AIMC Topic: Fibroblasts
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Identifying Explainable Machine Learning Models and a Novel SFRP2 Fibroblast Signature as Predictors for Precision Medicine in Ovarian Cancer.
International journal of molecular sciences
Nov 29, 2023
Ovarian cancer (OC) is a type of malignant tumor with a consistently high mortality rate. The diagnosis of early-stage OC and identification of functional subsets in the tumor microenvironment are essential to the development of patient management st...
Machine learning and single-cell transcriptome profiling reveal regulation of fibroblast activation through THBS2/TGFβ1/P-Smad2/3 signalling pathway in hypertrophic scar.
International wound journal
Nov 20, 2023
Hypertrophic scar (HS) is a chronic inflammatory skin disorder characterized by excessive deposition of extracellular matrix, and the mechanisms underlying their formation remain poorly understood. We analysed scRNA-seq data from samples of normal sk...
Self-supervised classification of subcellular morphometric phenotypes reveals extracellular matrix-specific morphological responses.
Scientific reports
Sep 12, 2022
Cell morphology is profoundly influenced by cellular interactions with microenvironmental factors such as the extracellular matrix (ECM). Upon adhesion to specific ECM, various cell types are known to exhibit different but distinctive morphologies, s...
Integrating deep learning and unbiased automated high-content screening to identify complex disease signatures in human fibroblasts.
Nature communications
Mar 25, 2022
Drug discovery for diseases such as Parkinson's disease are impeded by the lack of screenable cellular phenotypes. We present an unbiased phenotypic profiling platform that combines automated cell culture, high-content imaging, Cell Painting, and dee...
Identification of Synovial Fibroblast-Associated Neuropeptide Genes and m6A Factors in Rheumatoid Arthritis Using Single-Cell Analysis and Machine Learning.
Disease markers
Feb 9, 2022
OBJECTIVES: Synovial fibroblasts (SFs) play an important role in the development and progression of rheumatoid arthritis (RA). However, the pathogenic mechanism of SFs remains unclear. The objective of this study was to investigate how neuropeptides ...
Morphological features of single cells enable accurate automated classification of cancer from non-cancer cell lines.
Scientific reports
Dec 21, 2021
Accurate cancer detection and diagnosis is of utmost importance for reliable drug-response prediction. Successful cancer characterization relies on both genetic analysis and histological scans from tumor biopsies. It is known that the cytoskeleton is...
A deep learning approach to identify and segment alpha-smooth muscle actin stress fiber positive cells.
Scientific reports
Nov 8, 2021
Cardiac fibrosis is a pathological process characterized by excessive tissue deposition, matrix remodeling, and tissue stiffening, which eventually leads to organ failure. On a cellular level, the development of fibrosis is associated with the activa...
Soft robotic constrictor for in vitro modeling of dynamic tissue compression.
Scientific reports
Aug 13, 2021
Here we present a microengineered soft-robotic in vitro platform developed by integrating a pneumatically regulated novel elastomeric actuator with primary culture of human cells. This system is capable of generating dynamic bending motion akin to th...
Comparative mapping of crawling-cell morphodynamics in deep learning-based feature space.
PLoS computational biology
Aug 12, 2021
Navigation of fast migrating cells such as amoeba Dictyostelium and immune cells are tightly associated with their morphologies that range from steady polarized forms that support high directionality to those more complex and variable when making fre...
Application of Machine-Learning Methods to Recognize mitoBK Channels from Different Cell Types Based on the Experimental Patch-Clamp Results.
International journal of molecular sciences
Jan 15, 2021
(1) Background: In this work, we focus on the activity of large-conductance voltage- and Ca2+-activated potassium channels (BK) from the inner mitochondrial membrane (mitoBK). The characteristic electrophysiological features of the mitoBK channels ar...
Ion Channel Gating
Patch-Clamp Techniques
Large-Conductance Calcium-Activated Potassium Channels
Potassium Channels
Protein Conformation
Endothelium
Animals
Pregnancy, Animal
Algorithms
Neural Networks, Computer
Fibroblasts
Mitochondria
Rats, Wistar
Pregnancy
Artificial Intelligence
Kinetics
Hippocampus
Rats
Female
Machine Learning
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