AIMC Topic: Disease Models, Animal
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Fully automated, deep learning segmentation of oxygen-induced retinopathy images.
JCI insight
Dec 21, 2017
Oxygen-induced retinopathy (OIR) is a widely used model to study ischemia-driven neovascularization (NV) in the retina and to serve in proof-of-concept studies in evaluating antiangiogenic drugs for ocular, as well as nonocular, diseases. The primary...
Gastro-protective effect of edible plant Artemisia argyi in ethanol-induced rats via normalizing inflammatory responses and oxidative stress.
Journal of ethnopharmacology
Dec 20, 2017
PHARMACOLOGICAL RELEVANCE: Artemisia argyi, a kind of ethnic drug, has a long-term use on gastric diseases and syndromes.
Gastric Mucosa
Plant Extracts
Stomach Ulcer
Rats, Wistar
Disease Models, Animal
Malondialdehyde
Macrophages
RAW 264.7 Cells
Animals
Superoxide Dismutase
Anti-Inflammatory Agents
Oxidative Stress
Free Radicals
Ethanol
Artemisia
Mice
Cytoprotection
Plants, Medicinal
Antioxidants
Phytotherapy
Inflammation Mediators
Anti-Ulcer Agents
Effects of docosahexaenoic acid on locomotor activity in ethanol-treated HIV-1 transgenic rats.
Journal of neurovirology
Dec 19, 2017
Binge drinking affects the onset and progression of human immunodeficiency virus (HIV)-associated neurological disorders. The HIV-1 transgenic (HIV-1Tg) rat was created with a gag- and pol-deleted HIV-1 viral genome to mimic HIV-infected patients rec...
Modeling spike-wave discharges by a complex network of neuronal oscillators.
Neural networks : the official journal of the International Neural Network Society
Dec 13, 2017
PURPOSE: The organization of neural networks and the mechanisms, which generate the highly stereotypical for absence epilepsy spike-wave discharges (SWDs) is heavily debated. Here we describe such a model which can both reproduce the characteristics ...
Oleanolic acid protects against pathogenesis of atherosclerosis, possibly via FXR-mediated angiotensin (Ang)-(1-7) upregulation.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Dec 8, 2017
Atherosclerosis, the leading cause of cardiovascular diseases in the world, is a chronic inflammatory disorder characterized by the dysfunction of arteries. Oleanolic acid (OA) is a bioactive nature product which exists in various plants and herbs. P...
A Machine Learning Approach to Automated Gait Analysis for the Noldus Catwalk System.
IEEE transactions on bio-medical engineering
Aug 24, 2017
OBJECTIVE: Gait analysis of animal disease models can provide valuable insights into in vivo compound effects and thus help in preclinical drug development. The purpose of this paper is to establish a computational gait analysis approach for the Nold...
Anatomic and non-anatomic anterior cruciate ligament posterolateral bundle augmentation affects graft function.
Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA
Jul 29, 2017
PURPOSE: The purpose of this study is to compare knee laxity and graft function (tissue force) between anatomic and non-anatomic posterolateral (PL) bundle augmentation.
Robot-Applied Resistance Augments the Effects of Body Weight-Supported Treadmill Training on Stepping and Synaptic Plasticity in a Rodent Model of Spinal Cord Injury.
Neurorehabilitation and neural repair
Jul 25, 2017
BACKGROUND: The application of resistive forces has been used during body weight-supported treadmill training (BWSTT) to improve walking function after spinal cord injury (SCI). Whether this form of training actually augments the effects of BWSTT is ...
Feasibility study on robot-assisted retinal vascular bypass surgery in an ex vivo porcine model.
Acta ophthalmologica
Jun 9, 2017
PURPOSE: To describe a new robot-assisted surgical system for retinal vascular bypass surgery (RVBS) and to compare the success rate with freehand RVBS.
Automated analysis of brain activity for seizure detection in zebrafish models of epilepsy.
Journal of neuroscience methods
Jun 1, 2017
BACKGROUND: Epilepsy is a chronic neurological condition, with over 30% of cases unresponsive to treatment. Zebrafish larvae show great potential to serve as an animal model of epilepsy in drug discovery. Thanks to their high fecundity and relatively...
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