AIMC Topic: Nerve Tissue Proteins

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Uncovering the epigenetic regulatory clues of PRRT1 in Alzheimer's disease: a strategy integrating multi-omics analysis with explainable machine learning.

Alzheimer's research & therapy Jan 7, 2025
BACKGROUND: Alzheimer's disease (AD) is a complex neurodegenerative disorder with a largely unexplored epigenetic landscape.
Humans Machine Learning Female Epigenesis, Genetic Epigenomics DNA Methylation Nerve Tissue Proteins Alzheimer Disease Male Gene Expression Profiling Computational Biology Multiomics
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Functional MRGPRX2 expression on peripheral blood-derived human mast cells increases at low seeding density and is suppressed by interleukin-9 and fetal bovine serum.

Frontiers in immunology Dec 13, 2024
Primary human mast cells (MC) obtained through culturing of blood-derived MC progenitors are the preferred model for the study of MRGPRX2- IgE-mediated MC activation. In order to assess the impact of culture conditions on functional MRGPRX2 express...
Interleukin-9 Humans Mast Cells Cells, Cultured Receptors, Neuropeptide Animals Nerve Tissue Proteins Cattle Receptors, G-Protein-Coupled
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Exploring a novel seven-gene marker and mitochondrial gene TMEM38A for predicting cervical cancer radiotherapy sensitivity using machine learning algorithms.

Frontiers in endocrinology Jan 24, 2024
BACKGROUND: Radiotherapy plays a crucial role in the management of Cervical cancer (CC), as the development of resistance by cancer cells to radiotherapeutic interventions is a significant factor contributing to treatment failure in patients. However...
Humans Algorithms Female Nerve Tissue Proteins Uterine Cervical Neoplasms Phosphatidylinositol 3-Kinases Cadherin Related Proteins Genes, Mitochondrial Genetic Markers
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Simulating the restoration of normal gene expression from different thyroid cancer stages using deep learning.

BMC cancer Jun 4, 2022
BACKGROUND: Thyroid cancer (THCA) is the most common endocrine malignancy and incidence is increasing. There is an urgent need to better understand the molecular differences between THCA tumors at different pathologic stages so appropriate diagnostic...
Nerve Tissue Proteins Amino Acid Transport Systems, Neutral Transcriptome Deep Learning Thyroid Neoplasms Gene Expression Regulation, Neoplastic Humans Prognosis
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The Emerging Role of Long Non-Coding RNAs and MicroRNAs in Neurodegenerative Diseases: A Perspective of Machine Learning.

Biomolecules Jul 31, 2021
Neurodegenerative diseases (NDs) are characterized by progressive neuronal dysfunction and death of brain cells population. As the early manifestations of NDs are similar, their symptoms are difficult to distinguish, making the timely detection and d...
Nerve Tissue Proteins Signal Transduction Amyotrophic Lateral Sclerosis Databases, Genetic Internet Parkinson Disease Alzheimer Disease Neurons MicroRNAs Humans Information Dissemination RNA, Long Noncoding Machine Learning Gene Expression Regulation Software Computational Biology
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Machine learning identifies candidates for drug repurposing in Alzheimer's disease.

Nature communications Feb 15, 2021
Clinical trials of novel therapeutics for Alzheimer's Disease (AD) have consumed a large amount of time and resources with largely negative results. Repurposing drugs already approved by the Food and Drug Administration (FDA) for another indication i...
Pharmacogenetics Neuroprotective Agents Nerve Tissue Proteins Drug Repositioning Neurons Humans Machine Learning Severity of Illness Index Gene Expression Profiling Primary Cell Culture Prescription Drugs Nootropic Agents Drugs, Investigational Polypharmacology Alzheimer Disease High-Throughput Screening Assays Gene Expression Regulation Cerebral Cortex
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Identification of contributing genes of Huntington's disease by machine learning.

BMC medical genomics Nov 23, 2020
BACKGROUND: Huntington's disease (HD) is an inherited disorder caused by the polyglutamine (poly-Q) mutations of the HTT gene results in neurodegeneration characterized by chorea, loss of coordination, cognitive decline. However, HD pathogenesis is s...
Nerve Tissue Proteins Sensation Datasets as Topic Linear Models Gene Expression Regulation Gene Expression Profiling Perception Prefrontal Cortex Gene Ontology Inflammation Cytoskeleton Cognition Humans Huntington Disease Decision Trees Machine Learning
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Deep learning approaches for sleep disorder prediction in an asthma cohort.

The Journal of asthma : official journal of the Association for the Care of Asthma Mar 18, 2020
OBJECTIVE: Sleep is a natural activity of humans that affects physical and mental health; therefore, sleep disturbance may lead to fatigue and lower productivity. This study examined 1 million samples included in the Taiwan National Health Insurance ...
DNA-Binding Proteins Sleep Wake Disorders Male Adolescent Middle Aged Artificial Intelligence Humans Child, Preschool Infant Female Child Deep Learning Young Adult Nerve Tissue Proteins Adult Predictive Value of Tests Asthma
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A 21‑gene Support Vector Machine classifier and a 10‑gene risk score system constructed for patients with gastric cancer.

Molecular medicine reports Nov 21, 2019
Gastric cancer (GC) ranks fifth in terms of incidence and third in terms of tumor mortality worldwide. The present study was designed to construct a Support Vector Machine (SVM) classifier and risk score system for GC. The GSE62254 (training set) and...
Gene Expression Regulation, Neoplastic Membrane Proteins Support Vector Machine Databases, Genetic Carrier Proteins Nerve Tissue Proteins Neoplasm Recurrence, Local Tumor Suppressor Proteins Kaplan-Meier Estimate Stomach Neoplasms Male Middle Aged Gene Expression Profiling Humans Gene Regulatory Networks Cytokines Prognosis Angiopoietin-like Proteins Female A Kinase Anchor Proteins Risk Factors Angiopoietin-Like Protein 1 Aged
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Application of artificial neural network model in diagnosis of Alzheimer's disease.

BMC neurology Jul 8, 2019
BACKGROUND: Alzheimer's disease has become a public health crisis globally due to its increasing incidence. The purpose of this study was to establish an early warning model using artificial neural network (ANN) for early diagnosis of AD and to explo...
Peptide Fragments Alzheimer Disease Trace Elements Early Diagnosis Nerve Tissue Proteins Area Under Curve Amyloid beta-Peptides Aged Humans Aged, 80 and over Neural Networks, Computer Sensitivity and Specificity Biomarkers Male Female Case-Control Studies
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