AIMC Topic: Cell Proliferation

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Hypothesis-free deep survival learning applied to the tumour microenvironment in gastric cancer.

The journal of pathology. Clinical research Jun 27, 2020
The biological complexity reflected in histology images requires advanced approaches for unbiased prognostication. Machine learning and particularly deep learning methods are increasingly applied in the field of digital pathology. In this study, we p...
Tumor Microenvironment Biomarkers, Tumor Risk Assessment Deep Learning Time Factors Humans Risk Factors Stomach Neoplasms Immunohistochemistry Antigens, CD20 Ki-67 Antigen Tissue Array Analysis Antigens, Differentiation, Myelomonocytic CD8 Antigens Cell Proliferation Predictive Value of Tests Antigens, CD Neoplasm Staging Image Interpretation, Computer-Assisted
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Intelligent image-based deformation-assisted cell sorting with molecular specificity.

Nature methods May 25, 2020
Although label-free cell sorting is desirable for providing pristine cells for further analysis or use, current approaches lack molecular specificity and speed. Here, we combine real-time fluorescence and deformability cytometry with sorting based on...
Humans Neural Networks, Computer Flow Cytometry Sound Microfluidics Erythrocytes HL-60 Cells Animals Cell Proliferation Neutrophils Cell Line Cell Survival Cell Culture Techniques Drosophila Cell Size Erythrocyte Deformability Myeloid Cells
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An Automated Segmentation Pipeline for Intratumoural Regions in Animal Xenografts Using Machine Learning and Saturation Transfer MRI.

Scientific reports May 15, 2020
Saturation transfer MRI can be useful in the characterization of different tumour types. It is sensitive to tumour metabolism, microstructure, and microenvironment. This study aimed to use saturation transfer to differentiate between intratumoural re...
Automation Tumor Cells, Cultured Male Magnetic Resonance Imaging Humans Image Processing, Computer-Assisted Mice, Nude Machine Learning Mice Apoptosis Algorithms Cell Proliferation Female Prostatic Neoplasms Adenocarcinoma Animals Xenograft Model Antitumor Assays
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Tabu Search and Machine-Learning Classification of Benign and Malignant Proliferative Breast Lesions.

BioMed research international Feb 27, 2020
Breast cancer is the most diagnosed cancer among women around the world. The development of computer-aided diagnosis tools is essential to help pathologists to accurately interpret and discriminate between malignant and benign tumors. This paper prop...
Neoplasms Diagnosis, Computer-Assisted Cell Proliferation Breast Image Interpretation, Computer-Assisted Fibrocystic Breast Disease Humans Machine Learning Algorithms Female Breast Neoplasms
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Single-cell dispensing and 'real-time' cell classification using convolutional neural networks for higher efficiency in single-cell cloning.

Scientific reports Jan 27, 2020
Single-cell dispensing for automated cell isolation of individual cells has gained increased attention in the biopharmaceutical industry, mainly for production of clonal cell lines. Here, machine learning for classification of cell images is applied ...
Antibodies, Monoclonal Clone Cells Image Cytometry Recombinant Proteins Cell Proliferation Cell Survival CHO Cells Cricetulus Neural Networks, Computer Machine Learning Computer Simulation Animals
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Propofol affects the growth and metastasis of pancreatic cancer via ADAM8.

Pharmacological reports : PR Dec 20, 2019
BACKGROUND: Anesthesia is a major component of surgery and recently considered an important regulator of cell phenotypes. Here we aimed to investigate propofol, an anesthesia drug, in suppressing pancreatic cancer (PDAC), focusing on A disintegrin an...
Pancreatic Neoplasms Cell Proliferation MAP Kinase Signaling System Matrix Metalloproteinase 9 Humans Propofol Matrix Metalloproteinase 2 ADAM Proteins Cell Movement Animals Xenograft Model Antitumor Assays Mice, SCID Apoptosis Antineoplastic Agents Neoplasm Metastasis Neoplasm Invasiveness Cell Line, Tumor Membrane Proteins
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Efficient identification of novel anti-glioma lead compounds by machine learning models.

European journal of medicinal chemistry Dec 19, 2019
Glioblastoma multiforme (GBM) is the most devastating and widespread primary central nervous system tumor. Pharmacological treatment of this malignance is limited by the selective permeability of the blood-brain barrier (BBB) and relies on a single d...
Mice, Inbred C57BL Models, Statistical Xenograft Model Antitumor Assays Humans Tumor Cells, Cultured Machine Learning Nitrofurans Cell Proliferation Female Glioma Animals Male Apoptosis Antineoplastic Agents Mice
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Chestnut shells (Italian cultivar "Marrone di Roccadaspide" PGI): Antioxidant activity and chemical investigation with in depth LC-HRMS/MS rationalization of tannins.

Food research international (Ottawa, Ont.) Nov 20, 2019
In Italy a particularly valuable chestnut is "Marrone di Roccadaspide", a protected geographical indication (PGI) product, deriving from a Castanea sativa cultivar, typical of Salerno province in Campania region. As chestnut industrial processes yiel...
Evaluation Studies as Topic NF-kappa B Italy Nuts Triterpenes Plant Extracts Humans Hydrolyzable Tannins Cell Proliferation Antioxidants Proanthocyanidins Glucosides Reactive Oxygen Species Rationalization Tandem Mass Spectrometry Flavonoids Tannins Calibration Phenols Ellagic Acid Fagaceae
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Four transcription profile-based models identify novel prognostic signatures in oesophageal cancer.

Journal of cellular and molecular medicine Nov 19, 2019
Oesophageal cancer (ESCA) is a clinically challenging disease with poor prognosis and health-related quality of life. Here, we investigated the transcriptome of ESCA to identify high risk-related signatures. A total of 159 ESCA patients of The Cancer...
Cell Proliferation Apoptosis Esophageal Neoplasms Esophageal Squamous Cell Carcinoma Tumor Cells, Cultured Biomarkers, Tumor Male Middle Aged Transcriptome Gene Expression Regulation, Neoplastic Machine Learning Humans Algorithms Prognosis Female Survival Rate
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System-level responses to cisplatin in pro-apoptotic stages of breast cancer MCF-7 cell line.

Computational biology and chemistry Nov 2, 2019
Cisplatin ceases cell division and induces apoptosis in cancer cell lines. It is well established that cisplatin alters the expression of many genes involved in several cellular processes and pathways including transcription, p53 signaling pathway, a...
Gene Ontology Humans Software Antineoplastic Agents Apoptosis Female Protein Interaction Maps Neoplasm Proteins Breast Neoplasms Gene Regulatory Networks Drug Screening Assays, Antitumor Drug Discovery Gene Expression Regulation, Neoplastic MCF-7 Cells Cell Proliferation Cisplatin
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