The limited correlation between mRNA and protein levels within cells highlighted the need to study mechanisms of translational control. To decipher the factors that determine the rates of individual steps in mRNA translation, machine learning approac...
While altered pre-mRNA splicing is a frequent mechanism by which genetic variants cause disease, the regulatory architecture of human exons remains poorly understood. Antisense oligonucleotides (AONs) that target pre-mRNA splicing have been approved ...
Medical oncology (Northwood, London, England)
Aug 30, 2025
As one of the most prevalent malignancies worldwide, colorectal cancer (CRC) exhibits a strong metabolic dependency on glycolysis, which fuels tumor expansion and shapes an immunosuppressive microenvironment. Despite its clinical significance, the re...
Polycystic ovary syndrome (PCOS), a common endocrine condition affecting multiple systems, is tied to atherosclerosis (AS) progression among reproductive-aged women. The present study aimed to explore the underlying associations and uncover potential...
The human microbiome is pivotal in maintaining health and managing diseases. By examining the core microbiome in intensive care units (ICU) patients with pneumonia, we can gain valuable insights into the microbial communities associated with disease ...
BACKGROUND AND PURPOSE: Delta biomarkers that reflect changes in tumour burden over time can support personalised follow-up in head and neck cancer. However, their clinical use can be limited by the need for manual image segmentation. This study exte...
The widespread adoption of generative artificial intelligence (AI) in education and daily life necessitates a deeper understanding of students' awareness and attitudes. However, there is a lack of appropriate and psychometrically validated tools to a...
Bone infections, particularly those caused by Staphylococcus aureus, pose clinical challenges due to biofilm formation and association with bone loss. To address this, we developed a three-dimensional (3D) printed hydrogel-based drug delivery device ...
The Journal of bone and joint surgery. American volume
Aug 29, 2025
BACKGROUND: There is no foundational classification that 3-dimensionally characterizes arthritic anatomy to preoperatively plan and postoperatively evaluate total knee arthroplasty (TKA). With the advent of computed tomography (CT) as a preoperative ...
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