AIMC Topic: Paclitaxel

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Discovery of mutations predictive of survival benefit from immunotherapy in first-line NSCLC: A retrospective machine learning study of IMpower150 liquid biopsy data.

Computers in biology and medicine Mar 4, 2025
Predictive biomarker identification in cancer treatment has traditionally relied on pre-defined analyses, limiting discoveries to expected biomarkers and potentially overlooking novel ones predictive of therapy response. In this work, we develop a no...
Aged Biomarkers, Tumor Male Middle Aged Lung Neoplasms Humans Machine Learning Retrospective Studies Female Mutation Paclitaxel Liquid Biopsy Clinical Trials, Phase III as Topic Bevacizumab Immunotherapy Antineoplastic Combined Chemotherapy Protocols Carcinoma, Non-Small-Cell Lung Randomized Controlled Trials as Topic
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Machine Learning-Driven Prediction, Preparation, and Evaluation of Functional Nanomedicines Via Drug-Drug Self-Assembly.

Advanced science (Weinheim, Baden-Wurttemberg, Germany) Jan 10, 2025
Small molecules as nanomedicine carriers offer advantages in drug loading and preparation. Selecting effective small molecules for stable nanomedicines is challenging. This study used artificial intelligence (AI) to screen drug combinations for self-...
Machine Learning Drug Delivery Systems Animals Antineoplastic Agents Drug Carriers Anti-Inflammatory Agents, Non-Steroidal Paclitaxel Nanomedicine Indomethacin Humans
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Machine learning and biological validation identify sphingolipids as potential mediators of paclitaxel-induced neuropathy in cancer patients.

eLife Sep 30, 2024
BACKGROUND: Chemotherapy-induced peripheral neuropathy (CIPN) is a serious therapy-limiting side effect of commonly used anticancer drugs. Previous studies suggest that lipids may play a role in CIPN. Therefore, the present study aimed to identify th...
Humans Machine Learning Female Sphingolipids Paclitaxel Lipidomics Peripheral Nervous System Diseases Aged Breast Neoplasms Middle Aged Antineoplastic Agents, Phytogenic
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Noninvasive Computed Tomography-Based Deep Learning Model Predicts In Vitro Chemosensitivity Assay Results in Pancreatic Cancer.

Pancreas Nov 24, 2023
OBJECTIVES: We aimed to predict in vitro chemosensitivity assay results from computed tomography (CT) images by applying deep learning (DL) to optimize chemotherapy for pancreatic ductal adenocarcinoma (PDAC).
Humans Deep Learning Pancreatic Neoplasms Drug Screening Assays, Antitumor Gemcitabine Tomography Fluorouracil Carcinoma, Pancreatic Ductal Paclitaxel Drug Resistance, Neoplasm
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Utilization of circulating cell-free DNA profiling to guide first-line chemotherapy in advanced lung squamous cell carcinoma.

Theranostics Jan 1, 2021
Platinum-based chemotherapy is one of treatment mainstay for patients with advanced lung squamous cell carcinoma (LUSC) but it is still a "one-size fits all" approach. Here, we aimed to investigate the predictive and monitoring role of circulating c...
Circulating Tumor DNA Paclitaxel Progression-Free Survival Deoxycytidine Gemcitabine Survival Rate Male Middle Aged Lung Neoplasms Antineoplastic Combined Chemotherapy Protocols Treatment Outcome Cell-Free Nucleic Acids DNA Copy Number Variations Cisplatin Prognosis Female Carcinoma, Squamous Cell Aged Humans Machine Learning
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Machine Learning Methods to Extract Documentation of Breast Cancer Symptoms From Electronic Health Records.

Journal of pain and symptom management Feb 27, 2018
CONTEXT: Clinicians document cancer patients' symptoms in free-text format within electronic health record visit notes. Although symptoms are critically important to quality of life and often herald clinical status changes, computational methods to a...
Nausea Fatigue Machine Learning Electronic Health Records Female Breast Neoplasms Middle Aged Cohort Studies Antineoplastic Agents, Phytogenic Pain Paclitaxel Humans
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Development of a Competitive Time-Resolved Fluoroimmunoassay for Paclitaxel.

Phytochemical analysis : PCA Dec 20, 2017
INTRODUCTION: Paclitaxel (Tax) is a diterpene alkaloid isolated from Taxus species and has proved clinically effective in treating a number of malignancies. Current quantitative analytical methods for Tax such as high-performance liquid chromatograph...
Rabbits Enzyme-Linked Immunosorbent Assay Paclitaxel Calibration Antineoplastic Agents, Phytogenic Humans Fluorescent Antibody Technique Antibodies, Monoclonal Immunoglobulin G Taxus Limit of Detection Reproducibility of Results Time and Motion Studies Animals
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Label-free detection of cellular drug responses by high-throughput bright-field imaging and machine learning.

Scientific reports Sep 29, 2017
In the last decade, high-content screening based on multivariate single-cell imaging has been proven effective in drug discovery to evaluate drug-induced phenotypic variations. Unfortunately, this method inherently requires fluorescent labeling which...
Humans Machine Learning Image Processing, Computer-Assisted Microfluidics High-Throughput Screening Assays Cell Shape Microscopy, Interference Dose-Response Relationship, Drug Antineoplastic Agents, Phytogenic MCF-7 Cells Paclitaxel
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COF-1-modified magnetic nanoparticles for highly selective and efficient solid-phase microextraction of paclitaxel.

Talanta Dec 21, 2016
Novel covalent organic framework-1 modified magnetic nanoparticles (M-COF-1) were prepared for extraction of paclitaxel from rat plasma samples. Paclitaxel is an important anti-cancer drug in clinical chemotherapy. COF-1 was immobilized on the surfac...
Metal-Organic Frameworks Polymers Hydrogen-Ion Concentration Paclitaxel Indoles Solid Phase Microextraction Adsorption Antineoplastic Agents, Phytogenic Limit of Detection Magnetite Nanoparticles Animals Rats
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Efficacy according to blind independent central review: Post-hoc analyses from the phase III, randomized, multicenter, IPASS study of first-line gefitinib versus carboplatin/paclitaxel in Asian patients with EGFR mutation-positive advanced NSCLC.

Lung cancer (Amsterdam, Netherlands) Nov 30, 2016
OBJECTIVE: The Phase III, randomized, open-label IPASS study (NCT00322452) of first-line epidermal growth factor receptor tyrosine kinase inhibitor (EGFR TKI) gefitinib versus carboplatin/paclitaxel for Asian patients with advanced non-small-cell lun...
Lung Neoplasms Antineoplastic Combined Chemotherapy Protocols Adenocarcinoma Carcinoma, Non-Small-Cell Lung Humans Randomized Controlled Trials as Topic Female Aged Aged, 80 and over Male Middle Aged Antineoplastic Agents Paclitaxel Disease-Free Survival Neoplasm Staging Smoking Mutation ErbB Receptors Asian People Protein Kinase Inhibitors Carboplatin Gefitinib Quinazolines
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