AIMC Topic: Computational Biology
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TransRM: Weakly supervised learning of translation-enhancing N6-methyladenosine (mA) in circular RNAs.
International journal of biological macromolecules
Feb 27, 2025
As our understanding of Circular RNAs (circRNAs) continues to expand, accumulating evidence has demonstrated that circRNAs can interact with microRNAs and RNA-binding proteins to modulate gene expression. More importantly, a subset of circRNAs has be...
Identify the potential target of efferocytosis in knee osteoarthritis synovial tissue: a bioinformatics and machine learning-based study.
Frontiers in immunology
Feb 27, 2025
INTRODUCTION: Knee osteoarthritis (KOA) is a degenerative joint disease characterized by the progressive deterioration of cartilage and synovial inflammation. A critical mechanism in the pathogenesis of KOA is impaired efferocytosis in synovial tissu...
Identification of potential biomarkers for lung cancer using integrated bioinformatics and machine learning approaches.
PloS one
Feb 27, 2025
Lung cancer is one of the most common cancer and the leading cause of cancer-related death worldwide. Early detection of lung cancer can help reduce the death rate; therefore, the identification of potential biomarkers is crucial. Thus, this study ai...
Leveraging diverse cell-death patterns in diagnosis of sepsis by integrating bioinformatics and machine learning.
PeerJ
Feb 26, 2025
BACKGROUND: Sepsis is a life-threatening disease causing millions of deaths every year. It has been reported that programmed cell death (PCD) plays a critical role in the development and progression of sepsis, which has the potential to be a diagnosi...
Tisslet tissues-based learning estimation for transcriptomics.
BMC bioinformatics
Feb 25, 2025
In the context of multi-omics data analytics for various diseases, transcriptome-wide association studies leveraging genetically predicted gene expression hold promise for identifying novel regions linked to complex traits. However, existing methods ...
Identification of lipid metabolism related immune markers in atherosclerosis through machine learning and experimental analysis.
Frontiers in immunology
Feb 25, 2025
BACKGROUND: Atherosclerosis is a significant contributor to cardiovascular disease, and conventional diagnostic methods frequently fall short in the timely and accurate detection of early-stage atherosclerosis. Abnormal lipid metabolism plays a criti...
DeepTree-AAPred: Binary tree-based deep learning model for anti-angiogenic peptides prediction.
Journal of molecular graphics & modelling
Feb 24, 2025
Anti-angiogenic peptides (AAPs) show important potential in tumor therapy by limiting the growth and metastasis of tumor cells. Accurate prediction of AAPs is of very positive significance for the therapeutic efficacy of tumors. The high cost of wet ...
A novel coarsened graph learning method for scalable single-cell data analysis.
Computers in biology and medicine
Feb 24, 2025
The emergence of single-cell technologies, including flow and mass cytometry, as well as single-cell RNA sequencing, has revolutionized the study of cellular heterogeneity, generating vast datasets rich in biological insights. Despite the effectivene...
Identification of Biomarkers for Response to Interferon in Chronic Hepatitis B Based on Bioinformatics Analysis and Machine Learning.
Viral immunology
Feb 24, 2025
Interferon (IFN) is a pivotal agent against hepatitis B virus (HBV) in clinic, but there is a lack of accurate biomarkers to predict the response to IFN therapy in patients with chronic hepatitis B (CHB). Our study aimed to investigate potential targ...
Atrial fibrillation risk model based on LASSO and SVM algorithms and immune infiltration of key mitochondrial energy metabolism genes.
Scientific reports
Feb 24, 2025
Atrial fibrillation (AF) is a predominant cardiac arrhythmia with unclear etiology. This study used bioinformatics and machine learning to explore the relationship between mitochondrial energy metabolism-related genes (MEMRGs) and immune infiltration...
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