AIMC Topic: Animals, Genetically Modified

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Niuhuang jiedu prescription alleviates realgar-induced dopaminergic and GABAergic neurotoxicity in Caenorhabditis elegans.

Journal of ethnopharmacology Apr 2, 2025
ETHNOPHARMACOLOGICAL RELEVANCE: Niuhuang Jiedu (NHJD) is a Chinese medicine prescription containing realgar (AsS), which is neurotoxic, and seven other traditional Chinese medicines (TCMs). However, whether the multiple TCMs contained in NHJD can mit...
Drugs, Chinese Herbal Sulfides Animals, Genetically Modified Behavior, Animal Locomotion Animals Neurotoxicity Syndromes Oxidative Stress Caenorhabditis elegans Neuroprotective Agents Reactive Oxygen Species Caenorhabditis elegans Proteins Dopaminergic Neurons GABAergic Neurons Arsenicals
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Cell-type-directed design of synthetic enhancers.

Nature Dec 12, 2023
Transcriptional enhancers act as docking stations for combinations of transcription factors and thereby regulate spatiotemporal activation of their target genes. It has been a long-standing goal in the field to decode the regulatory logic of an enhan...
Humans Brain Animals Drosophila melanogaster Cells Deep Learning Repressor Proteins Transcription Factors Neuroglia Animals, Genetically Modified Enhancer Elements, Genetic Synthetic Biology Gene Expression Regulation
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Establishment of a morphological atlas of the Caenorhabditis elegans embryo using deep-learning-based 4D segmentation.

Nature communications Dec 7, 2020
The invariant development and transparent body of the nematode Caenorhabditis elegans enables complete delineation of cell lineages throughout development. Despite extensive studies of cell division, cell migration and cell fate differentiation, cell...
Caenorhabditis elegans Software Morphogenesis Animals Deep Learning Animals, Genetically Modified Imaging, Three-Dimensional Embryo, Nonmammalian Computational Biology Green Fluorescent Proteins Cell Movement Cell Lineage Cell Differentiation Microscopy, Fluorescence Embryonic Development
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Artificial intelligence and network pharmacology based investigation of pharmacological mechanism and substance basis of Xiaokewan in treating diabetes.

Pharmacological research May 25, 2020
Xiaokewan is a typical Traditional Chinese medicine (TCM) for diabetes and contains various natural chemicals, such as lignans, flavonoids, saponins, polysaccharides, and western medicine glibenclamide. In the current study, a highly efficient system...
Spectrometry, Mass, Electrospray Ionization Animals, Genetically Modified Zebrafish Chromatography, High Pressure Liquid Tandem Mass Spectrometry Data Mining Blood Glucose Protein Interaction Maps Gene Regulatory Networks Systems Biology Rats, Wistar Hypoglycemic Agents Diabetes Mellitus Disease Models, Animal Drugs, Chinese Herbal Workflow Artificial Intelligence Biomarkers Animals Male
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CytoCensus, mapping cell identity and division in tissues and organs using machine learning.

eLife May 19, 2020
A major challenge in cell and developmental biology is the automated identification and quantitation of cells in complex multilayered tissues. We developed CytoCensus: an easily deployed implementation of supervised machine learning that extends conv...
Machine Learning Phenotype Brain Time Factors Image Processing, Computer-Assisted Mice Mutation Retina Female Reproducibility of Results Animals Male Larva Organoids Zebrafish Drosophila melanogaster Embryo, Mammalian Cell Division Animals, Genetically Modified Tissue Culture Techniques Automation Time-Lapse Imaging Microscopy, Video
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Utilizing supervised machine learning to identify microglia and astrocytes in situ: implications for large-scale image analysis and quantification.

Journal of neuroscience methods Sep 5, 2019
BACKGROUND: The evaluation of histological tissue samples plays a crucial role in deciphering preclinical disease and injury mechanisms. High-resolution images can be obtained quickly however data acquisition are often bottlenecked by manual analysis...
Neurosciences Reproducibility of Results Supervised Machine Learning Sensitivity and Specificity Animals, Genetically Modified Image Processing, Computer-Assisted Animals Fluorescent Antibody Technique Mice Histological Techniques Rats Microglia Astrocytes
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Multiple tracking and machine learning reveal dopamine modulation for area-restricted foraging behaviors via velocity change in Caenorhabditis elegans.

Neuroscience letters May 10, 2019
Food exploration is an essential survival behavior in organisms. To find food efficiently, many organisms use a foraging strategy called area-restricted search (ARS) wherein individuals first turn more frequently, restricting their search to one area...
Reinforcement, Psychology Appetitive Behavior Machine Learning Animals Animals, Genetically Modified Dopamine Caenorhabditis elegans
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High-throughput brain activity mapping and machine learning as a foundation for systems neuropharmacology.

Nature communications Dec 3, 2018
Technologies for mapping the spatial and temporal patterns of neural activity have advanced our understanding of brain function in both health and disease. An important application of these technologies is the discovery of next-generation neurotherap...
Machine Learning Brain Animals Larva Disease Models, Animal Brain Mapping Molecular Structure Pentylenetetrazole Seizures Drug Evaluation, Preclinical Zebrafish Animals, Genetically Modified Convulsants Neuropharmacology
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Determination of total plasma oxysterols by enzymatic hydrolysis, solid phase extraction and liquid chromatography coupled to mass-spectrometry.

Journal of pharmaceutical and biomedical analysis Dec 21, 2017
The potential use of cholesterol esterases was tested to avoid alkaline hydrolysis for cleavage of plasma esterified oxysterols. The enzymatic hydrolysis was optimized by testing two sources of enzyme-Pseudomonas and bovine pancreas, presence of surf...
Hydrolysis Chromatography, Liquid Humans Bacterial Proteins Animals, Genetically Modified Cytochrome P450 Family 7 Reproducibility of Results Calibration Tandem Mass Spectrometry Oxysterols Animals Reference Standards Pseudomonas aeruginosa Rats, Inbred F344 Male Solid Phase Extraction Steroid Hydroxylases Sterol Esterase
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Transcriptomes of lineage-specific Drosophila neuroblasts profiled by genetic targeting and robotic sorting.

Development (Cambridge, England) Dec 23, 2015
A brain consists of numerous distinct neurons arising from a limited number of progenitors, called neuroblasts in Drosophila. Each neuroblast produces a specific neuronal lineage. To unravel the transcriptional networks that underlie the development ...
Drosophila Proteins Animals Drosophila melanogaster Transcription Factors Transcriptome Cell Lineage Robotics Single-Cell Analysis Gene Expression Regulation, Developmental Neurons Sequence Analysis, RNA Gene Targeting Animals, Genetically Modified
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