AIMC Topic: Tumor Necrosis Factor-alpha
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E. globulus leaf EO exhibits anti-inflammatory effects by regulating GSDMD-mediated pyroptosis, thereby alleviating neurological impairment and neuroinflammation in experimental stroke mice.
Journal of ethnopharmacology
Oct 30, 2023
ETHNOPHARMACOLOGICAL RELEVANCE: Aromatic and medicinal plants continue to be a major component of alternative and traditional medicine in the developing countries. Eucalyptus globulus (Labill.) is being employed to cultivation and production in China...
Plant Leaves
Neuroinflammatory Diseases
Microglia
NF-kappa B
Anti-Infective Agents
NLR Family, Pyrin Domain-Containing 3 Protein
Mice
Anti-Inflammatory Agents
Tumor Necrosis Factor-alpha
Rats
Pyroptosis
Interleukin-6
Inflammation
Stroke
Animals
Rats, Sprague-Dawley
Infarction, Middle Cerebral Artery
Lipopolysaccharides
DNA-Binding Proteins
Leptin levels in childhood tuberculosis and its correlation with body mass index, IFN-γ, and TNF-α in an Indonesian population.
The Indian journal of tuberculosis
Mar 31, 2023
BACKGROUND: Leptin plays a key role in the regulation of energy and inflammation in tuberculosis (TB). However, its correlation in children with TB remains unclear. Therefore, this study aimed to evaluate the correlations between body mass index, IFN...
Exposure to nitrate induces alterations in blood parameter responses, liver immunity, and lipid metabolism in juvenile turbot (Scophthalmus maximus).
Aquatic toxicology (Amsterdam, Netherlands)
Aug 24, 2022
Nitrate (NO) pollution of waterbodies has attracted significant global attention as it poses a serious threat to aquatic organisms and human beings. This study aimed to evaluate the role of NO, an end product of biological nitrification processes, in...
Sterol Regulatory Element Binding Protein 1
Flatfishes
Complement C4
Liver X Receptors
Muramidase
Humans
Immunoglobulin M
Tumor Necrosis Factor-alpha
Complement C3
Fish Proteins
Animals
Peroxisome Proliferator-Activated Receptors
RNA, Messenger
Heat-Shock Proteins
Carnitine O-Palmitoyltransferase
Water Pollutants, Chemical
Nitrates
Liver
Alanine Transaminase
Lipid Metabolism
Aspartate Aminotransferases
Influences of Edaravone on Necroptosis-Related Proteins and Oxidative Stress in Rats with Lower Extremity Ischemia/Reperfusion Injury.
Cellular and molecular biology (Noisy-le-Grand, France)
Jul 31, 2022
The study aimed to investigate the influences of edaravone on necroptosis-related proteins and oxidative stress in rats with lower extremity ischemia/reperfusion (I/R) injury. The normal group (n=10), model group (lower extremity I/R injury model, n=...
Effect of clove on improving running ability in aging mice.
Journal of food biochemistry
Jul 19, 2022
In this study, a D-galactose-induced aging mouse model was established, and Syringa oblata Lindl. extract (SOLE) was administered orally to observe the effect and mechanism of SOLE on the running ability of aging mice. The role of SOLE was evaluated ...
Caffeoyl malic acid is a potential dual inhibitor targeting TNFα/IL-4 evaluated by a combination strategy of network analysis-deep learning-molecular simulation.
Computers in biology and medicine
Mar 17, 2022
Atopic dermatitis (AD) is a common inflammatory skin disease involving multiple signaling pathways. One of the effective treatment strategies of AD is to develop a new drug capable of regulating the key therapeutic targets. Here we report the combina...
Combining explainable machine learning, demographic and multi-omic data to inform precision medicine strategies for inflammatory bowel disease.
PloS one
Feb 23, 2022
Inflammatory bowel diseases (IBDs), including ulcerative colitis and Crohn's disease, affect several million individuals worldwide. These diseases are heterogeneous at the clinical, immunological and genetic levels and result from complex host and en...
Humans
Colitis, Ulcerative
Machine Learning
Phenylurea Compounds
Anti-Inflammatory Agents, Non-Steroidal
Tumor Necrosis Factor-alpha
Naphthalenes
Crohn Disease
Precision Medicine
Middle Aged
Prednisolone
Female
Drug Evaluation, Preclinical
Transcriptome
Mesalamine
Aged
Pyrazoles
Adolescent
Young Adult
Genomics
Adult
Signal Transduction
Male
Contribution of phosphorus and PTH to the development of cardiac hypertrophy and fibrosis in an experimental model of chronic renal failure.
Nefrologia
Jan 3, 2022
BACKGROUND AND OBJECTIVE: Adequate serum phosphorus levels in patients with chronic kidney disease is essential for their clinical management. However, the control of hyperphosphatemia is difficult because is normally associated with increases in ser...
Association of TLR 9 gene polymorphisms with remission in patients with rheumatoid arthritis receiving TNF-α inhibitors and development of machine learning models.
Scientific reports
Oct 11, 2021
Toll-like receptor (TLR)-4 and TLR9 are known to play important roles in the immune system, and several studies have shown their association with the development of rheumatoid arthritis (RA) and regulation of tumor necrosis factor alpha (TNF-α). Howe...
Analysis of cognitive impairment in schizophrenia based on machine learning: Interaction between psychological stress and immune system.
Neuroscience letters
Jun 24, 2021
The interaction between psychological stress and immune system may be associated with the cognitive impairment of schizophrenia. To employ machine learning algorithms to examine patterns of stress-immune networks with cognitive impairment in chronic ...
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