AIMC Topic: Antineoplastic Combined Chemotherapy Protocols

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Vitamin D deficiency and supplementation in patients with aggressive B-cell lymphomas treated with immunochemotherapy.

Cancer medicine Dec 22, 2017
Vitamin D deficiency has been reported to be a negative prognostic factor in elderly patients with aggressive B-cell lymphomas. In vitro data suggest that vitamin D supplementation may enhance rituximab-mediated cytotoxicity. We prospectively assesse...
Vincristine Doxorubicin Cyclophosphamide Cholecalciferol Prednisone Rituximab Treatment Outcome Vitamin D Vitamin D Deficiency Dietary Supplements Aged Disease-Free Survival Lymphoma, Large B-Cell, Diffuse Male Middle Aged Immunotherapy Antineoplastic Combined Chemotherapy Protocols Humans Female
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Seven-Month Prostate-Specific Antigen Is Prognostic in Metastatic Hormone-Sensitive Prostate Cancer Treated With Androgen Deprivation With or Without Docetaxel.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology Dec 20, 2017
Purpose We evaluated the relationship between prostate-specific antigen (PSA) and overall survival in the context of a prospectively randomized clinical trial comparing androgen-deprivation therapy (ADT) plus docetaxel with ADT alone for initial meta...
Time Factors Antineoplastic Combined Chemotherapy Protocols Treatment Outcome Randomized Controlled Trials as Topic Prostatic Neoplasms Neoplasm Metastasis Kallikreins Neoplasms, Hormone-Dependent Prostate-Specific Antigen Aged Androgen Antagonists Aged, 80 and over Humans Docetaxel Adult Databases, Factual Male Retrospective Studies Middle Aged
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5-fluorouracil combined with cisplatin and mitomycin C as an optimized regimen for hyperthermic intraperitoneal chemotherapy in gastric cancer.

Journal of surgical oncology Dec 19, 2017
BACKGROUND AND OBJECTIVES: Optimized drug regimens for hyperthermic intraperitoneal chemotherapy (HIPEC) have not been standardized completely in patients with advanced gastric cancer (GC). We evaluated an optimized anti-tumor protocol comprising 5-f...
Humans Stomach Neoplasms Cell Line, Tumor Antineoplastic Combined Chemotherapy Protocols Dose-Response Relationship, Drug Drug Screening Assays, Antitumor Cisplatin Fluorouracil Mitomycin Hyperthermia, Induced Cell Growth Processes
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Serum Vitamin D Levels Affect Pathologic Complete Response in Patients Undergoing Neoadjuvant Systemic Therapy for Operable Breast Cancer.

Clinical breast cancer Dec 11, 2017
INTRODUCTION: There has been increasing interest in the potential benefit of vitamin D in improving breast cancer outcome. Preclinical studies suggest that vitamin D enhances chemotherapy-induced cell death. We investigated the impact of serum vitami...
Vitamin D Deficiency Iowa Lymph Nodes Humans Apoptosis Retrospective Studies Antineoplastic Combined Chemotherapy Protocols Breast Female Treatment Outcome Mastectomy Breast Neoplasms Neoadjuvant Therapy France Middle Aged Vitamin D
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Characterizing Autoimmune Disease-associated Diffuse Large B-cell Lymphoma in a SEER-Medicare Cohort.

Clinical lymphoma, myeloma & leukemia Dec 2, 2017
BACKGROUND: Severe immune dysregulation such as seen in autoimmune (AI) disease is known to act as a significant risk factor for diffuse large B-cell lymphoma (DLBCL). However, little is known about the demographics or clinical outcomes of DLBCL that...
United States Antineoplastic Combined Chemotherapy Protocols Lupus Erythematosus, Systemic Medicare Humans Autoimmune Diseases Retrospective Studies Aged, 80 and over Female Lymphoma, Large B-Cell, Diffuse Aged Male SEER Program Comorbidity Survival Analysis Arthritis, Rheumatoid Sjogren's Syndrome
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PAK6-Associated Support Vector Machine Classifier: A New Way to Evaluate Response and Survival of Gastric Cancer Treated by 5-FU/Oxaliplatin Chemotherapy.

EBioMedicine Jul 5, 2017
Antineoplastic Combined Chemotherapy Protocols Oxaliplatin Support Vector Machine Fluorouracil Organoplatinum Compounds p21-Activated Kinases Humans Stomach Neoplasms Colorectal Neoplasms
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Prediction of synergistic anti-cancer drug combinations based on drug target network and drug induced gene expression profiles.

Artificial intelligence in medicine Jun 3, 2017
OBJECTIVE: Synergistic drug combinations are promising therapies for cancer treatment. However, effective prediction of synergistic drug combinations is quite challenging as mechanisms of drug synergism are still unclear. Various features such as dru...
Gene Regulatory Networks Computational Biology Gene Expression Regulation, Neoplastic Signal Transduction Antineoplastic Combined Chemotherapy Protocols Neoplasms Gene Expression Profiling Transcriptome Pharmacogenetics Protein Interaction Maps Humans Databases, Genetic Artificial Intelligence Drug Synergism Computer Simulation Reproducibility of Results
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Correlation of Serum Cystatin C with Glomerular Filtration Rate in Patients Receiving Platinum-Based Chemotherapy.

Analytical cellular pathology (Amsterdam) Dec 18, 2016
. Serum cystatin C seems to be an accurate marker of glomerular filtration rate (GFR) compared to serum creatinine. The aim of this work was to explore the possibility of using serum cystatin C instead of serum creatinine to early predict renal failu...
Prognosis Female Aged Adult Sensitivity and Specificity Humans Biomarkers Cystatin C Creatinine Cisplatin Carboplatin Renal Insufficiency Male Middle Aged Neoplasms Antineoplastic Combined Chemotherapy Protocols Glomerular Filtration Rate
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Computational prediction of multidisciplinary team decision-making for adjuvant breast cancer drug therapies: a machine learning approach.

BMC cancer Dec 1, 2016
BACKGROUND: Multidisciplinary team (MDT) meetings are used to optimise expert decision-making about treatment options, but such expertise is not digitally transferable between centres. To help standardise medical decision-making, we developed a machi...
Humans Models, Theoretical Antineoplastic Combined Chemotherapy Protocols Combined Modality Therapy Supervised Machine Learning Aged Machine Learning Chemotherapy, Adjuvant Aged, 80 and over Algorithms Patient Care Team Adult Computer Simulation Breast Neoplasms Clinical Decision-Making Middle Aged Female
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Efficacy according to blind independent central review: Post-hoc analyses from the phase III, randomized, multicenter, IPASS study of first-line gefitinib versus carboplatin/paclitaxel in Asian patients with EGFR mutation-positive advanced NSCLC.

Lung cancer (Amsterdam, Netherlands) Nov 30, 2016
OBJECTIVE: The Phase III, randomized, open-label IPASS study (NCT00322452) of first-line epidermal growth factor receptor tyrosine kinase inhibitor (EGFR TKI) gefitinib versus carboplatin/paclitaxel for Asian patients with advanced non-small-cell lun...
Protein Kinase Inhibitors Gefitinib Quinazolines Carcinoma, Non-Small-Cell Lung Randomized Controlled Trials as Topic Neoplasm Staging Mutation Asian People Carboplatin Paclitaxel Disease-Free Survival Smoking ErbB Receptors Middle Aged Antineoplastic Agents Lung Neoplasms Antineoplastic Combined Chemotherapy Protocols Adenocarcinoma Humans Female Aged Aged, 80 and over Male
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