AIMC Topic: Cytokines

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A peripheral inflammatory signature discriminates bipolar from unipolar depression: A machine learning approach.

Progress in neuro-psychopharmacology & biological psychiatry Oct 9, 2020
BACKGROUND: Mood disorders (major depressive disorder, MDD, and bipolar disorder, BD) are considered leading causes of life-long disability worldwide, where high rates of no response to treatment or relapse and delays in receiving a proper diagnosis ...
Humans Male Middle Aged Bipolar Disorder Inflammation Diagnosis, Differential Depressive Disorder Machine Learning Cytokines Biomarkers Female Adult
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Mechanism of baricitinib supports artificial intelligence-predicted testing in COVID-19 patients.

EMBO molecular medicine Jun 24, 2020
Baricitinib is an oral Janus kinase (JAK)1/JAK2 inhibitor approved for the treatment of rheumatoid arthritis (RA) that was independently predicted, using artificial intelligence (AI) algorithms, to be useful for COVID-19 infection via proposed anti-c...
Intracellular Signaling Peptides and Proteins Betacoronavirus Pneumonia, Viral Azetidines COVID-19 Drug Treatment Male Cytokines Drug Repositioning Pyrazoles Humans Middle Aged Female Leukocytes Artificial Intelligence Protein Kinase Inhibitors SARS-CoV-2 Antiviral Agents Sulfonamides Purines Pandemics Aged Liver Drug Evaluation, Preclinical Spheroids, Cellular COVID-19 Adult Protein Serine-Threonine Kinases Coronavirus Infections
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Serum markers improve current prediction of metastasis development in early-stage melanoma patients: a machine learning-based study.

Molecular oncology Jun 24, 2020
Metastasis development represents an important threat for melanoma patients, even when diagnosed at early stages and upon removal of the primary tumor. In this scenario, determination of prognostic biomarkers would be of great interest. Serum contain...
Humans Biomarkers, Tumor Male Middle Aged Peptides ROC Curve Neoplasm Staging Machine Learning Cytokines Prognosis Female Melanoma Neoplasm Metastasis
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A double-hit of stress and low-grade inflammation on functional brain network mediates posttraumatic stress symptoms.

Nature communications Apr 20, 2020
Growing evidence indicates a reciprocal relationship between low-grade systemic inflammation and stress exposure towards increased vulnerability to neuropsychiatric disorders, including posttraumatic stress disorder (PTSD). However, the neural correl...
Inflammation Magnetic Resonance Imaging Neural Pathways Nerve Net Female Young Adult Adult Male Stress Disorders, Post-Traumatic Humans Neural Networks, Computer Cytokines Brain Republic of Korea
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Anti-Inflammatory Activity of Sanjie Zhentong Capsule Assessed By Network Pharmacology Analysis of Adenomyosis Treatment.

Drug design, development and therapy Feb 20, 2020
BACKGROUND: Sanjie Zhentong capsule (SZC) offers excellent effect in treating adenomyosis (AM), which is a common and difficult gynecological disease in the clinic. However, the systematic analysis of its mechanism has not been carried out yet and fu...
Anti-Inflammatory Agents Capsules RAW 264.7 Cells Databases, Pharmaceutical Adenomyosis Nitric Oxide Medicine, Chinese Traditional Lipopolysaccharides Neural Networks, Computer Cell Survival Cells, Cultured Drugs, Chinese Herbal Cytokines Animals Mice
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A Machine-Learning Approach to Identify a Prognostic Cytokine Signature That Is Associated With Nivolumab Clearance in Patients With Advanced Melanoma.

Clinical pharmacology and therapeutics Dec 19, 2019
Lower clearance of immune checkpoint inhibitors is a predictor of improved overall survival (OS) in patients with advanced cancer. We investigated a novel approach using machine learning to identify a baseline composite cytokine signature via clearan...
Humans Machine Learning Cytokines Antineoplastic Agents, Immunological Prognosis Nivolumab Melanoma Metabolic Clearance Rate Skin Neoplasms
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Decoding rumination: A machine learning approach to a transdiagnostic sample of outpatients with anxiety, mood and psychotic disorders.

Journal of psychiatric research Dec 7, 2019
OBJECTIVE: To employ machine learning algorithms to examine patterns of rumination from RDoC perspective and to determine which variables predict high levels of maladaptive rumination across a transdiagnostic sample.
Adaptation, Psychological Rumination, Cognitive Humans Models, Theoretical Cytokines Support Vector Machine Female Psychotic Disorders Mood Disorders Adult Social Class Male Middle Aged Anxiety Disorders Severity of Illness Index
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A 21‑gene Support Vector Machine classifier and a 10‑gene risk score system constructed for patients with gastric cancer.

Molecular medicine reports Nov 21, 2019
Gastric cancer (GC) ranks fifth in terms of incidence and third in terms of tumor mortality worldwide. The present study was designed to construct a Support Vector Machine (SVM) classifier and risk score system for GC. The GSE62254 (training set) and...
Nerve Tissue Proteins Cytokines Neoplasm Recurrence, Local Prognosis Tumor Suppressor Proteins Humans Female A Kinase Anchor Proteins Kaplan-Meier Estimate Gene Expression Regulation, Neoplastic Risk Factors Stomach Neoplasms Angiopoietin-Like Protein 1 Membrane Proteins Aged Angiopoietin-like Proteins Male Support Vector Machine Middle Aged Databases, Genetic Gene Expression Profiling Carrier Proteins Gene Regulatory Networks
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The FluPRINT dataset, a multidimensional analysis of the influenza vaccine imprint on the immune system.

Scientific data Oct 21, 2019
Machine learning has the potential to identify novel biological factors underlying successful antibody responses to influenza vaccines. The first attempts have revealed a high level of complexity in establishing influenza immunity, and many different...
Humans Immunogenicity, Vaccine Adolescent Machine Learning Immune System Child, Preschool Young Adult Cytokines Antibody Formation Adult Child Female Hemagglutination Inhibition Tests Male Immunophenotyping Aged Middle Aged Influenza Vaccines Aged, 80 and over Infant
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Zoster patients on earth and astronauts in space share similar immunologic profiles.

Life sciences in space research Oct 14, 2019
BACKGROUND: On long-duration spaceflight, most astronauts experience persistent immune dysregulation and the reactivation of latent herpesviruses, including varicella zoster virus (VZV). To understand the clinical risk of these perturbations to astro...
Saliva Astronauts T-Lymphocytes Herpes Zoster Humans Male Herpesvirus 3, Human Middle Aged Cytokines Lymphocyte Activation Female DNA, Viral Aged Adult
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