AIMC Topic: Dose-Response Relationship, Drug

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Novel indolizine derivatives lowers blood glucose levels in streptozotocin-induced diabetic rats: A histopathological approach.

Pharmacological reports : PR Nov 28, 2018
BACKGROUND: Diabetes mellitus is a deadly disorder in human which induce chronic complications. The streptozotocin (STZ)-induced diabetes in rat is the most common animal model of human diabetes. The present study investigated the effects of novel in...
Rats Hypoglycemic Agents Dose-Response Relationship, Drug Diabetes Mellitus, Experimental Administration, Oral Female Animals Male Blood Glucose Rats, Wistar Inhibitory Concentration 50 Humans Indolizines Streptozocin
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Ultrasound-Guided Continuous Thoracic Erector Spinae Plane Block Within an Enhanced Recovery Program Is Associated with Decreased Opioid Consumption and Improved Patient Postoperative Rehabilitation After Open Cardiac Surgery-A Patient-Matched, Controlled Before-and-After Study.

Journal of cardiothoracic and vascular anesthesia Nov 19, 2018
OBJECTIVES: Open cardiac surgery may cause severe postoperative pain. The authors hypothesized that patients receiving a bundle of care using continuous erector spinae plane blocks (ESPB) would have decreased perioperative opioid consumption and impr...
Male Middle Aged Adolescent Ultrasonography Cardiac Surgical Procedures Nerve Block Follow-Up Studies Pain Management Dose-Response Relationship, Drug Drug Administration Schedule Prospective Studies Postoperative Care Enhanced Recovery After Surgery Humans Female Pain, Postoperative Thoracic Nerves Aged Analgesics, Opioid Young Adult Adult
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The antibacterial activity of rhamnolipid biosurfactant is pH dependent.

Food research international (Ottawa, Ont.) Sep 6, 2018
Rhamnolipid (RL) biosurfactants have been studied as agents to control the growth of food pathogens however, to be successful applied as antimicrobial agent in food, is important to determine the effect of environmental conditions on RL activity. Onc...
Hydrophobic and Hydrophilic Interactions Gram-Positive Bacteria Glycolipids Food Contamination Dose-Response Relationship, Drug Anti-Bacterial Agents Food Microbiology Microbial Sensitivity Tests Surface-Active Agents Hydrogen-Ion Concentration
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RASPELD to Perform High-End Screening in an Academic Environment toward the Development of Cancer Therapeutics.

ChemMedChem Aug 23, 2018
The identification of compounds for dissecting biological functions and the development of novel drug molecules are central tasks that often require screening campaigns. However, the required architecture is cost- and time-intensive. Herein we descri...
Humans Antineoplastic Agents Protein Binding Dose-Response Relationship, Drug Robotics Protein Kinase Inhibitors NF-E2-Related Factor 2 Small Molecule Libraries Education, Graduate Kelch-Like ECH-Associated Protein 1 Mutation Drug Evaluation, Preclinical Biological Assay Ligands ErbB Receptors
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The antifibrotic effect of isolate tagitinin C from tithonia diversifolia (Hemsley) A. Gray on keloid fibroblast cell.

The Pan African medical journal Aug 8, 2018
INTRODUCTION: Keloids characterized by fibroblast hyperproliferation and depositions of collagen which similar to cancer cells. Tagitinin C is a class of sesquiterpene lactones (SLS) was isolated from the leaves of the moon flower (Hemsley) A. Gray....
Collagen Fibroblasts Humans Dose-Response Relationship, Drug Cells, Cultured Asteraceae Cell Survival Time Factors Keloid Sesquiterpenes Enzyme-Linked Immunosorbent Assay Mitomycin Inhibitory Concentration 50 Cell Proliferation
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Artificial intelligence outperforms experienced nephrologists to assess dry weight in pediatric patients on chronic hemodialysis.

Pediatric nephrology (Berlin, Germany) Jul 9, 2018
BACKGROUND: Dry weight is the lowest weight patients on hemodialysis can tolerate; correct dry weight estimation is necessary to minimize morbi-mortality, but is difficult to achieve. Here, we used artificial intelligence to improve the accuracy of d...
Body Weight Humans Adolescent Dose-Response Relationship, Drug Neural Networks, Computer Child Blood Pressure Hypertension Antihypertensive Agents Blood Pressure Determination Kidney Failure, Chronic Body Mass Index Feasibility Studies Female Male Renal Dialysis Body Fluids Nephrologists Blood Volume Decision Making, Computer-Assisted
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Optimal dynamic regimens with artificial intelligence: The case of temozolomide.

PloS one Jun 26, 2018
We determine an optimal protocol for temozolomide using population variability and dynamic optimization techniques inspired by artificial intelligence. We use a Pharmacokinetics/Pharmacodynamics (PK/PD) model based on Faivre and coauthors (Faivre, et...
Dose-Response Relationship, Drug Models, Biological Monte Carlo Method Temozolomide Antineoplastic Agents, Alkylating Artificial Intelligence Algorithms Neoplasms Treatment Outcome Humans
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Antiproliferative and anti-apoptotic effect of astaxanthin in an oxygen-induced retinopathy mouse model.

Canadian journal of ophthalmology. Journal canadien d'ophtalmologie Apr 11, 2018
OBJECTIVE: To evaluate the impact of intravitreal (IV) and intraperitoneal (IP) astaxanthin (AST) injections on neovascular development (ND), retinal morphology, and apoptotic activity in a C57BL/6J mouse model with hyperoxia-induced retinopathy (HIR...
Retina Xanthophylls Animals Mice, Inbred BALB C Random Allocation Hyperoxia Mice Apoptosis In Situ Nick-End Labeling Retinal Diseases Cell Proliferation Dose-Response Relationship, Drug Intravitreal Injections Animals, Newborn Disease Models, Animal Fibrinolytic Agents Microscopy, Electron Oxygen
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Noninvasive detection of macrophage activation with single-cell resolution through machine learning.

Proceedings of the National Academy of Sciences of the United States of America Mar 6, 2018
We present a method enabling the noninvasive study of minute cellular changes in response to stimuli, based on the acquisition of multiple parameters through label-free microscopy. The retrieved parameters are related to different attributes of the c...
Image Processing, Computer-Assisted Mice Progesterone Spectrum Analysis, Raman Lipopolysaccharides Machine Learning Animals Single-Cell Analysis Dose-Response Relationship, Drug Microscopy, Fluorescence Models, Biological RAW 264.7 Cells Macrophage Activation
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Gene-Specific Variant Classifier (DPYD-Varifier) to Identify Deleterious Alleles of Dihydropyrimidine Dehydrogenase.

Clinical pharmacology and therapeutics Feb 2, 2018
Deleterious variants in dihydropyrimidine dehydrogenase (DPD, DPYD gene) can be highly predictive of clinical toxicity to the widely prescribed chemotherapeutic 5-fluorouracil (5-FU). However, there are very limited data pertaining to the functional ...
Gene Frequency Protein Conformation Antimetabolites, Antineoplastic Mutation, Missense Dihydrouracil Dehydrogenase (NADP) Models, Molecular Fluorouracil Inhibitory Concentration 50 HCT116 Cells HEK293 Cells Pharmacogenomic Testing Pharmacogenomic Variants Humans Machine Learning Computer Simulation Risk Assessment Pharmacogenetics Genotype Dose-Response Relationship, Drug Cell Survival Predictive Value of Tests Structure-Activity Relationship
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