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Deep learning unlocks the true potential of organ donation after circulatory death with accurate prediction of time-to-death.

Scientific reports Apr 19, 2025
Increasing the number of organ donations after circulatory death (DCD) has been identified as one of the most important ways of addressing the ongoing organ shortage. While recent technological advances in organ transplantation have increased their s...
Middle Aged Deep Learning Time Factors Death Tissue and Organ Procurement Female Aged Adult Male Humans Neural Networks, Computer Intensive Care Units
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Prediction of early recurrence in primary central nervous system lymphoma based on multimodal MRI-based radiomics: A preliminary study.

European journal of radiology Apr 18, 2025
OBJECTIVES: To evaluate the role of multimodal magnetic resonance imaging radiomics features in predicting early recurrence of primary central nervous system lymphoma (PCNSL) and to investigate their correlation with patient prognosis.
Retrospective Studies Female Aged Adult Radiomics Humans Prognosis Multimodal Imaging Predictive Value of Tests Neoplasm Recurrence, Local Methotrexate Central Nervous System Neoplasms Male Middle Aged Lymphoma Magnetic Resonance Imaging
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ULK2 deficiency stratifies autophagy-driven molecular subtypes and exacerbates trophoblasts apoptosis in preeclampsia.

Placenta Apr 18, 2025
INTRODUCTION: Preeclampsia (PE), a placenta-originated hypertensive disorder of pregnancy, lacks targeted therapies despite its significant contribution to maternal and fetal morbidity. Emerging evidence implicates autophagy dysregulation in PE patho...
Trophoblasts Intracellular Signaling Peptides and Proteins Female Adult Animals Mice Apoptosis Protein Serine-Threonine Kinases Placenta Autophagy Pre-Eclampsia Humans Pregnancy
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From marker to markerless: Validating DeepLabCut for 2D sagittal plane gait analysis in adults and newly walking toddlers.

Journal of biomechanics Apr 18, 2025
The use of 3D marker-based motion analysis systems is considered the gold standard for tracking limb movements. However, these systems are expensive, limited to laboratory settings, and difficult to apply when studying paediatric populations. Therefo...
Infant Child, Preschool Walking Gait Video Recording Gait Analysis Young Adult Adult Biomechanical Phenomena Male Humans Software Female
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Artificial neural network model enhancing the accuracy of clinical evaluation for high-risk population of lymph node metastasis in non-intestinal type early gastric cancer: a multicenter real-world study in China.

International journal of surgery (London, England) Apr 18, 2025
BACKGROUND: Recent years have witnessed a proliferation of studies aimed at developing clinical models capable of predicting lymph node metastasis (LNM) in early gastric cancer (EGC), yet tools for prediction grounded in the Lauren classification rem...
Stomach Neoplasms Male Middle Aged Risk Assessment China Retrospective Studies Female Aged Adult Nomograms Lymphatic Metastasis Humans Neural Networks, Computer Prognosis
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Diagnostic MicroRNA Signatures to Support Classification of Pulmonary Hypertension.

Circulation. Genomic and precision medicine Apr 18, 2025
BACKGROUND: Patients with pulmonary hypertension (PH) are classified based on disease pathogenesis and hemodynamic drivers. Classification informs treatment. The heart failure biomarker NT-proBNP (N-terminal pro-B-type natriuretic peptide) is used to...
Retrospective Studies Female Aged Adult Male Humans Biomarkers Hypertension, Pulmonary Natriuretic Peptide, Brain Middle Aged MicroRNAs Peptide Fragments United Kingdom
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AI-assisted identification of disability patterns within identical EDSS grades.

Multiple sclerosis (Houndmills, Basingstoke, England) Apr 18, 2025
BACKGROUND: The Neurostatus-Expanded Disability Status Scale (EDSS) is the most frequently used measure of disability in multiple sclerosis (MS) trials. However, EDSS scores ⩾4.5 are mainly based on ambulation and may fail to capture relevant disabil...
Multiple Sclerosis, Chronic Progressive Humans Artificial Intelligence Machine Learning Female Adult Male Middle Aged Severity of Illness Index Disability Evaluation
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Integrating Machine Learning and Follow-Up Variables to Improve Early Detection of Hepatocellular Carcinoma in Tyrosinemia Type 1: A Multicenter Study.

International journal of molecular sciences Apr 18, 2025
Hepatocellular carcinoma (HCC) is a major complication of tyrosinemia type 1 (HT-1), an inborn error of metabolism affecting tyrosine catabolism. The risk of HCC is higher in late diagnoses despite treatment. Alpha-fetoprotein (AFP) is widely used to...
Alanine Transaminase Tyrosinemias Follow-Up Studies Early Detection of Cancer alpha-Fetoproteins Alkaline Phosphatase Male Middle Aged Infant Adolescent Child, Preschool Child Liver Neoplasms Carcinoma, Hepatocellular Longitudinal Studies Infant, Newborn Young Adult Adult Biomarkers, Tumor Humans Machine Learning Retrospective Studies Female
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Brain-Computer Interface-controlled Upper Limb Robotic System for Enhancing Daily Activities in Stroke Patients.

Journal of visualized experiments : JoVE Apr 18, 2025
This study introduces a Brain-Computer Interface (BCI)-controlled upper limb assistive robot for post-stroke rehabilitation. The system utilizes electroencephalogram (EEG) and electrooculogram (EOG) signals to help users assist upper limb function in...
Stroke Rehabilitation Humans Female Aged Electroencephalography Activities of Daily Living Brain-Computer Interfaces Upper Extremity Electrooculography Adult Male Middle Aged Robotics
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Knowledge and use, perceptions of benefits and limitations of artificial intelligence chatbots among Italian physiotherapy students: a cross-sectional national study.

BMC medical education Apr 18, 2025
BACKGROUND: Artificial Intelligence (AI) Chatbots (e.g., ChatGPT, Microsoft Bing, and Google Bard) can emulate human interaction and may support physiotherapy education. Despite growing interest, physiotherapy students' perspectives remain unexplored...
Humans Artificial Intelligence Female Young Adult Generative Artificial Intelligence Health Knowledge, Attitudes, Practice Italy Physical Therapy Specialty Students, Health Occupations Adult Cross-Sectional Studies Male Surveys and Questionnaires
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