AIMC Topic: Lipids

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ω-3 Fatty Acid Synergized Novel Nanoemulsifying System for Rosuvastatin Delivery: In Vitro and In Vivo Evaluation.

AAPS PharmSciTech Dec 19, 2017
The present study was undertaken to improve rosuvastatin (RSV) bioavailability and pharmacological response through formation of SNES using Perilla frutescens oil as lipid carrier. The composition of oil was estimated by fatty acid methyl ester (FAME...
Rosuvastatin Calcium Emulsions Hypolipidemic Agents Viscosity Perilla frutescens Fatty Acids, Omega-3 Nanostructures Hyperlipidemias Solubility Biological Availability Plant Oils Particle Size Animals Lipids Rats Drug Carriers Tablets
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Evaluation of heterotrophic and mixotrophic cultivation of novel Micractinium sp. ME05 on vinasse and its scale up for biodiesel production.

Bioresource technology Dec 9, 2017
Direct disposal of vinasse, a by-product of molasses fermentation plants, threatens environmental health. This study investigated the usage of vinasse as a nutrient source for the heterotrophic and mixotrophic cultivation of novel Micractinium sp. ME...
Biomass Lipids Microalgae Biofuels Heterotrophic Processes Chlorophyta
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Evaluation of Aristolochia indica L. and Piper nigrum L. methanol extract against centipede Scolopendra moristans L. using Wistar albino rats and screening of bioactive compounds by high pressure liquid chromatography: a polyherbal formulation.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie Nov 28, 2017
The present study was aimed to explore the anti-venom activity of Aristolochia indica and Piper nigrum plants against the centipede (Scolopendra moristans) envenomation in animal model. In vtiro phytochemical, antioxidant and blocking of proteolysis ...
Venoms Phytochemicals Mice Methanol Organ Specificity Antioxidants Humans Chromatography, High Pressure Liquid Phytotherapy Plant Extracts Toxicity Tests, Acute Animals Behavior, Animal Piper nigrum Rats, Wistar Antineoplastic Agents Annelida Proteolysis Lipids Cell Line, Tumor Antivenins Aristolochia Electrolytes
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Advancing the large-scale CCS database for metabolomics and lipidomics at the machine-learning era.

Current opinion in chemical biology Nov 12, 2017
Metabolomics and lipidomics aim to comprehensively measure the dynamic changes of all metabolites and lipids that are present in biological systems. The use of ion mobility-mass spectrometry (IM-MS) for metabolomics and lipidomics has facilitated the...
Mass Spectrometry Metabolomics Lipids Molecular Weight Ion Mobility Spectrometry Machine Learning Databases, Factual
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Combination of mass spectrometry-based targeted lipidomics and supervised machine learning algorithms in detecting adulterated admixtures of white rice.

Food research international (Ottawa, Ont.) Aug 4, 2017
The mixing of extraneous ingredients with original products is a common adulteration practice in food and herbal medicines. In particular, authenticity of white rice and its corresponding blended products has become a key issue in food industry. Acco...
Algorithms Lipids Computational Biology Food Contamination Oryza Mass Spectrometry Supervised Machine Learning
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Machine-Learned Data Structures of Lipid Marker Serum Concentrations in Multiple Sclerosis Patients Differ from Those in Healthy Subjects.

International journal of molecular sciences Jun 7, 2017
Lipid metabolism has been suggested to be a major pathophysiological mechanism of multiple sclerosis (MS). With the increasing knowledge about lipid signaling, acquired data become increasingly complex making bioinformatics necessary in lipid researc...
Eicosanoids Lipids Lipid Metabolism Multiple Sclerosis Informatics Humans Machine Learning Biomarkers Case-Control Studies Ceramides Lysophospholipids
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Simultaneous delivery of anti-miR21 with doxorubicin prodrug by mimetic lipoprotein nanoparticles for synergistic effect against drug resistance in cancer cells.

International journal of nanomedicine Dec 30, 2016
The development of drug resistance in cancer cells is one of the major obstacles to achieving effective chemotherapy. We hypothesized that the combination of a doxorubicin (Dox) prodrug and microRNA (miR)21 inhibitor might show synergistic antitumor ...
Humans Female Animals Antineoplastic Agents Cell Line, Tumor Lipoproteins, HDL Nuclear Localization Signals Receptors, Lipoprotein Lipids MCF-7 Cells Doxorubicin Prodrugs Drug Resistance, Neoplasm Nanoparticles Mice, Nude Apoptosis MicroRNAs
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Contralateral artery enlargement predicts carotid plaque progression based on machine learning algorithm models in apoE mice.

Biomedical engineering online Dec 28, 2016
BACKGROUND: This study specifically focused on anatomical MRI characterization of the low shear stress-induced atherosclerotic plaque in mice. We used machine learning algorithms to analyze multiple correlation factors of plaque to generate predictiv...
Decision Making Lipids Predictive Value of Tests Ultrasonography, Doppler Carotid Arteries Mice Support Vector Machine Magnetic Resonance Imaging Mice, Inbred C57BL Plaque, Atherosclerotic Blood Flow Velocity Mice, Transgenic Apolipoproteins E Machine Learning Algorithms Reproducibility of Results Sensitivity and Specificity Animals Male Disease Progression Ultrasonography
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High Amounts of Sitting, Low Cardiorespiratory Fitness, and Low Physical Activity Levels: 3 Key Ingredients in the Recipe for Influencing Metabolic Syndrome Prevalence.

American journal of health promotion : AJHP Dec 22, 2016
PURPOSE: Limited research has evaluated the independent and additive associations of moderate-to-vigorous physical activity (MVPA), sedentary behavior (SB), and cardiorespiratory fitness (CRF) with metabolic syndrome, which was the purpose of this st...
Humans Female Adiposity Cardiorespiratory Fitness Young Adult Metabolic Syndrome Sitting Position Accelerometry Adult Lipids Sedentary Behavior Cross-Sectional Studies Blood Pressure Prevalence Male Oxygen Consumption Blood Glucose Middle Aged Exercise Test Logistic Models Exercise Nutrition Surveys
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Regulatory efficacy of fermented plant extract on the intestinal microflora and lipid profile in mildly hypercholesterolemic individuals.

Journal of food and drug analysis Dec 3, 2016
In recent years, the use of fermented plant products to protect against various metabolic syndromes has been increasing enormously. The objective of this study was to check the regulatory efficacy of fermented plant extract (FPE) on intestinal microf...
Anticholesteremic Agents Gastrointestinal Microbiome Lipids Intestinal Mucosa Fermentation Hypercholesterolemia Middle Aged Bacteria Plant Extracts Intestines Humans Female Adult Male
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