AIMC Topic: Endothelial Cells

Clear Filters Showing 31 to 39 of 39 articles

G-Protein-Coupled Receptor 35 Mediates Human Saphenous Vein Vascular Smooth Muscle Cell Migration and Endothelial Cell Proliferation.

Journal of vascular research Apr 12, 2016
Vascular smooth muscle cell (VSMC) migration and proliferation is central to neointima formation in vein graft failure following coronary artery bypass. However, there are currently no pharmacological interventions that prevent vein graft failure thr...
Actin Cytoskeleton Receptors, G-Protein-Coupled Aminosalicylic Acids rho-Associated Kinases Naphthols rhoA GTP-Binding Protein HEK293 Cells Hydrazones Signal Transduction Myocytes, Smooth Muscle Thiourea Cell Movement Endothelial Cells Muscle, Smooth, Vascular Dose-Response Relationship, Drug Thiazolidines Purinones Humans Saphenous Vein Time Factors Cell Proliferation
View on PubMed DOI

Hericium erinaceus Inhibits TNF-α-Induced Angiogenesis and ROS Generation through Suppression of MMP-9/NF-κB Signaling and Activation of Nrf2-Mediated Antioxidant Genes in Human EA.hy926 Endothelial Cells.

Oxidative medicine and cellular longevity Dec 28, 2015
Hericium erinaceus (HE) is an edible mushroom that has been shown to exhibit anticancer and anti-inflammatory activities. We investigated the antiangiogenic and antioxidant potentials of ethanol extracts of HE in human endothelial (EA.hy926) cells up...
Tumor Necrosis Factor-alpha Antioxidants Inflammation Reactive Oxygen Species NF-kappa B Basidiomycota Signal Transduction Endothelial Cells Angiogenesis Inhibitors NF-E2-Related Factor 2 Neovascularization, Pathologic Humans Angiogenesis Inducing Agents Heme Oxygenase-1 Anti-Inflammatory Agents Glutathione Matrix Metalloproteinase 9 Intercellular Adhesion Molecule-1
View on PubMed DOI

Endothelial metabolic zonation in the vascular network: a spatiotemporal blueprint for angiogenesis.

American journal of physiology. Heart and circulatory physiology Aug 1, 2025
Angiogenesis, a cornerstone of vascular development, tissue regeneration, and tumor progression, is critically orchestrated by the metabolic behavior of endothelial cells (EC). Recent discoveries have redefined EC not as metabolically uniform entitie...
Humans Neovascularization, Pathologic Neovascularization, Physiologic Endothelial Cells Animals Angiogenesis Neoplasms Energy Metabolism
View on PubMed DOI

SCIG: Machine learning uncovers cell identity genes in single cells by genetic sequence codes.

Nucleic acids research May 22, 2025
Deciphering cell identity genes is pivotal to understanding cell differentiation, development, and cell identity dysregulation involving diseases. Here, we introduce SCIG, a machine-learning method to uncover cell identity genes in single cells. In a...
Gene Expression Regulation Single-Cell Analysis Endothelial Cells Gene Regulatory Networks Epigenesis, Genetic Humans Transcription Factors Cell Differentiation Machine Learning
View on PubMed DOI

Application of an artificial intelligence for quantitative analysis of endothelial capillary beds in vitro.

Clinical hemorheology and microcirculation Jan 1, 2024
BACKGROUND: The use of endothelial cell cultures has become fundamental to study angiogenesis. Recent advances in artificial intelligences (AI) offer opportunities to develop automated assessment methods in medical research, analyzing larger datasets...
Coculture Techniques Endothelial Cells Capillaries Humans Artificial Intelligence Neovascularization, Physiologic
View on PubMed DOI

Calcific aortic valve disease: turning therapeutic discovery up a notch.

Nature reviews. Cardiology May 1, 2021
Machine Learning Gene Regulatory Networks Calcinosis Humans Nitriles Endothelial Cells Receptors, Estrogen Cardiovascular Agents Aortic Valve Stenosis Aortic Valve Thiazoles Induced Pluripotent Stem Cells Receptor, Notch1 ERRalpha Estrogen-Related Receptor
View on PubMed DOI

Detection of Disease-Specific Parent Cells Via Distinct Population of Nano-Vesicles by Machine Learning.

Current pharmaceutical design Jan 1, 2020
BACKGROUND: The diagnosis and prognosis of pathological conditions, such as age-related macular degeneration (AMD) and cancer still need improvement. AMD is primarily caused due to the dysfunction of retinal pigment epithelium (RPE), whereas endothel...
Macular Degeneration Endothelial Cells Machine Learning Support Vector Machine Humans Artificial Intelligence
View on PubMed DOI

Blood Brain Barrier Permeability Prediction Using Machine Learning Techniques: An Update.

Current pharmaceutical biotechnology Jan 1, 2019
Blood Brain Barrier (BBB) is the collection of vessels of blood with special properties of permeability that allow a limited range of drug and compounds to pass through it. The BBB plays a vital role in maintaining balance between intracellular and e...
Permeability Endothelial Cells Capillary Permeability Pharmaceutical Preparations Models, Biological Diffusion Blood-Brain Barrier Animals Drug Development Machine Learning Brain Humans
View on PubMed DOI

[Effect of glutaredoxin on oxidative stress of umbilical vein endothelial cell exposed to Porphyromonas gingivalis lipo- polysaccharide].

Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology Dec 1, 2015
OBJECTIVE: This study measures the glutaredoxin (Grx) gene and protein expression in umbilical vein endothelial cells upon exposure to Porphyromonas gingivalis (P. gingivalis) lipopolysaccharide (LPS). The involvement of the Akt-signaling pathway is ...
Umbilical Veins Glutaredoxins Oxidative Stress Porphyromonas gingivalis Humans Signal Transduction Proto-Oncogene Proteins c-akt Lipopolysaccharides Endothelial Cells Phosphorylation
View on PubMed DOI
Popular Topics
Recent Journals