machine Learning Mendelian Randomization Analysis Phenotype Drugs, Chinese Herbal Databases, Genetic Biomarkers Humans Medicine, Chinese Traditional Transcriptome Ferroptosis MicroRNAs Gene Regulatory Networks Genetic Predisposition to Disease Computational Biology
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Developing a machine learning-based prognosis and immunotherapeutic response signature in colorectal cancer: insights from ferroptosis, fatty acid dynamics, and the tumor microenvironment.

Frontiers in immunology Jul 15, 2024
INSTRUCTION: Colorectal cancer (CRC) poses a challenge to public health and is characterized by a high incidence rate. This study explored the relationship between ferroptosis and fatty acid metabolism in the tumor microenvironment (TME) of patients ...
Female Colorectal Neoplasms Tumor Microenvironment Biomarkers, Tumor Male Gene Expression Profiling Transcriptome Immunotherapy Gene Expression Regulation, Neoplastic Humans Ferroptosis Machine Learning Fatty Acids Prognosis
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Investigation of ferroptosis-associated molecular subtypes and immunological characteristics in lupus nephritis based on artificial neural network learning.

Arthritis research & therapy Jul 3, 2024
BACKGROUND: Lupus nephritis (LN) is a severe complication of systemic lupus erythematosus (SLE) with poor treatment outcomes. The role and underlying mechanisms of ferroptosis in LN remain largely unknown. We aimed to explore ferroptosis-related mole...
Machine Learning Prognosis Female Adult Male Middle Aged Ferroptosis Humans Lupus Nephritis Neural Networks, Computer
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Machine learning-based identification and immune characterization of ferroptosis-related molecular clusters in osteoarthritis and validation.

Aging May 29, 2024
Osteoarthritis (OA), a degenerative joint disease, involves synovial inflammation, subchondral bone erosion, and cartilage degeneration. Ferroptosis, a regulated non-apoptotic programmed cell death, is associated with various diseases. This study inv...
Humans Ferroptosis Machine Learning Osteoarthritis Gene Expression Profiling Databases, Genetic Cluster Analysis
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Deciphering Ferroptosis: From Molecular Pathways to Machine Learning-Guided Therapeutic Innovation.

Molecular biotechnology Apr 13, 2024
Ferroptosis is a unique form of cell death reliant on iron and lipid peroxidation. It disrupts redox balance, causing cell death by damaging the plasma membrane, with inducers acting through enzymatic pathways or transport systems. In cancer treatmen...
Neoplasms Signal Transduction Ferroptosis Humans Metabolic Networks and Pathways Machine Learning Iron Biomarkers Lipid Peroxidation Animals
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Mechanism of cytotoxicity induced by the cigarette smoke extract (CSE) of heated tobacco products in vascular smooth muscle cells: A comparative study of the cytotoxic effects of CSE and the ferroptosis inducer, erastin.

Journal of pharmacological sciences Dec 27, 2023
Heated tobacco products (HTPs) are marketed worldwide as less harmful alternatives to combustible cigarettes; however, their cytotoxic mechanisms in vascular smooth muscle cells are poorly understood. Ferroptosis is defined as iron-dependent cell dea...
Piperazines Antineoplastic Agents Cigarette Smoking Ferroptosis Muscle, Smooth, Vascular Iron Tobacco Products
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Clinical and Biological Significances of a Ferroptosis-Related Gene Signature in Lung Cancer Based on Deep Learning.

Computational and mathematical methods in medicine Aug 25, 2022
Acyl-CoA synthetase long-chain family member 4 (ACSL4) has been linked to the occurrence of tumors and is implicated in the ferroptosis process. Deep learning has been applied to many areas in health care, including imaging diagnosis, digital patholo...
Humans Deep Learning Lung Neoplasms Carcinoma, Non-Small-Cell Lung Ferroptosis Coenzyme A Ligases
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CDKN1A and EGR1 are key genes for endoplasmic reticulum stress-induced ferroptosis in MASH.

Free radical biology & medicine Aug 16, 2025
Metabolic dysfunction-associated steatohepatitis (MASH) is a complex liver disease whose pathogenesis involving endoplasmic reticulum (ER) stress and ferroptosis. However, key regulatory genes remain poorly understood, hindering the development of ef...
Humans Animals Male Mice Cyclin-Dependent Kinase Inhibitor p21 Fatty Liver Ferroptosis Mice, Inbred C57BL Disease Models, Animal Non-alcoholic Fatty Liver Disease Phenylenediamines Liver Hep G2 Cells Gene Expression Regulation Diet, High-Fat Early Growth Response Protein 1 Endoplasmic Reticulum Stress
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