AIMC Topic: Cell Differentiation
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Prospective identification of hematopoietic lineage choice by deep learning.
Nature methods
Feb 20, 2017
Differentiation alters molecular properties of stem and progenitor cells, leading to changes in their shape and movement characteristics. We present a deep neural network that prospectively predicts lineage choice in differentiating primary hematopoi...
Impact of chromogranin A, differentiation, and mitoses in nonfunctional pancreatic neuroendocrine tumors ≤ 2 cm.
The Journal of surgical research
Dec 29, 2016
BACKGROUND: Small pancreatic neuroendocrine tumors (PNETs) are a unique subset of pancreatic neoplasms. Chromogranin A (CgA) levels, mitotic rate, and histologic differentiation are often used to characterize PNET behavior. This study evaluates the i...
Chromogranin A
Mitosis
Neuroendocrine Tumors
Adult
Neoplasm Staging
Survival Analysis
Biomarkers, Tumor
Multivariate Analysis
Male
Propensity Score
Middle Aged
Adolescent
Logistic Models
Pancreatic Neoplasms
Cell Differentiation
Humans
Databases, Factual
Female
Prognosis
Aged
Retrospective Studies
Aged, 80 and over
Young Adult
Basic fibroblast growth factor is critical to reprogramming buffalo (Bubalus bubalis) primordial germ cells into embryonic germ stem cell-like cells.
Theriogenology
Dec 29, 2016
Primordial germ cells (PGCs) are destined to form gametes in vivo, and they can be reprogrammed into pluripotent embryonic germ (EG) cells in vitro. Buffalo PGC have been reported to be reprogrammed into EG-like cells, but the identities of the major...
Texture Descriptors Ensembles Enable Image-Based Classification of Maturation of Human Stem Cell-Derived Retinal Pigmented Epithelium.
PloS one
Feb 19, 2016
AIMS: A fast, non-invasive and observer-independent method to analyze the homogeneity and maturity of human pluripotent stem cell (hPSC) derived retinal pigment epithelial (RPE) cells is warranted to assess the suitability of hPSC-RPE cells for impla...
Effect of Short-Term Stimulation with Interleukin-1β and Differentiation Medium on Human Mesenchymal Stromal Cell Paracrine Activity in Coculture with Osteoblasts.
BioMed research international
Dec 22, 2015
INTRODUCTION: Human mesenchymal stromal cells (hMSCs) exhibit the potential to accelerate bone healing by enhanced osteogenic differentiation. Interleukin-1β is highly expressed during fracture healing and has been demonstrated to exert a significant...
Knowledge-Based Analysis for Detecting Key Signaling Events from Time-Series Phosphoproteomics Data.
PLoS computational biology
Aug 7, 2015
Cell signaling underlies transcription/epigenetic control of a vast majority of cell-fate decisions. A key goal in cell signaling studies is to identify the set of kinases that underlie key signaling events. In a typical phosphoproteomics study, phos...
Automated, high-throughput derivation, characterization and differentiation of induced pluripotent stem cells.
Nature methods
Aug 3, 2015
Induced pluripotent stem cells (iPSCs) are an essential tool for modeling how causal genetic variants impact cellular function in disease, as well as an emerging source of tissue for regenerative medicine. The preparation of somatic cells, their repr...
Scalable 96-well Plate Based iPSC Culture and Production Using a Robotic Liquid Handling System.
Journal of visualized experiments : JoVE
May 14, 2015
Continued advancement in pluripotent stem cell culture is closing the gap between bench and bedside for using these cells in regenerative medicine, drug discovery and safety testing. In order to produce stem cell derived biopharmaceutics and cells fo...
Discovering novel type I collagen fragments from Cyprinus carpio supporting bone regeneration.
Functional & integrative genomics
Jul 4, 2025
Fish collagen is gaining increasing attention in tissue engineering due to its exceptional bioactivity. This study aimed to isolate functional fish collagen fragments capable of microbial biosynthesis and supporting bone tissue regeneration. Collagen...
A method for evaluating the degree of Adipogenic differentiation of porcine cells cultured in suspension based on deep learning.
Food research international (Ottawa, Ont.)
Jul 1, 2025
Fat plays a very important role in the quality of meat and meat products. Cell culture based adipocyte differentiation is a crucial step in the production of cell-cultured meat, traditionally relying on quantitative assessments through fluorescence s...
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