Klinicka mikrobiologie a infekcni lekarstvi
39808469
INTRODUCTION: Staphylococcus aureus is a gram-positive, facultatively anaerobic coccus capable of causing infectious diseases in animals and humans. Especially dangerous are multidrug-resistant forms with poor or even no response to available treatme...
Advances in experimental medicine and biology
39930228
Retinal degenerative diseases caused by retinal pigment epithelium (RPE) dysfunction affect specific areas of the retina. Regions of molecular and phenotypic RPE heterogeneity have been described in the human eye and are thought to underlie geographi...
Methods in molecular biology (Clifton, N.J.)
39900768
A significantly low success rate of human clinical studies has long been attributed to a capability gap, namely, an ineffective translation of the animal data to the human context. To bridge this capability gap, several correcting measures have been ...
Approximately 30%-40% of epilepsy patients do not respond well to adequate anti-seizure medications (ASMs), a condition known as pharmacoresistant epilepsy. The management of pharmacoresistant epilepsy remains an intractable issue in the clinic. Its ...
Epilepsy, a neurological disorder causing recurring seizures, is often studied in zebrafish by exposing animals to pentylenetetrazol (PTZ), which induces clonic- and tonic-like behaviors. While adult zebrafish seizure-like behaviors are well characte...
The quantitative evaluation of motor function in experimental stroke models is essential for the preclinical assessment of new therapeutic strategies that can be transferred to clinical research; however, conventional assessment tests are hampered by...
Parkinson's disease (PD), as the second most prevalent neurodegenerative disorder worldwide, impacts the quality of life for over 12 million patients. This study aims to enhance the accuracy of early diagnosis of PD through non-invasive methods, with...
Accurate diagnosis is essential for effective cancer treatment, particularly in peritoneal surface malignancies, where failure to detect metastatic lesions can mislead the treatment plan. This study assessed the diagnostic accuracy of staging laparos...
International journal of biological macromolecules
39929468
Oxidative stress (OS) is a pivotal mechanism driving the progression of cardiovascular diseases, particularly heart failure (HF). However, the comprehensive characterisation of OS-related genes in HF remains largely unexplored. In the present study, ...
PURPOSE: We present RetOCTNet, a deep learning tool to segment the retinal nerve fiber layer (RNFL) and total retinal thickness automatically from optical coherence tomography (OCT) scans in rats following retinal ganglion cell (RGC) injury.