AIMC Topic: Rats
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Metabolic changes in rat serum after administration of suberoylanilide hydroxamic acid and discriminated by SVM.
Human & experimental toxicology
Jan 13, 2017
Suberoylanilide hydroxamic acid (SAHA) exerts marked anticancer effects via promotion of apoptosis, cell cycle arrest, and prevention of oncogene expression. In this study, serum metabolomics and artificial intelligence recognition were used to inves...
Achyranthes bidentate saponins protect rat articular chondrocytes against interleukin-1β-induced inflammation and apoptosis in vitro.
The Kaohsiung journal of medical sciences
Dec 30, 2016
Achyranthes bidentate Blume (Niuxi) is often employed for treatment of arthritis in Traditional Chinese Medicine and possesses anti-inflammatory properties. Phytochemical and pharmacological studies proved the oleanane-type saponins to be the main bi...
Achyranthes
bcl-Associated Death Protein
bcl-X Protein
Cyclooxygenase 2
Cartilage, Articular
Matrix Metalloproteinase 3
Primary Cell Culture
Tumor Suppressor Protein p53
Gene Expression Regulation
Proliferating Cell Nuclear Antigen
Anti-Inflammatory Agents, Non-Steroidal
Animals
Signal Transduction
Plant Roots
Plant Extracts
Male
Interleukin-1beta
Rats
Rats, Sprague-Dawley
Matrix Metalloproteinase 9
Inflammation
NF-kappa B
Apoptosis
bcl-2-Associated X Protein
Caspase 3
Chondrocytes
Saponins
Simultaneous determination of imperatorin and its metabolite xanthotoxol in rat plasma and urine by LC-MS/MS and its application to pharmacokinetic studies.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences
Dec 28, 2016
An accurate, precise, selective, and sensitive liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS) method was developed for the simultaneous determination of imperatorin (IMP) and its metabolite, xanthotoxol (XAN), in rat plasma and ...
Objective detection of apoptosis in rat renal tissue sections using light microscopy and free image analysis software with subsequent machine learning: Detection of apoptosis in renal tissue.
Tissue & cell
Dec 28, 2016
OBJECTIVE: The current study proposes an automated machine learning approach for the quantification of cells in cell death pathways according to DNA fragmentation.
[Effect of the Chinese Herbal Medicinal Ingredients in Huoxiang Zhengqi Liquid on Alcohol Metabolism in Rats].
Fa yi xue za zhi
Dec 25, 2016
OBJECTIVES: To study the changes of alcohol content and pharmacokinetic parameter in rats after taking Huoxiang Zhengqi liquid.
Differential cytotoxicity and internalization of graphene family nanomaterials in myocardial cells.
Materials science & engineering. C, Materials for biological applications
Dec 23, 2016
Given the well-known physical properties of graphene oxide (GO), numerous applications for this novel nanomaterial have been recently envisioned to improve the performance of biomedical devices. However, the toxicological assessment of GO, which stro...
Interneuronal mechanisms of hippocampal theta oscillations in a full-scale model of the rodent CA1 circuit.
eLife
Dec 23, 2016
The hippocampal theta rhythm plays important roles in information processing; however, the mechanisms of its generation are not well understood. We developed a data-driven, supercomputer-based, full-scale (1:1) model of the rodent CA1 area and studie...
Simultaneous quantification of batrachotoxin and epibatidine in plasma by ultra-performance liquid chromatography/tandem mass spectrometry.
Legal medicine (Tokyo, Japan)
Dec 22, 2016
An ultra-performance liquid chromatography/tandem mass spectrometry (UPLC-MS/MS) method was developed and validated for the simultaneous quantification of batrachotoxin and epibatidine in plasma. Plasma samples were pretreated by liquid-liquid extrac...
COF-1-modified magnetic nanoparticles for highly selective and efficient solid-phase microextraction of paclitaxel.
Talanta
Dec 21, 2016
Novel covalent organic framework-1 modified magnetic nanoparticles (M-COF-1) were prepared for extraction of paclitaxel from rat plasma samples. Paclitaxel is an important anti-cancer drug in clinical chemotherapy. COF-1 was immobilized on the surfac...
Robot-assisted mechanical therapy attenuates stroke-induced limb skeletal muscle injury.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Nov 28, 2016
The efficacy and optimization of poststroke physical therapy paradigms is challenged in part by a lack of objective tools available to researchers for systematic preclinical testing. This work represents a maiden effort to develop a robot-assisted me...
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