AIMC Topic: Oxidative Stress

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Evidence-based selection of training compounds for use in the mechanism-based integrated prediction of drug-induced liver injury in man.

Archives of toxicology Sep 22, 2016
The current test systems employed by pharmaceutical industry are poorly predictive for drug-induced liver injury (DILI). The 'MIP-DILI' project addresses this situation by the development of innovative preclinical test systems which are both mechanis...
Models, Biological Expert Systems Evidence-Based Medicine Adaptive Immunity Chemical and Drug Induced Liver Injury Hepatobiliary Elimination Oxidative Stress Computational Biology Liver Molecular Structure Lysosomes Drugs, Investigational Mitochondria, Liver Humans Artificial Intelligence Animals Severity of Illness Index
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Temporal changes in plasma markers of oxidative stress following laparoscopic sleeve gastrectomy in subjects with impaired glucose regulation.

Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery Aug 31, 2016
BACKGROUND: Laparoscopic sleeve gastrectomy (LSG) is an effective treatment for obesity and associated metabolic complications. Obesity and type 2 diabetes are associated with increased oxidative stress. Previous studies have examined changes in plas...
Diabetes Mellitus, Type 2 Antioxidants Postoperative Care Laparoscopy Gastrectomy Adult Obesity, Morbid Male Humans Middle Aged Glucose Tolerance Test Prospective Studies Blood Glucose Homeostasis Biomarkers Oxidative Stress Glucose Intolerance Female Thiobarbiturates Young Adult
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An Artificial Neural Network Based Analysis of Factors Controlling Particle Size in a Virgin Coconut Oil-Based Nanoemulsion System Containing Copper Peptide.

PloS one Jul 6, 2016
A predictive model of a virgin coconut oil (VCO) nanoemulsion system for the topical delivery of copper peptide (an anti-aging compound) was developed using an artificial neural network (ANN) to investigate the factors that influence particle size. F...
Plant Oils Particle Size Copper Emulsions Coconut Oil Software Polysaccharides, Bacterial Algorithms Polysorbates Peptides Oxidative Stress Nanoparticles Humans Neural Networks, Computer
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Effects of long-term folate supplementation on metabolic status and regression of cervical intraepithelial neoplasia: A randomized, double-blind, placebo-controlled trial.

Nutrition (Burbank, Los Angeles County, Calif.) Dec 29, 2015
OBJECTIVE: This study was conducted to determine the effects of long-term folate supplementation on regression and metabolic status of patients with cervical intraepithelial neoplasia grade 1 (CIN1).
Humans Female Adult Uterine Cervical Neoplasms Blood Glucose Insulin Oxidative Stress Folic Acid Time Vitamin B Complex Uterine Cervical Dysplasia Insulin Resistance Follow-Up Studies Dietary Supplements C-Reactive Protein Double-Blind Method
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Modified citrus pectin stops progression of liver fibrosis by inhibiting galectin-3 and inducing apoptosis of stellate cells.

Canadian journal of physiology and pharmacology Dec 16, 2015
Modified citrus pectin (MCP) is a pH modified form of the dietary soluble citrus peel fiber known as pectin. The current study aims at testing its effect on liver fibrosis progression. Rats were injected with CCl4 (1 mL/kg, 40% v/v, i.p., twice a wee...
Rats, Sprague-Dawley Apoptosis Dietary Supplements Liver Galectin 3 Animals Male Disease Progression Oxidative Stress Antioxidants Biomarkers Solubility Hepatic Stellate Cells Hot Temperature Hydrogen-Ion Concentration Citrus Dietary Fiber Carbon Tetrachloride Lipid Peroxidation Pectins Fruit Liver Cirrhosis, Experimental
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Effects of pomegranate juice in circulating parameters, cytokines, and oxidative stress markers in endurance-based athletes: A randomized controlled trial.

Nutrition (Burbank, Los Angeles County, Calif.) Dec 7, 2015
OBJECTIVE: The aim of the present study was to assess the effects of pomegranate juice on the level of oxidative stress in the blood of endurance-based athletes. Pomegranate juice is rich in polyphenols, conferring it a higher antioxidant capacity th...
E-Selectin Sports Nutritional Physiological Phenomena Athletes Physical Endurance Adult Stress, Physiological Spain Male Lythraceae Middle Aged Oxidative Stress Antioxidants Malondialdehyde Polyphenols Humans C-Reactive Protein Biomarkers Double-Blind Method Protein Carbonylation Fruit and Vegetable Juices
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Neuroprotective effects of the Phellinus linteus ethyl acetate extract against H2O2-induced apoptotic cell death of SK-N-MC cells.

Nutrition research (New York, N.Y.) Nov 11, 2015
Numerous studies have suggested that neuronal cells are protected against oxidative stress-induced cell damage by antioxidants, such as polyphenolic compounds. Phellinus linteus (PL) has traditionally been used to treat various symptoms in East Asian...
Oxidative Stress Antioxidants Plant Extracts Neuroprotective Agents Apoptosis Biological Products Humans Brain Republic of Korea Cell Line, Tumor Solvents MAP Kinase Signaling System Basidiomycota Fruiting Bodies, Fungal Gene Expression Regulation, Enzymologic Oxidoreductases Ethnopharmacology Polyphenols Medicine, Korean Traditional Nerve Tissue Proteins Phellinus Acetates Polysaccharides Neurons
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Glutathione peroxidase-1 gene (GPX1) variants, oxidative stress and risk of kidney complications in people with type 1 diabetes.

Metabolism: clinical and experimental Oct 28, 2015
BACKGROUND AND AIM: Glutathione peroxidase (GPX) is a class of antioxidant enzymes that catalyze the reduction of hydrogen peroxide to water. GPX1 is the most abundant isoform and is expressed in all kidney cells. Isoprostane and advanced oxidation p...
Glutathione Peroxidase GPX1 Male Middle Aged Oxidative Stress Diabetic Nephropathies Polymorphism, Single Nucleotide Genotype Diabetes Mellitus, Type 1 Glutathione Peroxidase Risk Advanced Oxidation Protein Products Isoprostanes Humans Female Adult
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Small, dense high-density lipoprotein 3 particles exhibit defective antioxidative and anti-inflammatory function in familial hypercholesterolemia: Partial correction by low-density lipoprotein apheresis.

Journal of clinical lipidology Oct 17, 2015
BACKGROUND: Familial hypercholesterolemia (FH) features elevated oxidative stress and accelerated atherosclerosis driven by elevated levels of atherogenic lipoproteins relative to subnormal levels of atheroprotective high-density lipoprotein (HDL). S...
Hyperlipoproteinemia Type II Free Radicals Blood Component Removal Lipoproteins, HDL3 Oxidative Stress Antioxidants Inflammation Particle Size Lipoproteins, LDL Humans Female Adult Male Middle Aged
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Unveiling the role of oxidative stress in ANCA-associated glomerulonephritis through integrated machine learning and bioinformatics analyses.

Renal failure Dec 1, 2025
Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a systemic autoimmune disease often leading to rapidly progressive glomerulonephritis. Oxidative stress plays a critical role in the development and progression of ANCA-associ...
Oxidative Stress Gene Regulatory Networks Computational Biology Databases, Genetic Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis Glomerulonephritis Humans Machine Learning Gene Expression Profiling
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