AIMC Topic: Ferroptosis
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Machine learning-based identification and immune characterization of ferroptosis-related molecular clusters in osteoarthritis and validation.
Aging
May 29, 2024
Osteoarthritis (OA), a degenerative joint disease, involves synovial inflammation, subchondral bone erosion, and cartilage degeneration. Ferroptosis, a regulated non-apoptotic programmed cell death, is associated with various diseases. This study inv...
Deciphering Ferroptosis: From Molecular Pathways to Machine Learning-Guided Therapeutic Innovation.
Molecular biotechnology
Apr 13, 2024
Ferroptosis is a unique form of cell death reliant on iron and lipid peroxidation. It disrupts redox balance, causing cell death by damaging the plasma membrane, with inducers acting through enzymatic pathways or transport systems. In cancer treatmen...
Mechanism of cytotoxicity induced by the cigarette smoke extract (CSE) of heated tobacco products in vascular smooth muscle cells: A comparative study of the cytotoxic effects of CSE and the ferroptosis inducer, erastin.
Journal of pharmacological sciences
Dec 27, 2023
Heated tobacco products (HTPs) are marketed worldwide as less harmful alternatives to combustible cigarettes; however, their cytotoxic mechanisms in vascular smooth muscle cells are poorly understood. Ferroptosis is defined as iron-dependent cell dea...
Clinical and Biological Significances of a Ferroptosis-Related Gene Signature in Lung Cancer Based on Deep Learning.
Computational and mathematical methods in medicine
Aug 25, 2022
Acyl-CoA synthetase long-chain family member 4 (ACSL4) has been linked to the occurrence of tumors and is implicated in the ferroptosis process. Deep learning has been applied to many areas in health care, including imaging diagnosis, digital patholo...
Deep transfer learning approach for automated cell death classification reveals novel ferroptosis-inducing agents in subsets of B-ALL.
Cell death & disease
May 18, 2025
Ferroptosis is a recently described type of regulated necrotic cell death whose induction has anti-cancer therapeutic potential, especially in hematological malignancies. However, efforts to uncover novel ferroptosis-inducing therapeutics have been l...
Integrating Bulk and Single-Cell Transcriptomics with Machine Learning Reveals a Heme Metabolism-Based Panel for Lung Adenocarcinoma Chemotherapy Resistance.
International journal of molecular sciences
May 14, 2025
Lung adenocarcinoma (LUAD) is a leading cause of cancer-related mortality, with heme metabolism playing a critical role in tumor progression and treatment resistance. This study investigates the clinical implications of heme metabolism in LUAD, focus...
Single-Cell Analysis
Lung Neoplasms
Gene Expression Regulation, Neoplastic
Gene Expression Profiling
Transcriptome
Cell Line, Tumor
Drug Resistance, Neoplasm
Ferroptosis
Humans
Adenocarcinoma of Lung
Multidrug Resistance-Associated Proteins
Cisplatin
Machine Learning
Multidrug Resistance-Associated Protein 2
Prognosis
Heme
Female
Antineoplastic Agents
Identification of Ferroptosis-Related Gene in Age-Related Macular Degeneration Using Machine Learning.
Immunity, inflammation and disease
Dec 1, 2024
BACKGROUND: Age-related macular degeneration (AMD) is a major cause of irreversible visual impairment, with dry AMD being the most prevalent form. Programmed cell death of retinal pigment epithelium (RPE) cells is a central mechanism in the pathogene...
Machine Learning Diagnostic Model for Hepatocellular Carcinoma Based on Liquid-Liquid Phase Separation and Ferroptosis-Related Genes.
The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology
Oct 7, 2024
BACKGROUND/AIMS: Hepatocellular carcinoma (HCC) represents a primary liver malignancy with a multifaceted molecular landscape. The interplay between liquid-liquid phase separation (LLPS) and ferroptosis-a regulated form of cell death-has garnered int...
Genetic Analysis of Potential Biomarkers and Therapeutic Targets in Ferroptosis from Steroid-Induced Osteonecrosis of the Femoral Head Based on Machine Learning.
Journal of the College of Physicians and Surgeons--Pakistan : JCPSP
Aug 1, 2024
OBJECTIVE: To locate the candidate therapeutic target genes involved in ferroptosis in steroid-induced osteonecrosis of the femoral head (SONFH).
Machine learning reveals ferroptosis features and a novel ferroptosis classifier in patients with sepsis.
Immunity, inflammation and disease
May 1, 2024
OBJECTIVE: Sepsis is an organ malfunction disease that may become fatal and is commonly accompanied by severe complications such as multiorgan dysfunction. Patients who are already hospitalized have a high risk of death due to sepsis. Even though ear...
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