AIMC Topic: Antineoplastic Combined Chemotherapy Protocols

Clear Filters Showing 71 to 80 of 143 articles

Prediction of irinotecan toxicity in metastatic colorectal cancer patients based on machine learning models with pharmacokinetic parameters.

Journal of pharmacological sciences May 4, 2019
Irinotecan (CPT-11) is a drug used against a wide variety of tumors, which can cause severe toxicity, possibly leading to the delay or suspension of the cycle, with the consequent impact on the prognosis of survival. The main goal of this work is to ...
Forecasting Female Aged Colorectal Neoplasms Male Middle Aged Humans Machine Learning Camptothecin Topoisomerase I Inhibitors Irinotecan Leucovorin Glucuronates Neutropenia Diarrhea Antineoplastic Combined Chemotherapy Protocols Oxaliplatin Models, Biological Fluorouracil Leukopenia
View on PubMed DOI

Multivariate machine learning models for prediction of pathologic response to neoadjuvant therapy in breast cancer using MRI features: a study using an independent validation set.

Breast cancer research and treatment Oct 16, 2018
PURPOSE: To determine whether a multivariate machine learning-based model using computer-extracted features of pre-treatment dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) can predict pathologic complete response (pCR) to neoadjuvant ...
Feasibility Studies Receptor, ErbB-2 Mastectomy, Segmental Adult Middle Aged ROC Curve Image Processing, Computer-Assisted Triple Negative Breast Neoplasms Antineoplastic Combined Chemotherapy Protocols Treatment Outcome Neoadjuvant Therapy Magnetic Resonance Imaging Neoplasm Staging Breast Humans Machine Learning Retrospective Studies Female Aged
View on PubMed DOI

Predict effective drug combination by deep belief network and ontology fingerprints.

Journal of biomedical informatics Aug 3, 2018
The synergistic effect of drug combination is one of the most desirable properties for treating cancer. However, systematically predicting effective drug combination is a significant challenge. We report here a novel method based on deep belief netwo...
Databases, Pharmaceutical Computational Biology Antineoplastic Combined Chemotherapy Protocols Drug Combinations Drug Synergism Gene Ontology Humans Neoplasms Gene Expression Profiling Deep Learning Cell Line, Tumor Gene Regulatory Networks
View on PubMed DOI

Immunomarker Support Vector Machine Classifier for Prediction of Gastric Cancer Survival and Adjuvant Chemotherapeutic Benefit.

Clinical cancer research : an official journal of the American Association for Cancer Research Jul 24, 2018
Current tumor-node-metastasis (TNM) staging system cannot provide adequate information for prediction of prognosis and chemotherapeutic benefits. We constructed a classifier to predict prognosis and identify a subset of patients who can benefit from...
Chemotherapy, Adjuvant Support Vector Machine Neoplasm Staging Neoplasm Grading Survival Analysis Tumor Burden Immunohistochemistry Male Middle Aged ROC Curve Antineoplastic Combined Chemotherapy Protocols Treatment Outcome Humans Prognosis Female Aged Stomach Neoplasms Biomarkers, Tumor
View on PubMed DOI

Predicting Post Neoadjuvant Axillary Response Using a Novel Convolutional Neural Network Algorithm.

Annals of surgical oncology Jul 5, 2018
OBJECTIVES: In the postneoadjuvant chemotherapy (NAC) setting, conventional radiographic complete response (rCR) is a poor predictor of pathologic complete response (pCR) of the axilla. We developed a convolutional neural network (CNN) algorithm to b...
Antineoplastic Combined Chemotherapy Protocols Neoadjuvant Therapy Follow-Up Studies Magnetic Resonance Imaging Neoplasm Invasiveness Axilla Survival Rate Breast Neoplasms Biomarkers, Tumor Middle Aged ROC Curve Receptor, ErbB-2 Carcinoma, Ductal, Breast Receptors, Estrogen Chemotherapy, Adjuvant Carcinoma, Lobular Humans Neural Networks, Computer Algorithms Prognosis Retrospective Studies Female Aged Aged, 80 and over Young Adult Adult
View on PubMed DOI

Vitamin D deficiency and supplementation in patients with aggressive B-cell lymphomas treated with immunochemotherapy.

