The molecular events leading to differentiation, development, and plasticity of lymphoid cells have been subject of intense research due to their key roles in multiple pathologies, such as lymphoproliferative disorders, tumor growth maintenance and c...
Computational intelligence and neuroscience
Jun 2, 2019
This paper presents the recognition for WHO classification of acute lymphoblastic leukaemia (ALL) subtypes. The two ALL subtypes considered are T-lymphoblastic leukaemia (pre-T) and B-lymphoblastic leukaemia (pre-B). They exhibit various characterist...
Journal of visualized experiments : JoVE
Nov 19, 2018
We describe here a protocol for the label-free identification of lymphocyte subtypes using quantitative phase imaging and machine learning. Identification of lymphocyte subtypes is important for the study of immunology as well as diagnosis and treatm...
Cytometry. Part A : the journal of the International Society for Analytical Cytology
May 15, 2018
Cell morphology is often used as a proxy measurement of cell status to understand cell physiology. Hence, interpretation of cell dynamic morphology is a meaningful task in biomedical research. Inspired by the recent success of deep learning, we here ...
Journal of computational biology : a journal of computational molecular cell biology
Apr 25, 2018
Computational analysis of cellular appearance and its dynamics is used to investigate physiological properties of cells in biomedical research. In consideration of the great success of deep learning in video analysis, we first introduce two-stream co...
Paraben is a phenolic derivative of benzoic acid extensively used as preservatives in food, pharmaceutical, and cosmetic industries due to its antimicrobial characteristics. The objective of this study was to evaluate the in vitro genotoxic effects o...
Computer methods and programs in biomedicine
Nov 16, 2017
BACKGROUND AND OBJECTIVES: White blood cells (WBCs) differential counting yields valued information about human health and disease. The current developed automated cell morphology equipments perform differential count which is based on blood smear im...
Identification of lymphocyte cell types are crucial for understanding their pathophysiological roles in human diseases. Current methods for discriminating lymphocyte cell types primarily rely on labelling techniques with magnetic beads or fluorescenc...
Cytometry. Part A : the journal of the International Society for Analytical Cytology
Apr 20, 2017
Digital pathology has led to a demand for automated detection of regions of interest, such as cancerous tissue, from scanned whole slide images. With accurate methods using image analysis and machine learning, significant speed-up, and savings in cos...
To date, studies of biological risk factors have revealed inconsistent relationships with subsequent post-traumatic stress disorder (PTSD). The inconsistent signal may reflect the use of data analytic tools that are ill equipped for modeling the comp...
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