AIMC Topic: Mice
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Multi-task genomic prediction using gated residual variable selection neural networks.
BMC bioinformatics
Jul 7, 2025
BACKGROUND: The recent development of high-throughput sequencing techniques provide massive data that can be used in genome-wide prediction (GWP). Although GWP is effective on its own, the incorporation of traditional polygenic pedigree information i...
Nuclear morphometrics coupled with machine learning identifies dynamic states of senescence across age.
Nature communications
Jul 7, 2025
Cellular senescence is an irreversible state of cell cycle arrest with a complex role in tissue repair, aging, and disease. However, inconsistencies in identifying cellular senescence have led to varying conclusions about their functional significanc...
Early transcriptional responses reveal cell type-specific vulnerability and neuroprotective mechanisms in the neonatal ischemic hippocampus.
Acta neuropathologica communications
Jul 5, 2025
Neonatal hypoxic-ischemic (H-I) brain injury, a leading cause of neurodevelopmental disabilities, severely affects the metabolically active and neurogenic hippocampus. To investigate its acute effects and identify drug targets for early therapeutic w...
Targeting PFKFB3 to restore glucose metabolism in acute pancreatitis via nanovesicle delivery.
Molecular medicine (Cambridge, Mass.)
Jul 5, 2025
BACKGROUND: Acute pancreatitis (AP) is a severe inflammatory disease frequently accompanied by disturbances in glucose metabolism, which further complicate the disease prognosis. This study aims to explore the role of PFKFB3, a key glycolytic enzyme,...
A modular fluorescent camera unit for wound imaging.
Communications biology
Jul 5, 2025
Advanced imaging tools are revolutionizing the diagnosis, treatment, and monitoring of medical conditions, offering unprecedented insights into live cell behavior and biophysical markers. We introduce a modular, hand-held fluorescent microscope featu...
Liposome-encapsulated AICAR hydrogel regulates macrophage metabolic reprogramming via SIK1 activation to alleviate osteoarthritis.
Journal of nanobiotechnology
Jul 5, 2025
BACKGROUND: Osteoarthritis (OA), the most prevalent joint disorder, is characterized by a complex etiology and a lack of safe and effective therapeutic interventions. Emerging evidence suggests that immune cell dysregulation plays a pivotal role in t...
Diff-SE: A Diffusion-Augmented Contrastive Learning Framework for Super-Enhancer Prediction.
Journal of chemical information and modeling
Jul 4, 2025
Super-enhancers (SEs) are cis-regulatory elements that play crucial roles in gene expression and are implicated in diseases such as cancer and Alzheimer's. Traditional identification methods rely on ChIP-seq experiments, which are costly and time-con...
Uncovering key markers and therapeutic targets for renal fibrosis in diabetic kidney disease through bulk and single-cell RNA sequencing.
Journal of translational medicine
Jul 4, 2025
BACKGROUND: Diabetic kidney disease (DKD) is the major cause of chronic kidney failure, with tubulointerstitial fibrosis playing a crucial role in disease development. Identifying fibrosis-related genes is crucial for improving diagnosis and developi...
3BTRON: A Blood-Brain Barrier Recognition Network.
Communications biology
Jul 4, 2025
The blood-brain barrier (BBB) plays a crucial role in maintaining brain homeostasis. During ageing, the BBB undergoes structural alterations. Electron microscopy (EM) is the gold standard for studying the structural alterations of the brain vasculatu...
Divide-and-conquer strategy with engineered ossification center organoids for rapid bone healing through developmental cell recruitment.
Nature communications
Jul 4, 2025
Current approaches for bone repair predominantly target localized delivery of growth factors that are aimed at the coupling of angiogenesis and osteogenesis. However, delayed revascularization and regeneration of critical-sized bone defects are still...
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