AIMC Topic: Middle Aged

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Breast lesion classification based on supersonic shear-wave elastography and automated lesion segmentation from B-mode ultrasound images.

Computers in biology and medicine
Supersonic shear-wave elastography (SWE) has emerged as a useful imaging modality for breast lesion assessment. Regions of interest (ROIs) were required to be specified for extracting features that characterize malignancy of lesions. Although analyse...

Automatic Detection of Acromegaly From Facial Photographs Using Machine Learning Methods.

EBioMedicine
BACKGROUND: Automatic early detection of acromegaly is theoretically possible from facial photographs, which can lessen the prevalence and increase the cure probability.

Resolution of type 2 diabetes after sleeve gastrectomy: a 2-step hypothesis.

Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery
BACKGROUND: Weight loss (WL) and altered gut hormonal levels are involved in glucose homeostasis after laparoscopic sleeve gastrectomy (LSG).

A 29-gene and cytogenetic score for the prediction of resistance to induction treatment in acute myeloid leukemia.

Haematologica
Primary therapy resistance is a major problem in acute myeloid leukemia treatment. We set out to develop a powerful and robust predictor for therapy resistance for intensively treated adult patients. We used two large gene expression data sets (n=856...

Mechanisms of pulse pressure amplification dipping pattern during sleep time: the SAFAR study.

Journal of the American Society of Hypertension : JASH
The difference in pulse pressure (PP) between peripheral arteries and the aorta, called pulse pressure amplification (PPamp), is a well-described physiological phenomenon independently associated with cardiovascular events. Recent studies suggest tha...

Machine-Learning Classifier for Patients with Major Depressive Disorder: Multifeature Approach Based on a High-Order Minimum Spanning Tree Functional Brain Network.

Computational and mathematical methods in medicine
High-order functional connectivity networks are rich in time information that can reflect dynamic changes in functional connectivity between brain regions. Accordingly, such networks are widely used to classify brain diseases. However, traditional me...

Efficacy and safety of lebrikizumab in adult patients with mild-to-moderate asthma not receiving inhaled corticosteroids.

Respiratory medicine
BACKGROUND: Asthma is a heterogeneous and complex disease in both its clinical course and response to treatment. IL-13 is central to Type 2 inflammation and contributes to many features of asthma. In a previous Phase 2 study, lebrikizumab, an anti-IL...

Melatonin administration lowers biomarkers of oxidative stress and cardio-metabolic risk in type 2 diabetic patients with coronary heart disease: A randomized, double-blind, placebo-controlled trial.

Clinical nutrition (Edinburgh, Scotland)
BACKGROUND & AIMS: Melatonin may benefit diabetic people with coronary heart disease (CHD) through its beneficial effects on biomarkers of oxidative stress and cardio-metabolic risk. This investigation evaluated the effects of melatonin administratio...