AIMC Topic: Gene Expression Profiling
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Mesenchymal stem cell transplantation ameliorates inflammation in spinal cord injury by inhibiting lactylation-related genes.
Cytokine
Jul 1, 2025
BACKGROUND: The immune microenvironment significantly influences neural regeneration in spinal cord injury (SCI). Lactate activates central nervous system (CNS) glial cells, prompting the secretion of proinflammatory cytokines and triggering an infla...
Deciphering the Regulatory Networks of the Migrasome-Associated Cell Subpopulation in Heterotopic Ossification via Multi-Omics Analysis.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Jun 30, 2025
Heterotopic ossification (HO) is a pathological process where bone forms in extraskeletal tissues, often occurring as a complication of tissue repair following injury. This condition can lead to movement limitations, pain, and functional impairment. ...
Unveiling the systemic impact of airborne microplastics: Integrating breathomics and machine learning with dual-tissue transcriptomics.
Journal of hazardous materials
Jun 15, 2025
Airborne microplastics (MPs) pose significant respiratory and systemic health risks upon inhalation; however, current assessment methods remain inadequate. This study integrates breathomics and transcriptomics to establish a non-invasive approach for...
Development and experimental verification of a prognosis model for hypoxia- and lactate metabolism-associated genes in HNSCC.
Medicine
Jun 13, 2025
Hypoxia and lactate metabolism are both distinctive characteristics of cancerous cells. Head and neck squamous cell carcinoma (HNSCC) is one of the most prevalent forms of cancer. The objective of this study was to construct a prognostic model of gen...
Artificial intelligence approaches for tumor phenotype stratification from single-cell transcriptomic data.
eLife
Jun 13, 2025
Single-cell RNA-sequencing (scRNA-seq) coupled with robust computational analysis facilitates the characterization of phenotypic heterogeneity within tumors. Current scRNA-seq analysis pipelines are capable of identifying a myriad of malignant and no...
Novel Transcriptomic Signatures in Fibrostenotic Crohn's Disease: Dysregulated Pathways, Promising Biomarkers, and Putative Therapeutic Targets.
Inflammatory bowel diseases
Jun 13, 2025
BACKGROUND: Fibrosis is a common complication in Crohn's disease (CD), often leading to intestinal strictures. This study aims to explore the transcriptomic signature of fibrostenotic ileal CD for a comprehensive characterization of biological and ce...
Integrative PPI network and random forest analysis identifies KIF4A, TOP2A, and ASPM protein macromolecules as novel protein biomarkers in renal carcinoma pathogenesis.
International journal of biological macromolecules
Jun 1, 2025
The pathogenesis of kidney cancer is not fully understood, so there is an urgent need to identify new biomarkers to improve diagnosis and treatment. The study identified KIF4A, TOP2A and ASPM as novel protein biomarkers for renal cancer and explored ...
Computational Biology
Kinesins
Gene Expression Profiling
Gene Expression Regulation, Neoplastic
Poly-ADP-Ribose Binding Proteins
Cell Line, Tumor
Nerve Tissue Proteins
DNA Topoisomerases, Type II
Protein Interaction Maps
Humans
Kidney Neoplasms
Epithelial-Mesenchymal Transition
Prognosis
Carcinoma, Renal Cell
Random Forest
Biomarkers, Tumor
Cancer type and survival prediction based on transcriptomic feature map.
Computers in biology and medicine
Jun 1, 2025
This study achieved cancer type and survival time prediction by transforming transcriptomic features into feature maps and employing deep learning models. Using transcriptomic data from 27 cancer types and survival data from 10 types in the TCGA data...
Exploring the Latent Information in Spatial Transcriptomics Data via Multi-View Graph Convolutional Network Based on Implicit Contrastive Learning.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Jun 1, 2025
Latest developments in spatial transcriptomics enable thoroughly profiling of gene expression while preserving tissue microenvironment. Connecting gene expression with spatial arrangement is key for precise spatial domain identification, enhancing th...
Upregulation of immune genes in the proliferative phase endometrium enables classification into women with recurrent pregnancy loss versus controls.
Human reproduction (Oxford, England)
Jun 1, 2025
STUDY QUESTION: Does the transcriptome of preconceptional endometrium in the proliferative phase show a specific profile in women with recurrent pregnancy loss (RPL)?
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