AIMC Topic: Cisplatin
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Utilization of circulating cell-free DNA profiling to guide first-line chemotherapy in advanced lung squamous cell carcinoma.
Theranostics
Jan 1, 2021
Platinum-based chemotherapy is one of treatment mainstay for patients with advanced lung squamous cell carcinoma (LUSC) but it is still a "one-size fits all" approach. Here, we aimed to investigate the predictive and monitoring role of circulating c...
Aged
Survival Rate
Male
Middle Aged
Lung Neoplasms
Humans
Machine Learning
Prognosis
Female
Carcinoma, Squamous Cell
Paclitaxel
Progression-Free Survival
Deoxycytidine
Gemcitabine
Circulating Tumor DNA
Antineoplastic Combined Chemotherapy Protocols
Treatment Outcome
Cell-Free Nucleic Acids
DNA Copy Number Variations
Cisplatin
Network-based machine learning in colorectal and bladder organoid models predicts anti-cancer drug efficacy in patients.
Nature communications
Oct 30, 2020
Cancer patient classification using predictive biomarkers for anti-cancer drug responses is essential for improving therapeutic outcomes. However, current machine-learning-based predictions of drug response often fail to identify robust translational...
Deep learning pathological microscopic features in endemic nasopharyngeal cancer: Prognostic value and protentional role for individual induction chemotherapy.
Cancer medicine
Dec 20, 2019
BACKGROUND: To explore the prognostic value and the role for treatment decision of pathological microscopic features in patients with nasopharyngeal carcinoma (NPC) using the method of deep learning.
Adult
Male
Middle Aged
Risk Assessment
Deep Learning
Humans
Prognosis
Retrospective Studies
Female
Fluorouracil
Progression-Free Survival
Radiotherapy, Intensity-Modulated
Kaplan-Meier Estimate
Chemoradiotherapy
China
Image Processing, Computer-Assisted
Antineoplastic Combined Chemotherapy Protocols
Neoplasm Staging
Cisplatin
Nasopharyngeal Neoplasms
Endemic Diseases
Nasopharynx
Induction Chemotherapy
System-level responses to cisplatin in pro-apoptotic stages of breast cancer MCF-7 cell line.
Computational biology and chemistry
Nov 2, 2019
Cisplatin ceases cell division and induces apoptosis in cancer cell lines. It is well established that cisplatin alters the expression of many genes involved in several cellular processes and pathways including transcription, p53 signaling pathway, a...
Designing combination therapies with modeling chaperoned machine learning.
PLoS computational biology
Sep 9, 2019
Chemotherapy resistance is a major challenge to the effective treatment of cancer. Thus, a systematic pipeline for the efficient identification of effective combination treatments could bring huge biomedical benefit. In order to facilitate rational d...
Design and synthesis of new phthalazine-based derivatives as potential EGFR inhibitors for the treatment of hepatocellular carcinoma.
Bioorganic chemistry
Dec 31, 2018
Searching for new leads in the battle of cancer will never ends, we herein disclose the design and synthesis of new phthalazine derivatives and their in vitro and in vivo testing for their antiproliferative activity. Phthalazine was selected as a pri...
5-fluorouracil combined with cisplatin and mitomycin C as an optimized regimen for hyperthermic intraperitoneal chemotherapy in gastric cancer.
Journal of surgical oncology
Dec 19, 2017
BACKGROUND AND OBJECTIVES: Optimized drug regimens for hyperthermic intraperitoneal chemotherapy (HIPEC) have not been standardized completely in patients with advanced gastric cancer (GC). We evaluated an optimized anti-tumor protocol comprising 5-f...
Cytoprotective Effects of Cell-Permeable Bifunctional Antioxidant Enzyme, GST-TAT-SOD, against Cisplatin-Induced Cell Damage.
Oxidative medicine and cellular longevity
Nov 30, 2017
GST-TAT-SOD, a cell-permeable bifunctional antioxidant enzyme, is a potential selective radioprotector. This study aimed to investigate the cytoprotective activity of GST-TAT-SOD against cisplatin-induced damage. The current study showed that cisplat...
Pharmacokinetic evaluation of intrapleural perfusion with hyperthermic chemotherapy using cisplatin in patients with malignant pleural effusion.
Lung cancer (Amsterdam, Netherlands)
Dec 21, 2016
OBJECTIVES: Malignant pleural effusion (MPE) has a poor prognosis. Most patients are treated with tube thoracostomy and sclerotherapy, although its success rate is around 64%. We have investigated intrapleural perfusion with hyperthermic chemotherapy...
Correlation of Serum Cystatin C with Glomerular Filtration Rate in Patients Receiving Platinum-Based Chemotherapy.
Analytical cellular pathology (Amsterdam)
Dec 18, 2016
. Serum cystatin C seems to be an accurate marker of glomerular filtration rate (GFR) compared to serum creatinine. The aim of this work was to explore the possibility of using serum cystatin C instead of serum creatinine to early predict renal failu...
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