AIMC Topic: Gene Regulatory Networks
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Anoikis-related biomarkers PARP1 and SDCBP as diagnostic and therapeutic targets for asthma.
Scientific reports
Jul 9, 2025
This study aims to explore the association between anoikis-related genes (ARGs) and asthma. The dataset GSE143303 for asthma were sourced from the GEO database, while ARGs were retrieved from the Harmonizome web portal and the GeneCards database. Dif...
Machine learning using genotype and gene-expression data identifies alterations of genes involved in infection susceptibility, antigen presentation and cytokine signalling as key contributors to JIA risk prediction.
RMD open
Jul 9, 2025
BACKGROUND: Previous genome-wide association studies (GWAS) have identified numerous genetic loci associated with juvenile idiopathic arthritis (JIA). However, the functional impact of these variants-particularly on tissue-specific gene expression-an...
Integrated analysis of WGCNA and machine learning identified diagnostic biomarkers in trauma-induced coagulopathy.
Scientific reports
Jul 8, 2025
Despite advancements in trauma care, uncontrolled hemorrhage and trauma-induced coagulopathy (TIC) remain the leading causes of preventable deaths after trauma. Understanding the genetic underpinnings and molecular mechanisms of TIC is crucial for de...
Identifying propionate metabolism-related genes as biomarkers of sepsis development and therapeutic targets.
Scientific reports
Jul 8, 2025
The treatment of sepsis is challenging due to unclear mechanisms. Propionate is increasingly seen as critical to sepsis pathophysiology by bridging gut microbiota and immunity, but the mechanisms remain unclear. Our study analysed differences in prop...
Machine learning identifies KRT8 dysregulation and endothelial remodeling in Moyamoya disease.
Scientific reports
Jul 7, 2025
Moyamoya disease (MMD) is a rare occlusive cerebrovascular disease, and its pathological mechanism remains unclear at present. The abnormal vascular remodeling may be involved in vascular endothelial cells. In this study, RNA seq was performed on the...
Identification and validation of glucocorticoid receptor and programmed cell death-related genes in spinal cord injury using machine learning.
Scientific reports
Jul 7, 2025
Spinal cord injury (SCI) is a severe neurological disorder, with glucocorticoids like methylprednisolone commonly used for treatment. However, their efficacy and risks remain controversial. Programmed cell death (PCD) mechanisms have been increasingl...
Early transcriptional responses reveal cell type-specific vulnerability and neuroprotective mechanisms in the neonatal ischemic hippocampus.
Acta neuropathologica communications
Jul 5, 2025
Neonatal hypoxic-ischemic (H-I) brain injury, a leading cause of neurodevelopmental disabilities, severely affects the metabolically active and neurogenic hippocampus. To investigate its acute effects and identify drug targets for early therapeutic w...
Combination of machine learning and protein‑protein interaction network established one ATM‑DPP4‑TXN ferroptotic diagnostic model with experimental validation.
Molecular medicine reports
Jul 4, 2025
Ferroptosis and lethal sepsis are interlinked, although this association remains largely unknown to clinical panels. Sepsis is characterized by dysfunction of the inflammatory microenvironment. Most septic biomarkers lack independent validation, and ...
Uncovering key markers and therapeutic targets for renal fibrosis in diabetic kidney disease through bulk and single-cell RNA sequencing.
Journal of translational medicine
Jul 4, 2025
BACKGROUND: Diabetic kidney disease (DKD) is the major cause of chronic kidney failure, with tubulointerstitial fibrosis playing a crucial role in disease development. Identifying fibrosis-related genes is crucial for improving diagnosis and developi...
Identification and single-cell analysis of prognostic genes related to mitochondrial and neutrophil extracellular traps in bladder cancer.
Scientific reports
Jul 4, 2025
The development of bladder cancer (BLCA) is associated with mitochondrial dysfunction and neutrophil extracellular traps (NETs); however, the relationship between mitochondrial function and NET formation in BLCA remains poorly understood. In this stu...
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