AIMC Topic: Mice, Inbred C57BL

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Automated analysis of a novel object recognition test in mice using image processing and machine learning.

Behavioural brain research Sep 30, 2024
The novel object recognition test (NORT) is one of the most commonly employed behavioral tests in experimental animals designed to evaluate an animal's interest in and recognition of novelty. However, manual procedures, which rely on researchers' obs...
Exploratory Behavior Recognition, Psychology Support Vector Machine Mice, Inbred C57BL Machine Learning Behavior, Animal Animals Male Image Processing, Computer-Assisted Mice
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Differential plasma cytokine variation following X-ray or proton brain irradiation using machine-learning approaches.

Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique Sep 21, 2024
PURPOSE: X-ray and proton irradiation have been reported to induce distinct modifications in cytokine expression in vitro and in vivo, suggesting a dissimilar inflammatory response between X-rays and protons. We aimed to investigate the differences i...
Proton Therapy Protons Cranial Irradiation Interleukin-12 Interferon-gamma Interleukin-1alpha Brain Female Animals Male Mice Mice, Inbred C57BL Principal Component Analysis Chemokine CCL2 Machine Learning Cytokines
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Deep-Learning-Driven Discovery of SN3-1, a Potent NLRP3 Inhibitor with Therapeutic Potential for Inflammatory Diseases.

Journal of medicinal chemistry Sep 20, 2024
The NLRP3 inflammasome plays a central role in the pathogenesis of various intractable human diseases, making it an urgent target for therapeutic intervention. Here, we report the development of SN3-1, a novel orally potent NLRP3 inhibitor, designed ...
Humans Mice Inflammation Mice, Inbred C57BL Structure-Activity Relationship Animals Male Drug Discovery Deep Learning NLR Family, Pyrin Domain-Containing 3 Protein Inflammasomes Crystallography, X-Ray
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Salivary detection of Chikungunya virus infection using a portable and sustainable biophotonic platform coupled with artificial intelligence algorithms.

Scientific reports Sep 16, 2024
The current detection method for Chikungunya Virus (CHIKV) involves an invasive and costly molecular biology procedure as the gold standard diagnostic method. Consequently, the search for a non-invasive, more cost-effective, reagent-free, and sustain...
Spectroscopy, Fourier Transform Infrared Artificial Intelligence Mice, Inbred C57BL Algorithms Mice, Knockout Animals Chikungunya virus Saliva Mice Chikungunya Fever
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ARViS: a bleed-free multi-site automated injection robot for accurate, fast, and dense delivery of virus to mouse and marmoset cerebral cortex.

Nature communications Sep 10, 2024
Genetically encoded fluorescent sensors continue to be developed and improved. If they could be expressed across multiple cortical areas in non-human primates, it would be possible to measure a variety of spatiotemporal dynamics of primate-specific c...
Robotics Injections Cerebral Cortex Callithrix Male Biosensing Techniques Mice Mice, Inbred C57BL Female Animals
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A deep learning-based approach for unbiased kinematic analysis in CNS injury.

Experimental neurology Sep 5, 2024
Traumatic spinal cord injury (SCI) is a devastating condition that impacts over 300,000 individuals in the US alone. Depending on the severity of the injury, SCI can lead to varying degrees of sensorimotor deficits and paralysis. Despite advances in ...
Mice Mice, Inbred C57BL Locomotion Spinal Cord Injuries Female Biomechanical Phenomena Animals Deep Learning
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Dynamic changes in pyroptosis following spinal cord injury and the identification of crucial molecular signatures through machine learning and single-cell sequencing.

Journal of pharmaceutical and biomedical analysis Aug 26, 2024
The pathological cascade of spinal cord injury (SCI) is highly intricate. The onset of neuroinflammation can exacerbate the extent of damage. Pyroptosis is a form of inflammation-linked programmed cell death (PCD), the inhibition of pyroptosis can pa...
Cell Line Single-Cell Analysis Machine Learning Neuroinflammatory Diseases Mice Spinal Cord Microglia Disease Models, Animal Animals Spinal Cord Injuries Pyroptosis Mice, Inbred C57BL Male
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Attention-based CNN-BiLSTM for sleep state classification of spatiotemporal wide-field calcium imaging data.

Journal of neuroscience methods Aug 14, 2024
BACKGROUND: Wide-field calcium imaging (WFCI) with genetically encoded calcium indicators allows for spatiotemporal recordings of neuronal activity in mice. When applied to the study of sleep, WFCI data are manually scored into the sleep states of wa...
Mice Mice, Inbred C57BL Electroencephalography Calcium Animals Male Image Processing, Computer-Assisted Attention Wakefulness Sleep Sleep Stages Neural Networks, Computer Brain
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Structured adaptive boosting trees for detection of multicellular aggregates in fluorescence intravital microscopy.

Microvascular research Aug 13, 2024
Fluorescence intravital microscopy captures large data sets of dynamic multicellular interactions within various organs such as the lungs, liver, and brain of living subjects. In medical imaging, edge detection is used to accurately identify and deli...
Blood Platelets Intravital Microscopy Cell Aggregation Mice, Inbred C57BL Predictive Value of Tests Microscopy, Fluorescence Image Interpretation, Computer-Assisted Lung Mice Neutrophils Machine Learning Algorithms Reproducibility of Results Animals
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Mechanisms of QingRe HuoXue Formula in atherosclerosis Treatment: An integrated approach using Bioinformatics, Machine Learning, and experimental validation.

International immunopharmacology Aug 12, 2024
BACKGROUND: Atherosclerosis (AS) is the main cause of coronary heart disease, cerebral infarction, and peripheral vascular disease. QingRe HuoXue Formula (QRHXF), a common prescription of traditional Chinese medicine, has a definite effect on the cli...
Humans Machine Learning Animals Male Molecular Docking Simulation Plaque, Atherosclerotic Collagen Type I Collagen Type I, alpha 1 Chain Disease Models, Animal Mice, Inbred C57BL Gene Expression Profiling Drugs, Chinese Herbal Mice Atherosclerosis Computational Biology
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