AIMC Topic: Cell Line, Tumor
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Integrative modeling of multi-omics data to identify cancer drivers and infer patient-specific gene activity.
BMC systems biology
Feb 11, 2016
BACKGROUND: High throughput technologies have been used to profile genes in multiple different dimensions, such as genetic variation, copy number, gene and protein expression, epigenetics, metabolomics. Computational analyses often treat these differ...
Monitoring vascular normalization induced by antiangiogenic treatment with (18)F-fluoromisonidazole-PET.
Molecular oncology
Dec 22, 2015
BACKGROUND: Rationalization of antiangiogenics requires biomarkers. Vascular re-normalization is one widely accepted mechanism of action for this drug class. The interstitium of tumors with abnormal vasculature is hypoxic. We sought to track vascular...
Antimetabolites, Antineoplastic
Deoxycytidine
Gemcitabine
Misonidazole
Pancreatic Neoplasms
Breast
Positron-Emission Tomography
Quinolones
Neovascularization, Pathologic
Pancreas
Cell Hypoxia
Fluorine Radioisotopes
Benzimidazoles
Animals
Cell Line, Tumor
Mice
Angiogenesis Inhibitors
Mice, Nude
Humans
Female
Breast Neoplasms
Preparation, Characterization, and Antitumor Activities of Miriplatin-Loaded Liposomes.
Journal of pharmaceutical sciences
Dec 22, 2015
Because of the insolubility of miriplatin in water, miriplatin and lipiodol suspension is the sole formulation of miriplatin approved in Japan to treat hepatocellular carcinoma by transcatheter arterial chemoembolization. Until now, there have been n...
Effect of Short-Term Stimulation with Interleukin-1β and Differentiation Medium on Human Mesenchymal Stromal Cell Paracrine Activity in Coculture with Osteoblasts.
BioMed research international
Dec 22, 2015
INTRODUCTION: Human mesenchymal stromal cells (hMSCs) exhibit the potential to accelerate bone healing by enhanced osteogenic differentiation. Interleukin-1β is highly expressed during fracture healing and has been demonstrated to exert a significant...
O-naphthoquinone isolated from Capraria biflora L. induces selective cytotoxicity in tumor cell lines.
Genetics and molecular research : GMR
Dec 21, 2015
Biflorin is an o-naphthoquinone isolated from the roots of the plant Capraria biflora L. (Scrophulariaceae). In this study, the cytotoxic effects of biflorin were verified, and late apoptosis was detected in various cancer cell lines by in situ analy...
Preparation, characterization and biocompatibility studies of thermoresponsive eyedrops based on the combination of nanostructured lipid carriers (NLC) and the polymer Pluronic F-127 for controlled delivery of ibuprofen.
Pharmaceutical development and technology
Dec 20, 2015
CONTEXT: Nanostructured lipid carrier (NLC) dispersions present low viscosity and poor mucoadhesive properties, which reduce the pre-corneal residence time and consequently, the bioavailability of ocular drugs.
canSAR: an updated cancer research and drug discovery knowledgebase.
Nucleic acids research
Dec 15, 2015
canSAR (http://cansar.icr.ac.uk) is a publicly available, multidisciplinary, cancer-focused knowledgebase developed to support cancer translational research and drug discovery. canSAR integrates genomic, protein, pharmacological, drug and chemical da...
In-Vivo Imaging of Cell Migration Using Contrast Enhanced MRI and SVM Based Post-Processing.
PloS one
Dec 14, 2015
The migration of cells within a living organism can be observed with magnetic resonance imaging (MRI) in combination with iron oxide nanoparticles as an intracellular contrast agent. This method, however, suffers from low sensitivity and specificty. ...
Neuroprotective effects of the Phellinus linteus ethyl acetate extract against H2O2-induced apoptotic cell death of SK-N-MC cells.
Nutrition research (New York, N.Y.)
Nov 11, 2015
Numerous studies have suggested that neuronal cells are protected against oxidative stress-induced cell damage by antioxidants, such as polyphenolic compounds. Phellinus linteus (PL) has traditionally been used to treat various symptoms in East Asian...
Humans
Brain
Republic of Korea
Cell Line, Tumor
Oxidative Stress
Polyphenols
Nerve Tissue Proteins
Acetates
Polysaccharides
Neurons
Antioxidants
Plant Extracts
Neuroprotective Agents
Apoptosis
Biological Products
Gene Expression Regulation, Enzymologic
Oxidoreductases
Ethnopharmacology
Medicine, Korean Traditional
Solvents
Phellinus
MAP Kinase Signaling System
Basidiomycota
Fruiting Bodies, Fungal
Modulatory role of garlicin in migration and invasion of intrahepatic cholangiocarcinoma via PI3K/AKT pathway.
International journal of clinical and experimental pathology
Nov 1, 2015
Increasing evidences have indicated the role of garlicin in inhibiting the progression of various tumors including glioma, pulmonary carcinoma and pancreatic carcinoma, via mediating cell apoptosis or cell cycle. The regulatory effect and related mol...
Protein Kinase Inhibitors
Cholangiocarcinoma
Phosphatidylinositol 3-Kinase
Phosphoinositide-3 Kinase Inhibitors
Phosphorylation
Proto-Oncogene Proteins c-akt
Bile Duct Neoplasms
Disulfides
Allyl Compounds
Cell Movement
Neoplasm Invasiveness
Dose-Response Relationship, Drug
Humans
Antineoplastic Agents, Phytogenic
Cell Line, Tumor
Cell Proliferation
Signal Transduction
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