AIMC Topic: Mice, Inbred C57BL

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Predictive reward-prediction errors of climbing fiber inputs integrate modular reinforcement learning with supervised learning.

PLoS computational biology Mar 17, 2025
Although the cerebellum is typically associated with supervised learning algorithms, it also exhibits extensive involvement in reward processing. In this study, we investigated the cerebellum's role in executing reinforcement learning algorithms, wit...
Reward Reinforcement, Psychology Purkinje Cells Mice, Inbred C57BL Supervised Machine Learning Cerebellum Algorithms Animals Male Mice Computational Biology Models, Neurological
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Machine learning-based prediction reveals kinase MAP4K4 regulates neutrophil differentiation through phosphorylating apoptosis-related proteins.

PLoS computational biology Mar 17, 2025
Neutrophils, an essential innate immune cell type with a short lifespan, rely on continuous replenishment from bone marrow (BM) precursors. Although it is established that neutrophils are derived from the granulocyte-macrophage progenitor (GMP), the ...
Humans Neutrophils Apoptosis Mice, Inbred C57BL Protein Serine-Threonine Kinases Machine Learning Animals Mice Computational Biology Intracellular Signaling Peptides and Proteins Phosphorylation Hematopoietic Stem Cells Cell Differentiation Neutropenia Mice, Knockout
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Therapeutic potential of Da Cheng Qi Decoction and its ingredients in regulating ferroptosis via the NOX2-GPX4 signaling pathway to alleviate and predict severe acute pancreatitis.

Cellular signalling Mar 11, 2025
OBJECTIVE: This study aimed to elucidate the protective effects of Da Cheng Qi Decoction (DCQD) on severe acute pancreatitis (SAP) by targeting ferroptosis in pancreatic acinar cells and to establish a predictive signature and nomogram for acute panc...
Humans Ferroptosis Female Drugs, Chinese Herbal Animals Pancreatitis NADPH Oxidase 2 Male Mice Signal Transduction Mice, Inbred C57BL
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Deep Learning Enhanced Near Infrared-II Imaging and Image-Guided Small Interfering Ribonucleic Acid Therapy of Ischemic Stroke.

ACS nano Mar 5, 2025
Small interfering RNA (siRNA) targeting the NOD-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome has emerged as a promising therapeutic strategy to mitigate infarct volume and brain injury following ischemic stroke. However, the cl...
Animals Infrared Rays Male NLR Family, Pyrin Domain-Containing 3 Protein Deep Learning Blood-Brain Barrier Infarction, Middle Cerebral Artery Mice Nanoparticles RNA, Small Interfering Disease Models, Animal Mice, Inbred C57BL Ischemic Stroke
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A deep learning strategy to identify cell types across species from high-density extracellular recordings.

Cell Feb 28, 2025
High-density probes allow electrophysiological recordings from many neurons simultaneously across entire brain circuits but fail to reveal cell type. Here, we develop a strategy to identify cell types from extracellular recordings in awake animals an...
Cerebellum Interneurons Optogenetics Purkinje Cells Mice Rats Mice, Inbred C57BL Neurons Animals Male Deep Learning
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Multi-omics analyses and machine learning prediction of oviductal responses in the presence of gametes and embryos.

eLife Feb 26, 2025
The oviduct is the site of fertilization and preimplantation embryo development in mammals. Evidence suggests that gametes alter oviductal gene expression. To delineate the adaptive interactions between the oviduct and gamete/embryo, we performed a m...
Machine Learning Female Animals Male Embryo, Mammalian Embryonic Development Fallopian Tubes Germ Cells Oviducts Multiomics Transcriptome Single-Cell Analysis Proteomics Mice Mice, Inbred C57BL Spermatozoa
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Identification of hub biomarkers in liver post-metabolic and bariatric surgery using comprehensive machine learning (experimental studies).

International journal of surgery (London, England) Feb 1, 2025
BACKGROUND: The global prevalence of non-alcoholic fatty liver disease (NAFLD) is approximately 30%, and the condition can progress to non-alcoholic steatohepatitis, cirrhosis, and hepatocellular carcinoma. Metabolic and bariatric surgery (MBS) has b...
Non-alcoholic Fatty Liver Disease Bariatric Surgery Disease Models, Animal Mice, Inbred C57BL Liver Lipid Metabolism Animals Male Mice Humans Machine Learning Biomarkers
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Integrating Retinal Segmentation Metrics with Machine Learning for Predictions from Mouse SD-OCT Scans.

Current eye research Jan 23, 2025
PURPOSE: This study aimed to initially test whether machine learning approaches could categorically predict two simple biological features, mouse age and mouse species, using the retinal segmentation metrics.
Retina Mice, Inbred DBA Mice Neural Networks, Computer Support Vector Machine Machine Learning Mice, Inbred C57BL Animals Tomography, Optical Coherence
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Efficient recognition of Parkinson's disease mice on stepping characters with CNN.

Scientific reports Jan 20, 2025
Parkinson's disease (PD), as the second most prevalent neurodegenerative disorder worldwide, impacts the quality of life for over 12 million patients. This study aims to enhance the accuracy of early diagnosis of PD through non-invasive methods, with...
Early Diagnosis Neural Networks, Computer Disease Models, Animal Algorithms Mice, Inbred C57BL Animals Parkinson Disease Image Processing, Computer-Assisted Mice
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Diagnostic Accuracy of Ambient Mass Spectrometry with Blood Plasma in a Murine Glioma Model Using Machine Learning.

World neurosurgery Jan 9, 2025
OBJECTIVE: Malignant glioma progresses rapidly and shows poor prognosis, but clinically applicable blood plasma-based biochemical tumor markers remain lacking. This study aimed to develop a diagnostic system using probe electrospray ionization mass s...
Machine Learning Biomarkers, Tumor Brain Neoplasms Glioma Disease Models, Animal Animals Mice, Inbred C57BL Male Spectrometry, Mass, Electrospray Ionization Cell Line, Tumor Mice
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