Mice are among the most prevalent animal models used in neuroscience, benefiting from the extensive physiological, imaging, and genetic tools available to study their brain. However, the development of novel and optimized behavioral paradigms for mic...
Phytomedicine : international journal of phytotherapy and phytopharmacology
Sep 15, 2025
BACKGROUND: Parkinson's disease (PD) is a progressive neurodegenerative disorder with increasing global prevalence. Chaihu-shugan-san (CSS) is a Chinese medicine compound with reported neuroprotective properties. However, the precise bioactive consti...
Biochemical and biophysical research communications
Sep 15, 2025
BACKGROUND: Ischemic stroke (IS) accounts for 71 % of all strokes, whose diagnosis and prognosis require further exploration. Neutrophil extracellular traps (NETs) are produced by neutrophils, and there is already evidence that NETs play a role in IS...
Phytomedicine : international journal of phytotherapy and phytopharmacology
Sep 11, 2025
BACKGROUND: The proinflammatory response triggered by macrophages/microglia plays a crucial role in the prognosis of acute ischemic stroke (AIS). Identifying novel targets to regulate the homeostasis of these cells is essential. Developing therapeuti...
Crohn's disease (CD) is a chronic inflammatory bowel condition that significantly impairs patients' quality of life. With no cure currently available, the need to discover novel biomarkers and develop effective therapeutic strategies is paramount. Th...
Environmental stress contributes to the development of depression through neuro-immune interactions, yet the underlying molecular mechanisms and associated clinical diagnostic biomarkers remain unclear. We established a psychosocial stress mouse mode...
BACKGROUND: Protein lactylation has been implicated in stress-responsive cellular mechanisms, yet its role in lung transplantation-associated ischemia-reperfusion injury (IRI) remains undefined.
Naïve T cells are maintained in a homeostatic state to preserve a stable T cell pool with diverse T cell receptor (TCR) repertoires, ensuring preparedness for priming. However, the underlying mechanisms controlling naïve T cell homeostasis and primin...
BACKGROUND: Chronic obstructive pulmonary disease (COPD), mainly caused by cigarette smoke (CS), is a global health concern. Ferroptosis is recognized as a key driver of COPD progression, yet its underlying mechanisms are unclear. This study aimed to...
Biochemical and biophysical research communications
Sep 3, 2025
Abdominal aortic aneurysm (AAA) is a potentially life-threatening vascular condition that currently lacks effective pharmacological treatment. The disease is strongly associated with chronic inflammation, where immune cells like macrophages play a cr...
Join thousands of healthcare professionals staying informed about the latest AI breakthroughs in medicine. Get curated insights delivered to your inbox.