AIMC Topic: Cell Survival

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Protective effect of Nelumbo nucifera extracts on beta amyloid protein induced apoptosis in PC12 cells, in vitro model of Alzheimer's disease.

Journal of food and drug analysis Mar 17, 2017
Alzheimer's disease (AD) is the most common cause of dementia in the elderly. β-Amyloid (Aβ) has been proposed to play a role in the pathogenesis of AD. Deposits of insoluble Aβ are found in the brains of patients with AD and are one of the pathologi...
Alzheimer Disease Protein Aggregates PC12 Cells Reactive Oxygen Species Animals Cell Survival Antioxidants Nelumbo Molecular Structure Plant Extracts Protein Aggregation, Pathological Amyloid beta-Peptides Rats Chromatography, High Pressure Liquid Apoptosis
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Design, preparation and characterization of pH-responsive prodrug micelles with hydrolyzable anhydride linkages for controlled drug delivery.

Journal of colloid and interface science Dec 31, 2016
We report a new prodrug micelle-based approach in which a model hydrophobic non-steroidal anti-inflammatory drug (NSAID), ibuprofen (Ibu), is tethered to amphiphilic methoxy polyethylene glycol-polypropylene fumarate (mPEG-PPF) diblock copolymer via ...
Surface Properties Ibuprofen Anhydrides Fumarates Hydrogen-Ion Concentration Cell Line Micelles Polyethylene Glycols Cell Survival Prodrugs Hydrolysis Drug Carriers HeLa Cells Humans Solubility Anti-Inflammatory Agents, Non-Steroidal Hydrophobic and Hydrophilic Interactions Animals Drug Liberation Rabbits Polypropylenes Nanoparticles
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Preparation of arginine-glycine-aspartic acid-modified biopolymeric nanoparticles containing epigalloccatechin-3-gallate for targeting vascular endothelial cells to inhibit corneal neovascularization.

International journal of nanomedicine Dec 30, 2016
Neovascularization (NV) of the cornea can disrupt visual function, causing ocular diseases, including blindness. Therefore, treatment of corneal NV has a high public health impact. Epigalloccatechin-3-gallate (EGCG), presenting antiangiogenesis effec...
Integrin alphaVbeta3 Corneal Neovascularization Eye Burns Ophthalmic Solutions Hyaluronic Acid Catechin Molecular Targeted Therapy Oligopeptides Humans Animals Nanoparticles Angiogenesis Inhibitors Disease Models, Animal Mice, Inbred C57BL Cell Survival Burns, Chemical Human Umbilical Vein Endothelial Cells
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Anticancer and anti-inflammatory activities of girinimbine isolated from .

Drug design, development and therapy Dec 28, 2016
Therapy that directly targets apoptosis and/or inflammation could be highly effective for the treatment of cancer. is an edible herb that has been traditionally used for cancer treatment as well as inflammation. Here, we describe that girinimbine, a...
Humans Cytokines Lipopolysaccharides Dose-Response Relationship, Drug Cell Survival Antineoplastic Agents, Phytogenic Drug Screening Assays, Antitumor Animals Mice Nitric Oxide Cell Proliferation Apoptosis Tumor Cells, Cultured Murraya Structure-Activity Relationship Anti-Inflammatory Agents, Non-Steroidal Zebrafish Alkaloids HT29 Cells
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Anticancer activity of biologically synthesized silver and gold nanoparticles on mouse myoblast cancer cells and their toxicity against embryonic zebrafish.

Materials science & engineering. C, Materials for biological applications Dec 23, 2016
The aim of this study was to evaluate the anticancer activity of bioinspired silver nanoparticles (AgNPs) and gold nanoparticles (AuNPs) against mouse myoblast cancer cells (CC). Both AgNPs and AuNPs were biologically synthesized using Spinacia olera...
Animals Antineoplastic Agents Cell Line, Tumor Mice Staining and Labeling Plant Extracts Silver X-Ray Diffraction Zebrafish Apoptosis Embryo, Nonmammalian Caspases Cell Survival Photoacoustic Techniques Acridine Orange Myoblasts Plant Leaves Spinacia oleracea Toxicity Tests Gold Cell Shape Metal Nanoparticles Ethidium
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Differential cytotoxicity and internalization of graphene family nanomaterials in myocardial cells.

Materials science & engineering. C, Materials for biological applications Dec 23, 2016
Given the well-known physical properties of graphene oxide (GO), numerous applications for this novel nanomaterial have been recently envisioned to improve the performance of biomedical devices. However, the toxicological assessment of GO, which stro...
Endocytosis Nanostructures Graphite Rats Inhibitory Concentration 50 Spectrum Analysis, Raman Animals Cell Line Myocytes, Cardiac Spectroscopy, Fourier Transform Infrared Photoelectron Spectroscopy Cell Survival Oxidation-Reduction Flow Cytometry Cell Death
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Enhanced photostability, radical scavenging and antitumor activity of indole-3-carbinol-loaded rose hip oil nanocapsules.

Materials science & engineering. C, Materials for biological applications Dec 14, 2016
This study aimed to develop poly(ε-caprolactone) nanocapsules loaded with indole-3-cabinol (I3C) using rose hip oil (RHO) or medium chain triglycerides (MCT) as oil core. In vitro radical scavenging activity (DPPH method), hemolysis, and antitumor ef...
Cell Survival MCF-7 Cells Ultraviolet Rays Indoles Materials Testing Humans Solubility Antineoplastic Agents Nanocapsules Oils, Volatile Free Radical Scavengers Cell Line, Tumor Photolysis Rosa
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Synthesis of Water-Soluble Imidazolium Polyesters as Potential Nonviral Gene Delivery Vehicles.

Biomacromolecules Dec 8, 2016
The inherent hydrolytic reactivity of polyesters renders them excellent candidates for a variety of biomedical applications. Incorporating ionic groups further expands their potential impact, encompassing charge-dependent function such as deoxyribonu...
Humans Solubility Transfection HeLa Cells Solvents Polyesters Gene Transfer Techniques Water Cell Survival Imidazoles Luciferases Hydrolysis
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Graphene oxide as a nanocarrier for controlled release and targeted delivery of an anticancer active agent, chlorogenic acid.

Materials science & engineering. C, Materials for biological applications Dec 5, 2016
We have synthesized graphene oxide using improved Hummer's method in order to explore the potential use of the resulting graphene oxide as a nanocarrier for an active anticancer agent, chlorogenic acid (CA). The synthesized graphene oxide and chlorog...
Delayed-Action Preparations Hydrogen Bonding Microscopy, Electron, Transmission Thermogravimetry Drug Liberation HeLa Cells Humans Graphite Cell Survival Antineoplastic Agents Chlorogenic Acid Spectrum Analysis, Raman X-Ray Diffraction A549 Cells Spectroscopy, Fourier Transform Infrared Oxides Hep G2 Cells Hydrogen-Ion Concentration Nanocomposites
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Analysis of bioactive constituents from the leaves of Amorpha fruticosa L.

Journal of food and drug analysis Dec 1, 2016
Amorpha fruticosa L. is a Chinese folk medicine and rich in polyphenols. Fifteen known compounds were isolated and identified from the leaves of A. fruticosa L. They are tephrosin (1), 6a,12a-dehydrodeguelin (2), vitexin (3), afrormosin-7-O-β-d-gluco...
Fabaceae Humans Cell Line, Tumor Plant Extracts Cell Survival Plant Leaves
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