AIMC Topic: Lipids

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A Combination of Coffee Compounds Shows Insulin-Sensitizing and Hepatoprotective Effects in a Rat Model of Diet-Induced Metabolic Syndrome.

Nutrients Dec 22, 2017
Since coffee may help to prevent the development of metabolic syndrome (MetS), we aimed to evaluate the short- and long-term effects of a coffee-based supplement on different features of diet-induced MetS. In this study, 24 Sprague Dawley rats were d...
Diterpenes Caffeic Acids Carbon-13 Magnetic Resonance Spectroscopy Dietary Sucrose Lipids Coffea Non-alcoholic Fatty Liver Disease Alkaloids Time Factors Insulin Resistance Seeds Rats, Sprague-Dawley Cytokines Animals Blood Glucose Insulin Disease Models, Animal Metabolic Syndrome Dietary Supplements Liver Diet, High-Fat
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Enzymatic preparation of "functional oil" rich in feruloylated structured lipids with solvent-free ultrasound pretreatment.

Food chemistry Dec 19, 2017
In this study, a series of functional oils rich in feruloylated structured lipids (FSLs) was prepared by enzymatic transesterification of ethyl ferulate (EF) with triglycerides under ultrasound pretreatment. A conversion of more than 92.7% and contro...
Antioxidants Solvents Ultrasonics Lipase Triglycerides Caffeic Acids Plant Oils Lipids Kinetics Fatty Acids Esterification
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Circulating triacylglycerols but not pancreatic fat associate with insulin secretion in healthy humans.

Metabolism: clinical and experimental Dec 19, 2017
BACKGROUND: Loss of adequate insulin secretion for the prevailing insulin resistance is critical for the development of type 2 diabetes and has been suggested to result from circulating lipids (triacylglycerols [TG] or free fatty acids) and/or adipoc...
Female Aged Male Middle Aged Insulin Insulin Resistance Lipids Insulin Secretion Humans Adiponectin Insulin-Secreting Cells Fatty Acids, Nonesterified Triglycerides
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ω-3 Fatty Acid Synergized Novel Nanoemulsifying System for Rosuvastatin Delivery: In Vitro and In Vivo Evaluation.

AAPS PharmSciTech Dec 19, 2017
The present study was undertaken to improve rosuvastatin (RSV) bioavailability and pharmacological response through formation of SNES using Perilla frutescens oil as lipid carrier. The composition of oil was estimated by fatty acid methyl ester (FAME...
Hypolipidemic Agents Viscosity Perilla frutescens Fatty Acids, Omega-3 Hyperlipidemias Solubility Biological Availability Emulsions Rosuvastatin Calcium Animals Rats Plant Oils Particle Size Lipids Drug Carriers Tablets Nanostructures
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Evaluation of heterotrophic and mixotrophic cultivation of novel Micractinium sp. ME05 on vinasse and its scale up for biodiesel production.

Bioresource technology Dec 9, 2017
Direct disposal of vinasse, a by-product of molasses fermentation plants, threatens environmental health. This study investigated the usage of vinasse as a nutrient source for the heterotrophic and mixotrophic cultivation of novel Micractinium sp. ME...
Biofuels Heterotrophic Processes Chlorophyta Biomass Lipids Microalgae
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Evaluation of Aristolochia indica L. and Piper nigrum L. methanol extract against centipede Scolopendra moristans L. using Wistar albino rats and screening of bioactive compounds by high pressure liquid chromatography: a polyherbal formulation.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie Nov 28, 2017
The present study was aimed to explore the anti-venom activity of Aristolochia indica and Piper nigrum plants against the centipede (Scolopendra moristans) envenomation in animal model. In vtiro phytochemical, antioxidant and blocking of proteolysis ...
Piper nigrum Proteolysis Venoms Aristolochia Electrolytes Organ Specificity Lipids Phytotherapy Phytochemicals Methanol Chromatography, High Pressure Liquid Behavior, Animal Toxicity Tests, Acute Annelida Antivenins Mice Humans Antioxidants Animals Plant Extracts Antineoplastic Agents Rats, Wistar Cell Line, Tumor
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Advancing the large-scale CCS database for metabolomics and lipidomics at the machine-learning era.

Current opinion in chemical biology Nov 12, 2017
Metabolomics and lipidomics aim to comprehensively measure the dynamic changes of all metabolites and lipids that are present in biological systems. The use of ion mobility-mass spectrometry (IM-MS) for metabolomics and lipidomics has facilitated the...
Mass Spectrometry Metabolomics Lipids Molecular Weight Ion Mobility Spectrometry Machine Learning Databases, Factual
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Combination of mass spectrometry-based targeted lipidomics and supervised machine learning algorithms in detecting adulterated admixtures of white rice.

Food research international (Ottawa, Ont.) Aug 4, 2017
The mixing of extraneous ingredients with original products is a common adulteration practice in food and herbal medicines. In particular, authenticity of white rice and its corresponding blended products has become a key issue in food industry. Acco...
Computational Biology Food Contamination Mass Spectrometry Lipids Algorithms Oryza Supervised Machine Learning
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Machine-Learned Data Structures of Lipid Marker Serum Concentrations in Multiple Sclerosis Patients Differ from Those in Healthy Subjects.

International journal of molecular sciences Jun 7, 2017
Lipid metabolism has been suggested to be a major pathophysiological mechanism of multiple sclerosis (MS). With the increasing knowledge about lipid signaling, acquired data become increasingly complex making bioinformatics necessary in lipid researc...
Multiple Sclerosis Informatics Eicosanoids Humans Machine Learning Biomarkers Lysophospholipids Lipids Lipid Metabolism Case-Control Studies Ceramides
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Simultaneous delivery of anti-miR21 with doxorubicin prodrug by mimetic lipoprotein nanoparticles for synergistic effect against drug resistance in cancer cells.

International journal of nanomedicine Dec 30, 2016
The development of drug resistance in cancer cells is one of the major obstacles to achieving effective chemotherapy. We hypothesized that the combination of a doxorubicin (Dox) prodrug and microRNA (miR)21 inhibitor might show synergistic antitumor ...
Antineoplastic Agents Cell Line, Tumor Nanoparticles Mice, Nude Apoptosis Humans Female Animals Receptors, Lipoprotein Prodrugs Drug Resistance, Neoplasm Lipoproteins, HDL Nuclear Localization Signals MicroRNAs Lipids MCF-7 Cells Doxorubicin
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