AIMC Topic: Signal Transduction

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Drug target identification using network analysis: Taking active components in Sini decoction as an example.

Scientific reports Apr 20, 2016
Identifying the molecular targets for the beneficial effects of active small-molecule compounds simultaneously is an important and currently unmet challenge. In this study, we firstly proposed network analysis by integrating data from network pharmac...
Humans Neural Networks, Computer Proteins Structure-Activity Relationship Metabolic Networks and Pathways Drugs, Chinese Herbal Myocytes, Cardiac Tumor Necrosis Factor-alpha Reproducibility of Results Cell Line, Tumor Signal Transduction Metabolomics
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G-Protein-Coupled Receptor 35 Mediates Human Saphenous Vein Vascular Smooth Muscle Cell Migration and Endothelial Cell Proliferation.

Journal of vascular research Apr 12, 2016
Vascular smooth muscle cell (VSMC) migration and proliferation is central to neointima formation in vein graft failure following coronary artery bypass. However, there are currently no pharmacological interventions that prevent vein graft failure thr...
Naphthols Purinones Saphenous Vein Muscle, Smooth, Vascular Humans Cell Movement Thiazolidines HEK293 Cells Dose-Response Relationship, Drug Time Factors Hydrazones Myocytes, Smooth Muscle Receptors, G-Protein-Coupled Cell Proliferation Thiourea Endothelial Cells rho-Associated Kinases Signal Transduction Actin Cytoskeleton rhoA GTP-Binding Protein Aminosalicylic Acids
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Network-Based Identification and Prioritization of Key Regulators of Coronary Artery Disease Loci.

Arteriosclerosis, thrombosis, and vascular biology Mar 10, 2016
OBJECTIVE: Recent genome-wide association studies of coronary artery disease (CAD) have revealed 58 genome-wide significant and 148 suggestive genetic loci. However, the molecular mechanisms through which they contribute to CAD and the clinical impli...
Genetic Loci Gene Expression Regulation Lumican Databases, Genetic Bayes Theorem Coronary Artery Disease STAT3 Transcription Factor Humans Mice Neural Networks, Computer Genomics Gene Expression Profiling Phenotype Genetic Predisposition to Disease Case-Control Studies Computer Simulation Computational Biology Genome-Wide Association Study Animals Signal Transduction Protein Interaction Maps Gene Regulatory Networks
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Network stratification analysis for identifying function-specific network layers.

Molecular bioSystems Feb 16, 2016
A major challenge of systems biology is to capture the rewiring of biological functions (e.g. signaling pathways) in a molecular network. To address this problem, we proposed a novel computational framework, namely network stratification analysis (Ne...
Humans Neural Networks, Computer Protein Interaction Maps Gene Regulatory Networks Computational Biology Gene Expression Regulation, Neoplastic Signal Transduction Algorithms Disease Progression Gene Expression Profiling Liver Neoplasms Carcinoma, Hepatocellular Cluster Analysis Models, Biological Gene Expression Regulation, Fungal Transcription, Genetic
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Detection of overlapping protein complexes in gene expression, phenotype and pathways of Saccharomyces cerevisiae using Prorank based Fuzzy algorithm.

Gene Jan 22, 2016
Proteins show their functional activity by interacting with other proteins and forms protein complexes since it is playing an important role in cellular organization and function. To understand the higher order protein organization, overlapping is an...
Gene Expression Regulation, Fungal Protein Interaction Mapping Multiprotein Complexes Cluster Analysis Databases, Protein Fungal Proteins Saccharomyces cerevisiae Algorithms Phenotype Computational Biology Signal Transduction Fuzzy Logic
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Learning a hierarchical representation of the yeast transcriptomic machinery using an autoencoder model.

BMC bioinformatics Jan 11, 2016
BACKGROUND: A living cell has a complex, hierarchically organized signaling system that encodes and assimilates diverse environmental and intracellular signals, and it further transmits signals that control cellular responses, including a tightly con...
Neural Networks, Computer Computer Simulation Gene Expression Profiling Systems Biology Models, Theoretical Signal Transduction Transcription Factors Saccharomyces cerevisiae Gene Expression Regulation, Fungal Saccharomyces cerevisiae Proteins
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Drug repositioning for non-small cell lung cancer by using machine learning algorithms and topological graph theory.

BMC bioinformatics Jan 11, 2016
BACKGROUND: Non-small cell lung cancer (NSCLC) is one of the leading causes of death globally, and research into NSCLC has been accumulating steadily over several years. Drug repositioning is the current trend in the pharmaceutical industry for ident...
Carcinoma, Non-Small-Cell Lung Neoplasm Proteins Drug Repositioning Microarray Analysis Antineoplastic Agents Lung Neoplasms Gene Expression Regulation, Neoplastic Signal Transduction Models, Theoretical Humans Machine Learning Algorithms Drug Discovery
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Hericium erinaceus Inhibits TNF-α-Induced Angiogenesis and ROS Generation through Suppression of MMP-9/NF-κB Signaling and Activation of Nrf2-Mediated Antioxidant Genes in Human EA.hy926 Endothelial Cells.

Oxidative medicine and cellular longevity Dec 28, 2015
Hericium erinaceus (HE) is an edible mushroom that has been shown to exhibit anticancer and anti-inflammatory activities. We investigated the antiangiogenic and antioxidant potentials of ethanol extracts of HE in human endothelial (EA.hy926) cells up...
NF-E2-Related Factor 2 Angiogenesis Inducing Agents Tumor Necrosis Factor-alpha Neovascularization, Pathologic Antioxidants Reactive Oxygen Species Humans Heme Oxygenase-1 NF-kappa B Inflammation Glutathione Anti-Inflammatory Agents Signal Transduction Basidiomycota Matrix Metalloproteinase 9 Angiogenesis Inhibitors Endothelial Cells Intercellular Adhesion Molecule-1
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Sensitive and versatile electrogenerated chemiluminescence biosensing platform for protein kinase based on Ru(bpy)3(2+) functionalized gold nanoparticles mediated signal transduction.

Analytica chimica acta Dec 17, 2015
A novel, sensitive and versatile electrogenerated chemiluminescence biosensing platform is developed for monitoring activity and inhibition of protein kinase based on Ru(bpy)3(2+) functionalized gold nanoparticles (Ru(bpy)3(2+)-AuNPs) mediated signal...
Metal Nanoparticles Sensitivity and Specificity Luminescence Biosensing Techniques Protein Kinases Signal Transduction Microscopy, Atomic Force Gold Ruthenium Compounds
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Modulatory role of garlicin in migration and invasion of intrahepatic cholangiocarcinoma via PI3K/AKT pathway.

International journal of clinical and experimental pathology Nov 1, 2015
Increasing evidences have indicated the role of garlicin in inhibiting the progression of various tumors including glioma, pulmonary carcinoma and pancreatic carcinoma, via mediating cell apoptosis or cell cycle. The regulatory effect and related mol...
Antineoplastic Agents, Phytogenic Phosphorylation Proto-Oncogene Proteins c-akt Bile Duct Neoplasms Disulfides Allyl Compounds Protein Kinase Inhibitors Cholangiocarcinoma Phosphatidylinositol 3-Kinase Phosphoinositide-3 Kinase Inhibitors Cell Proliferation Signal Transduction Cell Movement Neoplasm Invasiveness Dose-Response Relationship, Drug Humans Cell Line, Tumor
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