AIMC Topic: Signal Transduction

Clear Filters Showing 191 to 200 of 300 articles

Network fingerprint: a knowledge-based characterization of biomedical networks.

Scientific reports Aug 26, 2015
It can be difficult for biomedical researchers to understand complex molecular networks due to their unfamiliarity with the mathematical concepts employed. To represent molecular networks with clear meanings and familiar forms for biomedical research...
Humans Algorithms Pattern Recognition, Automated Protein Interaction Mapping Signal Transduction Computer Simulation Models, Biological Knowledge Bases Animals Proteome
View on PubMed DOI

Classification of signaling proteins based on molecular star graph descriptors using Machine Learning models.

Journal of theoretical biology Aug 20, 2015
Signaling proteins are an important topic in drug development due to the increased importance of finding fast, accurate and cheap methods to evaluate new molecular targets involved in specific diseases. The complexity of the protein structure hinders...
Quantitative Structure-Activity Relationship Intracellular Signaling Peptides and Proteins Humans Machine Learning Signal Transduction Databases, Protein
View on PubMed DOI

Knowledge-Based Analysis for Detecting Key Signaling Events from Time-Series Phosphoproteomics Data.

PLoS computational biology Aug 7, 2015
Cell signaling underlies transcription/epigenetic control of a vast majority of cell-fate decisions. A key goal in cell signaling studies is to identify the set of kinases that underlie key signaling events. In a typical phosphoproteomics study, phos...
Proteomics Proteome Signal Transduction Humans Phosphoproteins Cell Line Cell Communication Knowledge Bases Databases, Protein Embryonic Stem Cells Cell Differentiation
View on PubMed DOI

Prediction of MicroRNA-Disease Associations Based on Social Network Analysis Methods.

BioMed research international Jul 26, 2015
MicroRNAs constitute an important class of noncoding, single-stranded, ~22 nucleotide long RNA molecules encoded by endogenous genes. They play an important role in regulating gene transcription and the regulation of normal development. MicroRNAs can...
MicroRNAs Pattern Recognition, Automated Social Networking Models, Genetic Signal Transduction Databases, Genetic Algorithms Humans Computer Simulation Machine Learning Genetic Predisposition to Disease
View on PubMed DOI

Installing a Local Copy of the Reactome Web Site and Knowledgebase.

Current protocols in bioinformatics Jun 19, 2015
The Reactome project builds, maintains, and publishes a knowledgebase of biological pathways. The information in the knowledgebase is gathered from the experts in the field, peer reviewed and edited by Reactome editorial staff, and then published to ...
Databases as Topic Signal Transduction Internet Knowledge Bases Software
View on PubMed DOI

TENET: topological feature-based target characterization in signalling networks.

Bioinformatics (Oxford, England) Jun 16, 2015
MOTIVATION: Target characterization for a biochemical network is a heuristic evaluation process that produces a characterization model that may aid in predicting the suitability of each molecule for drug targeting. These approaches are typically used...
Humans Software Protein Interaction Mapping Algorithms Signal Transduction Support Vector Machine
View on PubMed DOI

Effects of xenoestrogens in human M1 and M2 macrophage migration, cytokine release, and estrogen-related signaling pathways.

Environmental toxicology May 26, 2015
Bisphenol A (BPA), bis(2-ethylhexyl)phthalate (DEHP) and di(n-butyl)phthalate (DBP) are environmental estrogens that have been associated with a wide range of adverse health outcomes for which inflammation has also been hypothesized as a potentially ...
Benzhydryl Compounds Diethylhexyl Phthalate Cell Migration Assays, Macrophage Middle Aged Chemotaxis, Leukocyte Phenols Estradiol Interleukin-1beta Signal Transduction Inflammation Macrophages NF-kappa B Cell Movement Humans Cytokines Lipopolysaccharides Tumor Necrosis Factor-alpha Female Cells, Cultured
View on PubMed DOI

Bioinformatics approach reveals systematic mechanism underlying lung adenocarcinoma.

Tumori May 21, 2015
BACKGROUND: The purpose of this work was to explore the systematic molecular mechanism of lung adenocarcinoma and gain a deeper insight into it.
Collagen Type X Humans Receptor Cross-Talk Signal Transduction Adenocarcinoma Computational Biology Calcium Gene Ontology Gene Expression Regulation, Neoplastic Software Peroxisome Proliferator-Activated Receptors Adenocarcinoma of Lung Membrane Proteins Gene Expression Profiling Protein Array Analysis Lung Neoplasms
View on PubMed DOI

Entity linking for biomedical literature.

BMC medical informatics and decision making May 20, 2015
BACKGROUND: The Entity Linking (EL) task links entity mentions from an unstructured document to entities in a knowledge base. Although this problem is well-studied in news and social media, this problem has not received much attention in the life sci...
Signal Transduction Natural Language Processing Data Mining Medical Informatics Semantics
View on PubMed DOI

MIMP: predicting the impact of mutations on kinase-substrate phosphorylation.

Nature methods May 4, 2015
Protein phosphorylation is important in cellular pathways and altered in disease. We developed MIMP (http://mimp.baderlab.org/), a machine learning method to predict the impact of missense single-nucleotide variants (SNVs) on kinase-substrate interac...
Phosphorylation Amino Acid Sequence Substrate Specificity Mutation, Missense Phosphotransferases Software Polymorphism, Single Nucleotide Signal Transduction Artificial Intelligence
View on PubMed DOI
Popular Topics
Recent Journals