AIMC Topic: Disease Models, Animal

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Machine learning discriminates a movement disorder in a zebrafish model of Parkinson's disease.

Disease models & mechanisms Oct 16, 2020
Animal models of human disease provide an system that can reveal molecular mechanisms by which mutations cause pathology, and, moreover, have the potential to provide a valuable tool for drug development. Here, we have developed a zebrafish model of...
Algorithms Movement Brain Dopaminergic Neurons Animals Gene Expression Profiling Movement Disorders Machine Learning Disease Models, Animal Gene Targeting Parkinson Disease Protein Deglycase DJ-1 Mutation Alleles Zebrafish Base Sequence
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Data mining of human plasma proteins generates a multitude of highly predictive aging clocks that reflect different aspects of aging.

Aging cell Oct 8, 2020
We previously identified 529 proteins that had been reported by multiple different studies to change their expression level with age in human plasma. In the present study, we measured the q-value and age coefficient of these proteins in a plasma prot...
Blood Proteins Data Mining Longevity Aged Young Adult Adult Animals Aging Middle Aged Adolescent Mice Disease Models, Animal Humans Machine Learning
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Machine learning based white matter models with permeability: An experimental study in cuprizone treated in-vivo mouse model of axonal demyelination.

NeuroImage Oct 6, 2020
The intra-axonal water exchange time (τ), a parameter associated with axonal permeability, could be an important biomarker for understanding and treating demyelinating pathologies such as Multiple Sclerosis. Diffusion-Weighted MRI (DW-MRI) is sensiti...
Mice Disease Models, Animal Permeability Axons Microscopy, Electron Machine Learning Computer Simulation Animals Image Processing, Computer-Assisted Corpus Callosum Monte Carlo Method Monoamine Oxidase Inhibitors White Matter Cuprizone Demyelinating Diseases Diffusion Magnetic Resonance Imaging
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Lignin-Incorporated Nanogel Serving As an Antioxidant Biomaterial for Wound Healing.

ACS applied bio materials Oct 1, 2020
Oxidative phosphorylation is an important biological process in the body to produce energy, during which oxygen free radicals are generated as byproduct. Excessive oxygen free radicals cause cell death and reduce the rate of tissue regeneration and h...
Burns Biocompatible Materials Polyethylene Glycols Wound Healing Animals Lignin Micelles Disease Models, Animal Male Nanogels Mice, Inbred BALB C Hydrogels Mice Rheology Particle Size Antioxidants Skin
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Myricitrin inhibits vascular endothelial growth factor-induced angiogenesis of human umbilical vein endothelial cells and mice.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie Sep 17, 2020
In the present study, the protective effects of myricitrin against vascular endothelial growth factor (VEGF)-induced angiogenesis of vascular endothelial cells were characterized. Cells were induced with 50 ng/mL VEGF in the presence or absence of va...
Angiogenesis Inhibitors Vascular Endothelial Growth Factors Disease Models, Animal Humans Biomarkers Xenograft Model Antitumor Assays Apoptosis Animals Caspases Flavonoids Cell Line, Tumor Matrix Metalloproteinases Human Umbilical Vein Endothelial Cells Mice Neovascularization, Pathologic Neovascularization, Physiologic
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Machine Learning Algorithms for Early Detection of Bone Metastases in an Experimental Rat Model.

Journal of visualized experiments : JoVE Aug 16, 2020
Machine learning (ML) algorithms permit the integration of different features into a model to perform classification or regression tasks with an accuracy exceeding its constituents. This protocol describes the development of an ML algorithm to predic...
Early Detection of Cancer Bone Neoplasms Positron Emission Tomography Computed Tomography Animals Image Processing, Computer-Assisted Humans Rats Neural Networks, Computer Magnetic Resonance Imaging Machine Learning Disease Models, Animal Female Sensitivity and Specificity
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Accurate detection of spontaneous seizures using a generalized linear model with external validation.

Epilepsia Aug 6, 2020
OBJECTIVE: Seizure detection is a major facet of electroencephalography (EEG) analysis in neurocritical care, epilepsy diagnosis and management, and the instantiation of novel therapies such as closed-loop stimulation or optogenetic control of seizur...
Linear Models Epilepsies, Partial Electrocorticography Kainic Acid Excitatory Amino Acid Agonists Area Under Curve Electroencephalography Seizures Signal Processing, Computer-Assisted Machine Learning Reproducibility of Results Animals ROC Curve Rats Disease Models, Animal
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5G ultra-remote robot-assisted laparoscopic surgery in China.

Surgical endoscopy Jul 22, 2020
BACKGROUND: 5G communication technology has been applied to several fields in telemedicine, but its effectiveness, safety, and stability in remote laparoscopic telesurgery have not been established. Here, we conducted four ultra-remote laparoscopic s...
Animals Swine China Treatment Outcome Blood Loss, Surgical Disease Models, Animal Robotics Laparoscopy Robotic Surgical Procedures Telemedicine Intraoperative Complications Hepatectomy Wireless Technology Cystectomy Cholecystectomy Nephrectomy
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Machine learning-based segmentation of ischemic penumbra by using diffusion tensor metrics in a rat model.

Journal of biomedical science Jul 15, 2020
BACKGROUND: Recent trials have shown promise in intra-arterial thrombectomy after the first 6-24 h of stroke onset. Quick and precise identification of the salvageable tissue is essential for successful stroke management. In this study, we examined t...
Animals Male ROC Curve Rats Rats, Sprague-Dawley Machine Learning Disease Models, Animal Algorithms Infarction, Middle Cerebral Artery Ischemia Diffusion Tensor Imaging
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Utilization of a Deep Learning Algorithm for Microscope-Based Fatty Vacuole Quantification in a Fatty Liver Model in Mice.

Toxicologic pathology Jun 8, 2020
Quantification of fatty vacuoles in the liver, with differentiation from lumina of liver blood vessels and bile ducts, is an example where the traditional semiquantitative pathology assessment can be enhanced with artificial intelligence (AI) algorit...
Liver Non-alcoholic Fatty Liver Disease Microscopy Image Interpretation, Computer-Assisted Artificial Intelligence Vacuoles Machine Learning Animals Algorithms Deep Learning Mice Disease Models, Animal
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