Cancer medicine Dec 22, 2017
Vitamin D deficiency has been reported to be a negative prognostic factor in elderly patients with aggressive B-cell lymphomas. In vitro data suggest that vitamin D supplementation may enhance rituximab-mediated cytotoxicity. We prospectively assesse...
Prednisone Rituximab Vincristine Dietary Supplements Disease-Free Survival Doxorubicin Cyclophosphamide Cholecalciferol Middle Aged Immunotherapy Antineoplastic Combined Chemotherapy Protocols Treatment Outcome Vitamin D Vitamin D Deficiency Humans Female Aged Lymphoma, Large B-Cell, Diffuse Male
View on PubMed DOI

Seven-Month Prostate-Specific Antigen Is Prognostic in Metastatic Hormone-Sensitive Prostate Cancer Treated With Androgen Deprivation With or Without Docetaxel.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology Dec 20, 2017
Purpose We evaluated the relationship between prostate-specific antigen (PSA) and overall survival in the context of a prospectively randomized clinical trial comparing androgen-deprivation therapy (ADT) plus docetaxel with ADT alone for initial meta...
Humans Databases, Factual Retrospective Studies Androgen Antagonists Docetaxel Neoplasm Metastasis Kallikreins Neoplasms, Hormone-Dependent Time Factors Antineoplastic Combined Chemotherapy Protocols Treatment Outcome Aged Randomized Controlled Trials as Topic Aged, 80 and over Prostatic Neoplasms Adult Prostate-Specific Antigen Male Middle Aged
View on PubMed DOI

5-fluorouracil combined with cisplatin and mitomycin C as an optimized regimen for hyperthermic intraperitoneal chemotherapy in gastric cancer.

Journal of surgical oncology Dec 19, 2017
BACKGROUND AND OBJECTIVES: Optimized drug regimens for hyperthermic intraperitoneal chemotherapy (HIPEC) have not been standardized completely in patients with advanced gastric cancer (GC). We evaluated an optimized anti-tumor protocol comprising 5-f...
Humans Antineoplastic Combined Chemotherapy Protocols Stomach Neoplasms Dose-Response Relationship, Drug Drug Screening Assays, Antitumor Cisplatin Fluorouracil Mitomycin Hyperthermia, Induced Cell Growth Processes Cell Line, Tumor
View on PubMed DOI

Serum Vitamin D Levels Affect Pathologic Complete Response in Patients Undergoing Neoadjuvant Systemic Therapy for Operable Breast Cancer.

Clinical breast cancer Dec 11, 2017
INTRODUCTION: There has been increasing interest in the potential benefit of vitamin D in improving breast cancer outcome. Preclinical studies suggest that vitamin D enhances chemotherapy-induced cell death. We investigated the impact of serum vitami...
Lymph Nodes Humans Apoptosis Antineoplastic Combined Chemotherapy Protocols Retrospective Studies Breast Treatment Outcome Female Mastectomy Neoadjuvant Therapy Breast Neoplasms France Vitamin D Middle Aged Iowa Vitamin D Deficiency
View on PubMed DOI

Characterizing Autoimmune Disease-associated Diffuse Large B-cell Lymphoma in a SEER-Medicare Cohort.

Clinical lymphoma, myeloma & leukemia Dec 2, 2017
BACKGROUND: Severe immune dysregulation such as seen in autoimmune (AI) disease is known to act as a significant risk factor for diffuse large B-cell lymphoma (DLBCL). However, little is known about the demographics or clinical outcomes of DLBCL that...
Lupus Erythematosus, Systemic Medicare Humans Autoimmune Diseases Retrospective Studies SEER Program Female Survival Analysis Aged Male Sjogren's Syndrome Aged, 80 and over Comorbidity Lymphoma, Large B-Cell, Diffuse Arthritis, Rheumatoid United States Antineoplastic Combined Chemotherapy Protocols
View on PubMed DOI
Popular Topics
Recent Journals