Collecting phenotypic data from many individuals is critical to answering fundamental biological questions, particularly in genetics. Yet, whole organismal phenotypic data are still often collected manually; limiting the scale of data generation, pre...
UNLABELLED: Identifying functionally important cell states and structure within heterogeneous tumors remains a significant biological and computational challenge. Current clustering- or trajectory-based models are ill-equipped to address the notion t...
Neurological disorders result from the complex and poorly understood contributions of many cell types. It is therefore essential to uncover mechanisms behind these disorders and identify specific therapeutic targets. Single-nucleus technologies have ...
Schistosomiasis, caused by Schistosoma mansoni, remains a significant public health burden, particularly in endemic regions with limited access to effective treatment. The emergence of resistance to praziquantel necessitates the urgent discovery of n...
Osteoinduction is an important feature of the next generation of bone repair materials. But the key structural factors and parameters of osteoinductive scaffolds are not yet clarified. This study leverages the efficiency of high-throughput screening ...
BACKGROUND: Relapse and drug resistance are major contributor to chemotherapy failure in diffuse large B-cell lymphoma (DLBCL). Programmed cell death (PCD), a key mechanism in tumor progression and resistance, has emerged as a promising biomarker for...
Vascular dementia (VaD), the second most common form of dementia, lacks reliable biomarkers for early diagnosis. Here, we integrated weighted gene co-expression network analysis (WGCNA) with machine learning to identify novel biomarkers and immune-me...
OBJECTIVE: Fish disease in aquaculture is a major risk to food safety. The identification of infected fish and disease categories present in fish farms remains difficult to determine at an early stage. Detecting infected fish in time is an essential ...
BACKGROUND: Brachycephalic dog breeds often exhibit a suite of extreme conformations linked with several severe and long-term disorders. Despite this, ownership levels of brachycephalic breeds remain high internationally, with physical appearance bei...
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Sep 15, 2025
Myocardial infarction (MI) is a leading cause of death worldwide and the most common precursor to heart failure, even after initial treatment. Precise evaluation of myocardial injury is crucial for assessing interventions and improving outcomes. Exte...
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