AIMC Topic: Mice

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Increasing neural network robustness improves match to macaque V1 eigenspectrum, spatial frequency preference and predictivity.

PLoS computational biology Jan 7, 2022
Task-optimized convolutional neural networks (CNNs) show striking similarities to the ventral visual stream. However, human-imperceptible image perturbations can cause a CNN to make incorrect predictions. Here we provide insight into this brittleness...
Humans Computational Biology Models, Neurological Neurons Macaca fascicularis Primary Visual Cortex Neural Networks, Computer Algorithms Animals Mice
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Novel in Vivo and in Vitro Pharmacokinetic/Pharmacodynamic-Based Human Starting Dose Selection for Glofitamab.

Journal of pharmaceutical sciences Dec 22, 2021
We present a novel approach for first-in-human (FIH) dose selection of the CD20xCD3 bispecific antibody, glofitamab, based on pharmacokinetic/pharmacodynamic (PKPD) assessment in cynomolgus monkeys to select a high, safe starting dose, with cytokine ...
Mice Humans Antibodies, Bispecific Cytokines Lymphoma, B-Cell Interleukin-6 Macaca fascicularis Animals
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Structural, functional and molecular pathogenesis of pelvic organ prolapse in patient and deficient mice.

Aging Dec 19, 2021
Pelvic organ prolapse is a worldwide health problem to elderly women. Understanding its pathogenesis and an ideal animal model are crucial to developing promising treatments. The present study aimed to investigate new clinical significance and detail...
Humans Mice, Knockout Collagen Gene Ontology Pelvic Organ Prolapse Middle Aged Amino Acid Oxidoreductases Mice Disease Models, Animal Mice, Inbred C57BL Female Aged Aged, 80 and over Animals
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Wet-dry-wet drug screen leads to the synthesis of TS1, a novel compound reversing lung fibrosis through inhibition of myofibroblast differentiation.

Cell death & disease Dec 17, 2021
Therapies halting the progression of fibrosis are ineffective and limited. Activated myofibroblasts are emerging as important targets in the progression of fibrotic diseases. Previously, we performed a high-throughput screen on lung fibroblasts and s...
High-Throughput Screening Assays Drug Screening Assays, Antitumor Cell Differentiation Lung Diseases Transfection Mice Idiopathic Pulmonary Fibrosis Bleomycin Myofibroblasts Machine Learning Animals Drug Discovery Humans
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Integrated Multiomics Analysis Identifies a Novel Biomarker Associated with Prognosis in Intracerebral Hemorrhage.

Oxidative medicine and cellular longevity Dec 14, 2021
Existing treatments for intracerebral hemorrhage (ICH) are unable to satisfactorily prevent development of secondary brain injury after ICH and multiple pathological mechanisms are involved in the development of the injury. In this study, we aimed to...
Mice, Inbred C57BL Male Humans Cerebral Hemorrhage Mice Biomarkers Interleukin-12 Proteome Inflammasomes Prognosis Collagenases Brain Injuries Sphingolipids Animals
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Profiling epigenetic age in single cells.

Nature aging Dec 9, 2021
DNA methylation dynamics emerged as a promising biomarker of mammalian aging, with multivariate machine learning models ('epigenetic clocks') enabling measurement of biological age in bulk tissue samples. However, intrinsically sparse and binarized m...
Mammals Biomarkers Mice Animals Epigenesis, Genetic Aging DNA Methylation Hepatocytes
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A Novel Feature Selection Method for Uncertain Features: An Application to the Prediction of Pro-/Anti-Longevity Genes.

IEEE/ACM transactions on computational biology and bioinformatics Dec 8, 2021
Understanding the ageing process is a very challenging problem for biologists. To help in this task, there has been a growing use of classification methods (from machine learning) to learn models that predict whether a gene influences the process of ...
Aging Protein Interaction Maps Mice Computational Biology Drosophila melanogaster Uncertainty Yeasts Genome, Human Humans Machine Learning Algorithms Animals
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Label-free multiplexed microtomography of endogenous subcellular dynamics using generalizable deep learning.

Nature cell biology Dec 7, 2021
Simultaneous imaging of various facets of intact biological systems across multiple spatiotemporal scales is a long-standing goal in biology and medicine, for which progress is hindered by limits of conventional imaging modalities. Here we propose us...
Cell Nucleus Actins Cell Membrane Optical Imaging Chlorocebus aethiops HeLa Cells 3T3 Cells HEK293 Cells COS Cells Lipid Droplets Refractometry Cell Nucleolus Subcellular Fractions Electron Microscope Tomography Humans Animals Deep Learning Imaging, Three-Dimensional Mice Mitochondria Cell Line, Tumor Single-Cell Analysis
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Systems biology and machine learning approaches identify drug targets in diabetic nephropathy.

Scientific reports Dec 6, 2021
Diabetic nephropathy (DN), the leading cause of end-stage renal disease, has become a massive global health burden. Despite considerable efforts, the underlying mechanisms have not yet been comprehensively understood. In this study, a systematic appr...
Humans Machine Learning Algorithms Mice, Inbred DBA Kidney Cortex Kidney Medulla Linear Models Chemistry, Pharmaceutical Microarray Analysis Oligonucleotide Array Sequence Analysis Computational Biology Systems Biology Epigenesis, Genetic Gene Expression Profiling MicroRNAs Support Vector Machine Signal Transduction Animals Gene Regulatory Networks Regression Analysis Cluster Analysis Male Mice Principal Component Analysis Global Health Diabetic Nephropathies Drug Design
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Biofilm inhibition in Candida albicans with biogenic hierarchical zinc-oxide nanoparticles.

Biomaterials advances Dec 3, 2021
The present study demonstrates lignin (L), fragments of lignin (FL), and oxidized fragmented lignin (OFL) as templates for the synthesis of zinc oxide nanoparticles (ZnO NPs) viz., lignin-ZnO (L-ZnO), hierarchical FL-ZnO, and OFL-ZnO NPs. The X-ray d...
Animals Biofilms Mice Lignin Nanoparticles Rats Candida albicans Zinc Oxide
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