AIMC Topic: Disease Progression

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Multi-classifier prediction of knee osteoarthritis progression from incomplete imbalanced longitudinal data.

Scientific reports
Conventional inclusion criteria used in osteoarthritis clinical trials are not very effective in selecting patients who would benefit from a therapy being tested. Typically majority of selected patients show no or limited disease progression during a...

Predicting conversion to wet age-related macular degeneration using deep learning.

Nature medicine
Progression to exudative 'wet' age-related macular degeneration (exAMD) is a major cause of visual deterioration. In patients diagnosed with exAMD in one eye, we introduce an artificial intelligence (AI) system to predict progression to exAMD in the ...

The usefulness of the Deep Learning method of variational autoencoder to reduce measurement noise in glaucomatous visual fields.

Scientific reports
The aim of the study was to investigate the usefulness of processing visual field (VF) using a variational autoencoder (VAE). The training data consisted of 82,433 VFs from 16,836 eyes. Testing dataset 1 consisted of test-retest VFs from 104 eyes wit...

DeepSeg: deep neural network framework for automatic brain tumor segmentation using magnetic resonance FLAIR images.

International journal of computer assisted radiology and surgery
PURPOSE: Gliomas are the most common and aggressive type of brain tumors due to their infiltrative nature and rapid progression. The process of distinguishing tumor boundaries from healthy cells is still a challenging task in the clinical routine. Fl...

A CNN-aided method to predict glaucoma progression using DARC (Detection of Apoptosing Retinal Cells).

Expert review of molecular diagnostics
BACKGROUND: A key objective in glaucoma is to identify those at risk of rapid progression and blindness. Recently, a novel first-in-man method for visualising apoptotic retinal cells called DARC (Detection-of-Apoptosing-Retinal-Cells) was reported. T...

Gait-Based Machine Learning for Classifying Patients with Different Types of Mild Cognitive Impairment.

Journal of medical systems
Mild cognitive impairment (MCI) may be caused by Alzheimer's disease, Parkinson's disease (PD), cerebrovascular accident, nutritional or metabolic disorders, or mental disorders. It is important to determine the cause and treatment of dementia as ear...

Determinants of Cone and Rod Functions in Geographic Atrophy: AI-Based Structure-Function Correlation.

American journal of ophthalmology
PURPOSE: To investigate the association between retinal microstructure and cone and rod function in geographic atrophy (GA) secondary to age-related macular degeneration (AMD) by using artificial intelligence (AI) algorithms.