AIMC Topic: Male

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Size-Specific Predictors for Malignancy Risk in Follicular Thyroid Neoplasms: Machine Learning Analysis.

JMIR cancer
BACKGROUND: Surgeons often face challenges in distinguishing between benign and malignant follicular thyroid neoplasms (FTNs), particularly small tumors, until diagnostic surgery is performed.

SPP1 promotes malignant characteristics and drug resistance in hepatocellular carcinoma by activating fatty acid metabolic pathway.

Functional & integrative genomics
Hepatocellular carcinoma (HCC) progression and prognosis are influenced by various molecular markers. This study aimed to identify the hub gene associated with HCC clinical characteristics and its role in HCC progression. Differentially expressed gen...

Urine-based Raman markers for prostate cancer diagnosis: A machine learning approach using fingerprint and lipid spectral region.

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy
This study investigates the potential of Raman spectroscopy in distinguishing between healthy individuals and prostate cancer patients using urine samples. The Boruta algorithm was applied to Raman spectral data in two distinct wavenumber regions: 80...

Diagnostic immune-related markers for diabetic kidney disease: a bioinformatics and machine learning approach.

Renal failure
OBJECTIVE: Diabetic kidney disease (DKD) is a leading cause of chronic kidney disease, with chronic inflammation driving its progression. This study aimed to identify immune-related diagnostic biomarkers for DKD and explore their association with imm...

A noninvasive and highly efficient epigenetic predictive model for efficacy of the GOLP regimen in patients with intrahepatic cholangiocarcinoma.

Cancer letters
The GOLP regimen (Gemcitabine, Oxaliplatin, Lenvatinib and anti-PD1 antibody) has been a promising first-line treatment for advanced intrahepatic cholangiocarcinoma (iCCA). A noninvasive tool to predict the response to GOLP regimen is needed for clin...

Prediction of possible new drug binding site for ATP-sensitive potassium channel inhibition: bupropion's modulation of hippocampal CA1 neuron excitability.

Neuroreport
OBJECTIVE: Bupropion, a norepinephrine-dopamine reuptake inhibitor, is widely used as an antidepressant and smoking cessation aid. At high doses, it also inhibits pancreatic β-cell ATP-sensitive potassium (KATP) channels, inducing insulin secretion. ...

Rank labels scaffold social cognitive maps in the hippocampal-entorhinal system.

NeuroImage
How do humans construct mental representations of social hierarchies in the absence of direct interpersonal interactions? In many real-world contexts, humans rely on symbolic rank labels-such as titles or performance ratings-to navigate social hierar...

MAMSI: Integration of Multiassay Liquid Chromatography-Mass Spectrometry Metabolomics Data Using Multiview Machine Learning.

Analytical chemistry
Liquid chromatography-mass spectrometry (LC-MS) is a commonly used analytical technique in untargeted metabolomics. However, the diverse chemical and physical properties of metabolites often require the use of several different analytical assays for ...

Feasibility study of using GPT for history-taking training in medical education: a randomized clinical trial.

BMC medical education
BACKGROUNDS: Traditional methods of teaching history-taking in medical education are limited by scalability and resource intensity. This study aims to assess the effectiveness of simulated patient interactions based on a custom-designed Generative Pr...