AIMC Topic: Reactive Oxygen Species
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Cytotoxic response of platinum-coated gold nanorods in human breast cancer cells at very low exposure levels.
Environmental toxicology
Apr 6, 2015
Because of unique optical behavior gold nanorods (GNRs) have attracted attention for the application in biomedical field such as bio-sensing, bio-imaging and hyperthermia. However, toxicological response of GNRs is controversial due to their differen...
G1 Phase Cell Cycle Checkpoints
Humans
Female
RNA, Messenger
Apoptosis
Breast Neoplasms
Real-Time Polymerase Chain Reaction
Platinum
Proto-Oncogene Proteins c-bcl-2
Down-Regulation
Acetylcysteine
Caspase 9
MCF-7 Cells
Up-Regulation
Reactive Oxygen Species
Gold
Nanotubes
Caspase 3
Membrane Potential, Mitochondrial
Particle Size
Quantifying small molecule phenotypic effects using mitochondrial morpho-functional fingerprinting and machine learning.
Scientific reports
Jan 26, 2015
In primary fibroblasts from Leigh Syndrome (LS) patients, isolated mitochondrial complex I deficiency is associated with increased reactive oxygen species levels and mitochondrial morpho-functional changes. Empirical evidence suggests these aberratio...
Predicting in vitro assays related to liver function using probabilistic machine learning.
Toxicology
Sep 1, 2025
While machine learning has gained traction in toxicological assessments, the limited data availability requires the quantification of uncertainty of in silico predictions for reliable decision-making. This study addresses the challenge of predicting ...
Screening of oxidative stress components of cigarette smoke based on machine learning model integration.
Toxicology and applied pharmacology
Jul 1, 2025
Cigarette smoke, a complex mixture of more than 7000 chemicals, poses a significant threat to human health, with oxidative stress being an important mechanism in its associated diseases. Traditional methods for assessing the toxicity of cigarette smo...
Machine learning-guided fabrication of carbon dot-pepsin nano-conjugates for enhanced bioimaging, synergistic drug delivery, and visible light-induced photosensitization.
Nanoscale
Jun 12, 2025
Carbon dots (CDs) are emerging as next-generation bioimaging agents due to their strong fluorescence, photobleaching resistance, and biocompatibility. However, their small size often limits efficient cell internalization, leading to unspecified cellu...
Human Retinal Organoids in Therapeutic Discovery: A Review of Applications.
Handbook of experimental pharmacology
Jan 1, 2023
Human embryonic stem cells (hESCs)- and induced pluripotent stem cells (hiPSCs)-derived retinal organoids (ROs) are three-dimensional laminar structures that recapitulate the developmental trajectory of the human retina. The ROs provide a fascinating...
Single-model multi-tasks deep learning network for recognition and quantitation of surface-enhanced Raman spectroscopy.
Optics express
Nov 7, 2022
Surface-enhanced Raman scattering (SERS) spectroscopy analysis has long been the central task of nanoscience and nanotechnology to realize the ultrasensitive recognition/quantitation applications. Recently, the blooming of artificial intelligence alg...
Toxic activity of Prunus spinosa L. flower extract in hepatocarcinoma cells.
Arhiv za higijenu rada i toksikologiju
Dec 1, 2019
Prunus spinosa L. (blackthorn) is used in traditional medicine as a remedy for various diseases. To establish its anticancer properties, we exposed human liver cancer cells (Hep G2) to a range of blackthorn flower extract concentrations (10-200 µg/mL...
[Effect of dihydroartemisinin on multidrug resistance of human oral squamous cell carcinoma cell line KBV200 by regulating ROS-MAPK pathway].
Shanghai kou qiang yi xue = Shanghai journal of stomatology
Dec 1, 2019
PURROSE: To investigate the effect of dihydroartemisinin (DHA) on multidrug resistance of human oral squamous cell carcinoma cell line KBV200 and to explore its relationship with ROS-MAPK pathway.
Neuroprotective effects of Suhexiang Wan on the in vitro and in vivo models of Parkinson's disease.
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan
Dec 1, 2019
OBJECTIVE: To examine the role of KSOP1009 (a modified formulation of Suhexiang Wan essential oil) in an animal model of Parkinson's disease (PD) induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) injection.
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