AIMC Topic: Disease Models, Animal

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Exploring the role of cytochrome P450 family 1 subfamily B member 1 and quercetin in modulating neuropathic pain after spinal cord injury.

Molecular medicine reports
Spinal cord injury (SCI) represents a notable global health challenge, with neuropathic pain (NP) being a common complication that intensifies patient suffering. Existing research tends to overlook the temporal aspects of NP and fails to offer target...

Integrated machine learning identifies biomarkers for bilirubin-induced Alzheimer's disease-like lesions in neonates and adults.

Scientific reports
Neurological impairments resulting from bilirubin encephalopathy represent a hallmark of bilirubin's neurotoxic effects. Earlier research suggests that bilirubin may contribute to Alzheimer's disease (AD) pathology by inducing neuronal necrosis and a...

Integrative transcriptomic and genomic insights into diabetic kidney disease: evidence from multi-omics analysis and experimental validation.

Renal failure
Diabetic kidney disease (DKD) remains a critical challenge in diabetes management, necessitating a deep understanding of its molecular underpinnings for better diagnosis and treatment strategies. This study was conducted to identify and validate nove...

Zhilining formula alleviates ulcerative colitis by restricting STAT3 activation and subsequent Th17 cell differentiation.

Phytomedicine : international journal of phytotherapy and phytopharmacology
BACKGROUND: Ulcerative colitis (UC) is a chronic, relapsing inflammatory bowel disease with rising prevalence and limited therapies. Zhilining Formula (ZLN), a Traditional Chinese Medicine (TCM), shows clinical efficacy in UC, yet its core material b...

Identification and validation of aryl hydrocarbon receptor-associated hub genes in ulcerative colitis via integrated bioinformatics analysis.

Human genomics
OBJECTIVE: Ulcerative colitis (UC), a chronic inflammatory bowel disease, continues to pose substantial challenges in both diagnosis and treatment. The aryl hydrocarbon receptor (AhR) plays a pivotal role in intestinal immune regulation; however, its...

Combining gamma neuromodulation and robotic rehabilitation after a stroke restores parvalbumin interneuron dynamics and improves motor recovery in mice.

PLoS biology
Stroke is a leading cause of long-term disability, frequently associated with persistent motor deficits. Gamma band oscillations, generated by synchronous discharge of parvalbumin-positive interneurons (PV-INs), are critically affected after stroke i...

Integrating spatial and chemical information enhances differentiation of non-alcoholic steatohepatitis states in Raman imaging.

Scientific reports
Machine learning studies for Raman imaging have addressed the differentiability of normal and diseased states in biomedical applications by grouping a set of Raman spectra in terms of spectral similarity over the sample. However, Raman imaging provid...

Linarin protects against asthma-induced airway epithelial ferroptosis and inflammation via ALDH2 regulation.

Phytomedicine : international journal of phytotherapy and phytopharmacology
BACKGROUND: Asthma, a complex disease characterized by airway epithelial dysfunction and chronic inflammation, poses ongoing therapeutic challenges.

Characterization of SPTLC2 as a key driver promoting microglial activation and energy metabolism reprogramming after ischemic stroke through bulk and single-cell analyses combined with experimental validation.

Cell biology and toxicology
BACKGROUND: Ischemic stroke (IS) stands as a principal contributor to high rates of sickness and death. The condition's pathological development is complicated, featuring mechanisms like mitochondrial impairment and the activation of microglial cells...

Screening and experimental study of potential biomarkers for ulcerative colitis based on weighted gene co-expression network analysis and machine learning.

Journal of translational medicine
BACKGROUND: Ulcerative colitis (UC) is a chronic nonspecific inflammatory intestinal disease affecting the mucosa and submucosa, characterized by continuous and diffuse active inflammation. However, its underlying pathogenesis remains unclear.