AIMC Topic: Cytokines

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Integrating Multiomics Information in Deep Learning Architectures for Joint Actuarial Outcome Prediction in Non-Small Cell Lung Cancer Patients After Radiation Therapy.

International journal of radiation oncology, biology, physics Feb 1, 2021
PURPOSE: Novel actuarial deep learning neural network (ADNN) architectures are proposed for joint prediction of radiation therapy outcomes-radiation pneumonitis (RP) and local control (LC)-in stage III non-small cell lung cancer (NSCLC) patients. Unl...
Humans Cytokines Female Treatment Outcome Carcinoma, Non-Small-Cell Lung MicroRNAs Positron-Emission Tomography Aged Radiation Pneumonitis Male Middle Aged Deep Learning Lung Neoplasms
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Circulating Neutrophil Extracellular Traps Signature for Identifying Organ Involvement and Response to Glucocorticoid in Adult-Onset Still's Disease: A Machine Learning Study.

Frontiers in immunology Nov 9, 2020
Adult-onset Still's disease (AOSD) is an autoinflammatory disease with multisystem involvement. Early identification of patients with severe complications and those refractory to glucocorticoid is crucial to improve therapeutic strategy in AOSD. Exag...
Cytokines Prognosis Female Young Adult Adult Male Middle Aged Glucocorticoids Case-Control Studies Treatment Outcome Humans Extracellular Traps Support Vector Machine Cell-Free Nucleic Acids Still's Disease, Adult-Onset
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A peripheral inflammatory signature discriminates bipolar from unipolar depression: A machine learning approach.

Progress in neuro-psychopharmacology & biological psychiatry Oct 9, 2020
BACKGROUND: Mood disorders (major depressive disorder, MDD, and bipolar disorder, BD) are considered leading causes of life-long disability worldwide, where high rates of no response to treatment or relapse and delays in receiving a proper diagnosis ...
Diagnosis, Differential Depressive Disorder Adult Male Middle Aged Bipolar Disorder Inflammation Humans Machine Learning Cytokines Biomarkers Female
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Mechanism of baricitinib supports artificial intelligence-predicted testing in COVID-19 patients.

EMBO molecular medicine Jun 24, 2020
Baricitinib is an oral Janus kinase (JAK)1/JAK2 inhibitor approved for the treatment of rheumatoid arthritis (RA) that was independently predicted, using artificial intelligence (AI) algorithms, to be useful for COVID-19 infection via proposed anti-c...
Humans Artificial Intelligence Pandemics Adult Male Middle Aged Antiviral Agents Liver COVID-19 Cytokines Spheroids, Cellular Female SARS-CoV-2 Intracellular Signaling Peptides and Proteins Aged Betacoronavirus Pneumonia, Viral Azetidines Coronavirus Infections COVID-19 Drug Treatment Pyrazoles Protein Kinase Inhibitors Purines Protein Serine-Threonine Kinases Drug Repositioning Leukocytes Sulfonamides Drug Evaluation, Preclinical
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Serum markers improve current prediction of metastasis development in early-stage melanoma patients: a machine learning-based study.

Molecular oncology Jun 24, 2020
Metastasis development represents an important threat for melanoma patients, even when diagnosed at early stages and upon removal of the primary tumor. In this scenario, determination of prognostic biomarkers would be of great interest. Serum contain...
Neoplasm Staging Neoplasm Metastasis Biomarkers, Tumor Male Middle Aged Peptides ROC Curve Humans Machine Learning Cytokines Prognosis Female Melanoma
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A double-hit of stress and low-grade inflammation on functional brain network mediates posttraumatic stress symptoms.

Nature communications Apr 20, 2020
Growing evidence indicates a reciprocal relationship between low-grade systemic inflammation and stress exposure towards increased vulnerability to neuropsychiatric disorders, including posttraumatic stress disorder (PTSD). However, the neural correl...
Inflammation Magnetic Resonance Imaging Neural Pathways Nerve Net Female Young Adult Adult Male Stress Disorders, Post-Traumatic Neural Networks, Computer Cytokines Brain Republic of Korea Humans
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Anti-Inflammatory Activity of Sanjie Zhentong Capsule Assessed By Network Pharmacology Analysis of Adenomyosis Treatment.

Drug design, development and therapy Feb 20, 2020
BACKGROUND: Sanjie Zhentong capsule (SZC) offers excellent effect in treating adenomyosis (AM), which is a common and difficult gynecological disease in the clinic. However, the systematic analysis of its mechanism has not been carried out yet and fu...
Medicine, Chinese Traditional Lipopolysaccharides Cell Survival Drugs, Chinese Herbal Anti-Inflammatory Agents Capsules RAW 264.7 Cells Databases, Pharmaceutical Adenomyosis Cells, Cultured Neural Networks, Computer Cytokines Animals Mice Nitric Oxide
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A Machine-Learning Approach to Identify a Prognostic Cytokine Signature That Is Associated With Nivolumab Clearance in Patients With Advanced Melanoma.

Clinical pharmacology and therapeutics Dec 19, 2019
Lower clearance of immune checkpoint inhibitors is a predictor of improved overall survival (OS) in patients with advanced cancer. We investigated a novel approach using machine learning to identify a baseline composite cytokine signature via clearan...
Skin Neoplasms Antineoplastic Agents, Immunological Humans Nivolumab Metabolic Clearance Rate Machine Learning Cytokines Prognosis Melanoma
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Decoding rumination: A machine learning approach to a transdiagnostic sample of outpatients with anxiety, mood and psychotic disorders.

Journal of psychiatric research Dec 7, 2019
OBJECTIVE: To employ machine learning algorithms to examine patterns of rumination from RDoC perspective and to determine which variables predict high levels of maladaptive rumination across a transdiagnostic sample.
Cytokines Female Adult Male Middle Aged Humans Anxiety Disorders Mood Disorders Severity of Illness Index Social Class Models, Theoretical Adaptation, Psychological Support Vector Machine Rumination, Cognitive Psychotic Disorders
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A 21‑gene Support Vector Machine classifier and a 10‑gene risk score system constructed for patients with gastric cancer.

Molecular medicine reports Nov 21, 2019
Gastric cancer (GC) ranks fifth in terms of incidence and third in terms of tumor mortality worldwide. The present study was designed to construct a Support Vector Machine (SVM) classifier and risk score system for GC. The GSE62254 (training set) and...
Kaplan-Meier Estimate Angiopoietin-like Proteins A Kinase Anchor Proteins Angiopoietin-Like Protein 1 Gene Expression Profiling Risk Factors Humans Gene Regulatory Networks Databases, Genetic Aged Gene Expression Regulation, Neoplastic Cytokines Carrier Proteins Stomach Neoplasms Membrane Proteins Prognosis Nerve Tissue Proteins Male Support Vector Machine Female Neoplasm Recurrence, Local Middle Aged Tumor Suppressor Proteins
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