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Assessment of the transmission of live-attenuated chikungunya virus vaccine VLA1553 by Aedes albopictus mosquitoes.
Parasites & vectors
May 12, 2025
BACKGROUND: Chikungunya virus (CHIKV) is a mosquito-transmitted, arthritogenic alphavirus that causes sporadic outbreaks of often debilitating rheumatic disease. The recently approved CHIKV vaccine, IXCHIQ, is based on a live-attenuated CHIKV strain ...
Development of a chitosanase 3-like protein 1 assay kit and study of its application in patients with hepatocellular carcinoma.
BMC biotechnology
May 12, 2025
OBJECTIVE: The detection kit for plasma Chitinase-3-like Protein 1 was developed using the magnetic bead chemiluminescence method, in order to investigate the diagnostic value of DD, FDP, CHI3L1, AFP-L3 and PIVKA-II in hepatocellular carcinoma.
A potential new strategy for BC treatment: NPs containing solanine and evaluation of its anticancer and antimetastatic properties.
BMC cancer
May 12, 2025
Solanine has been shown to inhibit cancer by regulating the expression of apoptosis (Bax, Bcl-2) and metastasis (CDH-1, MMP2) genes in various cancer cell types. We synthesized optimized niosome NPs (NPs) with high solubility and capacity for solanin...
A controlled trial examining large Language model conformity in psychiatric assessment using the Asch paradigm.
BMC psychiatry
May 12, 2025
BACKGROUND: Despite significant advances in AI-driven medical diagnostics, the integration of large language models (LLMs) into psychiatric practice presents unique challenges. While LLMs demonstrate high accuracy in controlled settings, their perfor...
Minimum clinically important difference in Quantitative Lung Fibrosis score associated with all-cause mortality in idiopathic pulmonary fibrosis: subanalysis from two phase II trials of pamrevlumab.
BMJ open
May 12, 2025
OBJECTIVES: Idiopathic pulmonary fibrosis (IPF) is a progressive interstitial lung disease. Chest high-resolution CT (HRCT) is instrumental in IPF management, and the Quantitative Lung Fibrosis (QLF) score is a computer-assisted metric for quantifyin...
Clinical Value of ChatGPT for Epilepsy Presurgical Decision-Making: Systematic Evaluation of Seizure Semiology Interpretation.
Journal of medical Internet research
May 12, 2025
BACKGROUND: For patients with drug-resistant focal epilepsy, surgical resection of the epileptogenic zone (EZ) is an effective treatment to control seizures. Accurate localization of the EZ is crucial and is typically achieved through comprehensive p...
Reinforcement Learning-Driven Path Generation for Ankle Rehabilitation Robot Using Musculoskeletal-Informed Energy Optimization.
IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society
May 12, 2025
In rehabilitation robotics, optimizing energy consumption and high interaction forces is essential to prevent unnecessary muscle fatigue and excessive joint loading as they often cause an inefficient trajectory planning and disrupt natural movement p...
Investigation of serum neuroserpin levels in pregnant women diagnosed with pre-eclampsia: a prospective case-control study.
BMC pregnancy and childbirth
May 10, 2025
OBJECTIVE: Neuroserpin, a serine protease inhibitor, is recognized for its anti-inflammatory and neuroprotective properties. Given the central role of inflammation and neurological involvement in the pathophysiology of preeclampsia, this study aimed ...
Maternal and umbilical cord plasma purine concentrations after oral carbohydrate loading prior to elective Cesarean delivery under spinal anesthesia: a randomized controlled trial.
BMC pregnancy and childbirth
May 10, 2025
OBJECTIVE: To evaluate the effect of preoperative intake of oral carbohydrates versus standard preoperative fasting prior to elective cesarean delivery on plasma purine levels (hypoxanthine, xanthine, and uric acid) and beta-hydroxybutyrate (β-HB) in...
High procalcitonin level is related to blood stream infections, gram-negative pathogens, and ICU admission in infections of adult febrile cancer patients.
Journal of the Egyptian National Cancer Institute
May 10, 2025
BACKGROUND: Blood stream infection (BSI) represent a life-threatening condition. Thus, we aimed to investigate the role of procalcitonin (PCT) and C-reactive protein (CRP) tests in adult febrile patients with BSI and other clinical infections in hosp...
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