BACKGROUNDS: The etiology of depression involves chronic stress, a recognized determinant of onset and severity. This study adopts a translational approach, utilizing a mouse model and a clinical cohort to explore the relationship between chronic str...
Systemic lupus erythematosus (SLE), a multifaceted autoimmune disorder, has lupus nephritis (LN) as one of its grave complications and is strongly associated with dyslipidemia. This investigation sought to delineate renal-specific lipid metabolism-re...
Journal of the American Society for Mass Spectrometry
Sep 3, 2025
Lung cancer metastasis, the leading cause of patient mortality, is driven by circulating tumor cells (CTCs), which act as direct mediators of metastatic spread. To elucidate the metabolic heterogeneity across lung cancer metastatic stages, a panorami...
BACKGROUND: Tumour suppressor genes, exemplified by TP53 (encoding the human p53), function as critical guardians against tumourigenesis. Germline TP53-inactivating mutations underlie Li-Fraumeni syndrome, a hereditary cancer predisposition disorder ...
Journal of biochemical and molecular toxicology
Sep 1, 2025
Autism spectrum disorder (ASD) is a complex neurodevelopmental condition characterized by impaired social interaction, communication deficits, and repetitive behaviors. However, the underlying molecular mechanisms remain elusive. This study aims to i...
Ecotoxicology and environmental safety
Sep 1, 2025
Microplastics are tiny plastic particles originating from both commercial product manufacturing and the degradation of larger plastic materials. These particles pose significant risks to environmental and animal health. A growing body of evidence hig...
Diabetic nephropathy (DN) is the main cause of end‑stage renal disease, with epithelial‑mesenchymal transition (EMT) serving a key role in its initiation and progression. Nevertheless, the precise mechanisms involved remain unidentified. The present ...
BACKGROUND: Diabetic nephropathy (DN), affecting 30%-40% of diabetic patients, is the leading cause of end-stage renal disease worldwide. This study aims to identify diagnostic biomarkers and explore potential gene-metabolite interactions in DN patho...
Metabolic dysfunction-associated steatotic liver disease (MASLD) is a spectrum of chronic pathologic conditions strongly associated with metabolic syndrome and affects approximately 38 % of the global population. Untreated MASLD may progress to metab...
Autism spectrum disorder (ASD) is characterized by deficits in social communication and repetitive behaviors/restricted interests that may be diagnosed as early as 2 years of age. This suggests that the pathology underlying the disorder is present du...
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